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Journal Abstract Search

95 related items for PubMed ID: 17402721

  • 1. Dihydropyridopyrazinones and dihydropteridinones as corticotropin-releasing factor-1 receptor antagonists: structure-activity relationships and computational modeling.
    Dzierba CD, Tebben AJ, Wilde RG, Takvorian AG, Rafalski M, Kasireddy-Polam P, Klaczkiewicz JD, Pechulis AD, Davis AL, Sweet MP, Woo AM, Yang Z, Ebeltoft SM, Molski TF, Zhang G, Zaczek RC, Trainor GL, Combs AP, Gilligan PJ.
    J Med Chem; 2007 May 03; 50(9):2269-72. PubMed ID: 17402721
    [Abstract] [Full Text] [Related]

  • 2. Rational design, synthesis, and structure-activity relationships of aryltriazoles as novel corticotropin-releasing factor-1 receptor antagonists.
    Lowe RF, Nelson J, Dang TN, Crowe PD, Pahuja A, McCarthy JR, Grigoriadis DE, Conlon P, Saunders J, Chen C, Szabo T, Chen TK, Bozigian H.
    J Med Chem; 2005 Mar 10; 48(5):1540-9. PubMed ID: 15743196
    [Abstract] [Full Text] [Related]

  • 3. Single amino acid residue determinants of non-peptide antagonist binding to the corticotropin-releasing factor1 (CRF1) receptor.
    Hoare SR, Brown BT, Santos MA, Malany S, Betz SF, Grigoriadis DE.
    Biochem Pharmacol; 2006 Jul 14; 72(2):244-55. PubMed ID: 16750175
    [Abstract] [Full Text] [Related]

  • 4. Synthesis, structure-activity relationships, and in vivo properties of 3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as corticotropin-releasing factor-1 receptor antagonists.
    Dzierba CD, Takvorian AG, Rafalski M, Kasireddy-Polam P, Wong H, Molski TF, Zhang G, Li YW, Lelas S, Peng Y, McElroy JF, Zaczek RC, Taub RA, Combs AP, Gilligan PJ, Trainor GL.
    J Med Chem; 2004 Nov 04; 47(23):5783-90. PubMed ID: 15509177
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and structure-activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists.
    Dzierba CD, Sielecki TM, Arvanitis AG, Galka A, Johnson TL, Takvorian AG, Rafalski M, Kasireddy-Polam P, Vig S, Dasgupta B, Zhang G, Molski TF, Wong H, Zaczek RC, Lodge NJ, Combs AP, Gilligan PJ, Trainor GL, Bronson JJ, Macor JE.
    Bioorg Med Chem Lett; 2012 Aug 01; 22(15):4986-9. PubMed ID: 22749422
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  • 8. Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines.
    Arvanitis AG, Gilligan PJ, Chorvat RJ, Cheeseman RS, Christos TE, Bakthavatchalam R, Beck JP, Cocuzza AJ, Hobbs FW, Wilde RG, Arnold C, Chidester D, Curry M, He L, Hollis A, Klaczkiewicz J, Krenitsky PJ, Rescinito JP, Scholfield E, Culp S, De Souza EB, Fitzgerald L, Grigoriadis D, Tam SW, Shen HL.
    J Med Chem; 1999 Mar 11; 42(5):805-18. PubMed ID: 10072679
    [Abstract] [Full Text] [Related]

  • 9. Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists.
    Gross RS, Guo Z, Dyck B, Coon T, Huang CQ, Lowe RF, Marinkovic D, Moorjani M, Nelson J, Zamani-Kord S, Grigoriadis DE, Hoare SR, Crowe PD, Bu JH, Haddach M, McCarthy J, Saunders J, Sullivan R, Chen T, Williams JP.
    J Med Chem; 2005 Sep 08; 48(18):5780-93. PubMed ID: 16134945
    [Abstract] [Full Text] [Related]

  • 10. 8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.
    Gilligan PJ, He L, Clarke T, Tivitmahaisoon P, Lelas S, Li YW, Heman K, Fitzgerald L, Miller K, Zhang G, Marshall A, Krause C, McElroy J, Ward K, Shen H, Wong H, Grossman S, Nemeth G, Zaczek R, Arneric SP, Hartig P, Robertson DW, Trainor G.
    J Med Chem; 2009 May 14; 52(9):3073-83. PubMed ID: 19361210
    [Abstract] [Full Text] [Related]

  • 11. Chronic stress-induced alterations in amygdala responsiveness and behavior--modulation by trait anxiety and corticotropin-releasing factor systems.
    Sandi C, Cordero MI, Ugolini A, Varea E, Caberlotto L, Large CH.
    Eur J Neurosci; 2008 Nov 14; 28(9):1836-48. PubMed ID: 18973598
    [Abstract] [Full Text] [Related]

  • 12. Dihydropyrrole[2,3-d]pyridine derivatives as novel corticotropin-releasing factor-1 antagonists: mapping of the receptor binding pocket by in silico docking studies.
    Di Fabio R, Arban R, Bernasconi G, Braggio S, Blaney FE, Capelli AM, Castiglioni E, Donati D, Fazzolari E, Ratti E, Feriani A, Contini S, Gentile G, Ghirlanda D, Sabbatini FM, Andreotti D, Spada S, Marchioro C, Worby A, St-Denis Y.
    J Med Chem; 2008 Nov 27; 51(22):7273-86. PubMed ID: 18975927
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonists.
    Gilligan PJ, Clarke T, He L, Lelas S, Li YW, Heman K, Fitzgerald L, Miller K, Zhang G, Marshall A, Krause C, McElroy JF, Ward K, Zeller K, Wong H, Bai S, Saye J, Grossman S, Zaczek R, Arneric SP, Hartig P, Robertson D, Trainor G.
    J Med Chem; 2009 May 14; 52(9):3084-92. PubMed ID: 19361209
    [Abstract] [Full Text] [Related]

  • 14. Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation.
    Cheng H, Zhou L, Zhu W, Wang A, Tang C, Chan O, Sherwin RS, McCrimmon RJ.
    Am J Physiol Endocrinol Metab; 2007 Sep 14; 293(3):E705-12. PubMed ID: 17578887
    [Abstract] [Full Text] [Related]

  • 15. N-phenylphenylglycines as novel corticotropin releasing factor receptor antagonists.
    Molteni V, Penzotti J, Wilson DM, Termin AP, Mao L, Crane CM, Hassman F, Wang T, Wong H, Miller KJ, Grossman S, Grootenhuis PD.
    J Med Chem; 2004 May 06; 47(10):2426-9. PubMed ID: 15115386
    [Abstract] [Full Text] [Related]

  • 16. Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists.
    Guo Z, Tellew JE, Gross RS, Dyck B, Grey J, Haddach M, Kiankarimi M, Lanier M, Li BF, Luo Z, McCarthy JR, Moorjani M, Saunders J, Sullivan R, Zhang X, Zamani-Kord S, Grigoriadis DE, Crowe PD, Chen TK, Williams JP.
    J Med Chem; 2005 Aug 11; 48(16):5104-7. PubMed ID: 16078829
    [Abstract] [Full Text] [Related]

  • 17. The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists.
    Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Chandrasekhar J, Horvath RF, Ge P, Kershaw MT, Krause JE, Kehne J, Hoffman D, Doller D, Hodgetts KJ.
    Bioorg Med Chem Lett; 2008 Feb 01; 18(3):891-6. PubMed ID: 18180159
    [Abstract] [Full Text] [Related]

  • 18. Design, synthesis, and biological evaluation of 1,2,3,7-tetrahydro-6h-purin-6-one and 3,7-dihydro-1h-purine-2,6-dione derivatives as corticotropin-releasing factor(1) receptor antagonists.
    Hartz RA, Nanda KK, Ingalls CL, Ahuja VT, Molski TF, Zhang G, Wong H, Peng Y, Kelley M, Lodge NJ, Zaczek R, Gilligan PJ, Trainor GL.
    J Med Chem; 2004 Sep 09; 47(19):4741-54. PubMed ID: 15341489
    [Abstract] [Full Text] [Related]

  • 19. Synthesis, structure-activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists.
    Han X, Michne JA, Pin SS, Burris KD, Balanda LA, Fung LK, Fiedler T, Browman KE, Taber MT, Zhang J, Dubowchik GM.
    Bioorg Med Chem Lett; 2005 Sep 01; 15(17):3870-3. PubMed ID: 15990298
    [Abstract] [Full Text] [Related]

  • 20. Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists.
    Hartz RA, Ahuja VT, Arvanitis AG, Rafalski M, Yue EW, Denhart DJ, Schmitz WD, Ditta JL, Deskus JA, Brenner AB, Hobbs FW, Payne J, Lelas S, Li YW, Molski TF, Mattson GK, Peng Y, Wong H, Grace JE, Lentz KA, Qian-Cutrone J, Zhuo X, Shu YZ, Lodge NJ, Zaczek R, Combs AP, Olson RE, Bronson JJ, Mattson RJ, Macor JE.
    J Med Chem; 2009 Jul 23; 52(14):4173-91. PubMed ID: 19552437
    [Abstract] [Full Text] [Related]

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