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1028 related items for PubMed ID: 17353349

  • 1. Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry.
    Erve JC, Vashishtha SC, DeMaio W, Talaat RE.
    Drug Metab Dispos; 2007 Jun; 35(6):908-16. PubMed ID: 17353349
    [Abstract] [Full Text] [Related]

  • 2. In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.
    Lang D, Freudenberger C, Weinz C.
    Drug Metab Dispos; 2009 May; 37(5):1046-55. PubMed ID: 19196846
    [Abstract] [Full Text] [Related]

  • 3. In vitro metabolism of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rat, monkey, and human liver microsomes and freshly isolated hepatocytes.
    Uchiyama M, Koda H, Fischer T, Mueller J, Yamamura N, Oguchi M, Iwabuchi H, Okazaki O, Izumi T.
    Drug Metab Dispos; 2011 Jul; 39(7):1311-9. PubMed ID: 21511943
    [Abstract] [Full Text] [Related]

  • 4. Detection of glutathione conjugates derived from 4-ipomeanol metabolism in bile of rats by liquid chromatography-tandem mass spectrometry.
    Alvarez-Diez TM, Zheng J.
    Drug Metab Dispos; 2004 Dec; 32(12):1345-50. PubMed ID: 15328249
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  • 6. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
    Yan Z, Easterwood LM, Maher N, Torres R, Huebert N, Yost GS.
    Chem Res Toxicol; 2007 Jan; 20(1):140-8. PubMed ID: 17226936
    [Abstract] [Full Text] [Related]

  • 7. Identification of novel metabolic pathways of pioglitazone in hepatocytes: N-glucuronidation of thiazolidinedione ring and sequential ring-opening pathway.
    Uchiyama M, Fischer T, Mueller J, Oguchi M, Yamamura N, Koda H, Iwabuchi H, Izumi T.
    Drug Metab Dispos; 2010 Jun; 38(6):946-56. PubMed ID: 20185540
    [Abstract] [Full Text] [Related]

  • 8. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA.
    Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
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  • 10. Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.
    Tevell A, Lennernäs H, Jönsson M, Norlin M, Lennernäs B, Bondesson U, Hedeland M.
    Drug Metab Dispos; 2006 Jun; 34(6):984-92. PubMed ID: 16540588
    [Abstract] [Full Text] [Related]

  • 11. Biotransformation of the novel inotropic agent toborinone (OPC-18790) in rats and dogs. Evidence for the formation of novel glutathione and two cysteine conjugates.
    Kitani M, Miyamoto G, Nagasawa M, Yamada T, Matsubara J, Uchida M, Odomi M.
    Drug Metab Dispos; 1997 Jun; 25(6):663-74. PubMed ID: 9193867
    [Abstract] [Full Text] [Related]

  • 12. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.
    Yao HT, Wu YS, Chang YW, Hsieh HP, Chen WC, Lan SJ, Chen CT, Chao YS, Chang L, Sun HY, Yeh TK.
    Drug Metab Dispos; 2007 Jul; 35(7):1042-9. PubMed ID: 17403915
    [Abstract] [Full Text] [Related]

  • 13. Biotransformation of felodipine in liver microsomes from rat, dog, and man.
    Bäärnhielm C, Backman A, Hoffmann KJ, Weidolf L.
    Drug Metab Dispos; 1986 Jul; 14(5):613-8. PubMed ID: 2876870
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  • 15. Metabolism of prazosin in rat and characterization of metabolites in plasma, urine, faeces, brain and bile using liquid chromatography/mass spectrometry (LC/MS).
    Erve JC, Vashishtha SC, Ojewoye O, Adedoyin A, Espina R, Demaio W, Talaat RE.
    Xenobiotica; 2008 May; 38(5):540-58. PubMed ID: 18421626
    [Abstract] [Full Text] [Related]

  • 16. Comparison of genistein metabolism in rats and humans using liver microsomes and hepatocytes.
    Bursztyka J, Perdu E, Tulliez J, Debrauwer L, Delous G, Canlet C, De Sousa G, Rahmani R, Benfenati E, Cravedi JP.
    Food Chem Toxicol; 2008 Mar; 46(3):939-48. PubMed ID: 18063284
    [Abstract] [Full Text] [Related]

  • 17. A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.
    Kalgutkar AS, Driscoll J, Zhao SX, Walker GS, Shepard RM, Soglia JR, Atherton J, Yu L, Mutlib AE, Munchhof MJ, Reiter LA, Jones CS, Doty JL, Trevena KA, Shaffer CL, Ripp SL.
    Chem Res Toxicol; 2007 Dec; 20(12):1954-65. PubMed ID: 17935300
    [Abstract] [Full Text] [Related]

  • 18. Metabolic products and pathways of fluorotelomer alcohols in isolated rat hepatocytes.
    Martin JW, Mabury SA, O'Brien PJ.
    Chem Biol Interact; 2005 Aug 15; 155(3):165-80. PubMed ID: 16098497
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  • 19. In vitro studies on the metabolic activation of the furanopyridine L-754,394, a highly potent and selective mechanism-based inhibitor of cytochrome P450 3A4.
    Sahali-Sahly Y, Balani SK, Lin JH, Baillie TA.
    Chem Res Toxicol; 1996 Sep 15; 9(6):1007-12. PubMed ID: 8870989
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  • 20. Identification of multiple glutathione conjugates of 8-amino- 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate (nomifensine) in liver microsomes and hepatocyte preparations: evidence of the bioactivation of nomifensine.
    Yu J, Mathisen DE, Burdette D, Brown DG, Becker C, Aharony D.
    Drug Metab Dispos; 2010 Jan 15; 38(1):46-60. PubMed ID: 19812352
    [Abstract] [Full Text] [Related]

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