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Journal Abstract Search

1042 related items for PubMed ID: 17403915

  • 1. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.
    Yao HT, Wu YS, Chang YW, Hsieh HP, Chen WC, Lan SJ, Chen CT, Chao YS, Chang L, Sun HY, Yeh TK.
    Drug Metab Dispos; 2007 Jul; 35(7):1042-9. PubMed ID: 17403915
    [Abstract] [Full Text] [Related]

  • 2. In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes.
    Aprile S, Del Grosso E, Tron GC, Grosa G.
    Drug Metab Dispos; 2007 Dec; 35(12):2252-61. PubMed ID: 17890446
    [Abstract] [Full Text] [Related]

  • 3. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes.
    Yamazaki H, Guo Z, Persmark M, Mimura M, Inoue K, Guengerich FP, Shimada T.
    Mol Pharmacol; 1994 Sep; 46(3):568-77. PubMed ID: 7935340
    [Abstract] [Full Text] [Related]

  • 4. Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A.
    Niwa T, Shiraga T, Mitani Y, Terakawa M, Tokuma Y, Kagayama A.
    Drug Metab Dispos; 2000 Sep; 28(9):1128-34. PubMed ID: 10950860
    [Abstract] [Full Text] [Related]

  • 5. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites.
    Remmel RP, Crews BC, Kozak KR, Kalgutkar AS, Marnett LJ.
    Drug Metab Dispos; 2004 Jan; 32(1):113-22. PubMed ID: 14709628
    [Abstract] [Full Text] [Related]

  • 6. CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver.
    Dehal SS, Kupfer D.
    Cancer Res; 1997 Aug 15; 57(16):3402-6. PubMed ID: 9270005
    [Abstract] [Full Text] [Related]

  • 7. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA.
    Biopharm Drug Dispos; 2006 Nov 15; 27(8):371-86. PubMed ID: 16944451
    [Abstract] [Full Text] [Related]

  • 8. Influence of N-substitution of 7-methoxy-4-(aminomethyl)-coumarin on cytochrome P450 metabolism and selectivity.
    Venhorst J, Onderwater RC, Meerman JH, Commandeur JN, Vermeulen NP.
    Drug Metab Dispos; 2000 Dec 15; 28(12):1524-32. PubMed ID: 11095593
    [Abstract] [Full Text] [Related]

  • 9. Metabolism of sanguinarine in human and in rat: characterization of oxidative metabolites produced by human CYP1A1 and CYP1A2 and rat liver microsomes using liquid chromatography-tandem mass spectrometry.
    Deroussent A, Ré M, Hoellinger H, Cresteil T.
    J Pharm Biomed Anal; 2010 Jul 08; 52(3):391-7. PubMed ID: 19804952
    [Abstract] [Full Text] [Related]

  • 10. Biotransformation of a novel antimitotic agent, I-387, by mouse, rat, dog, monkey, and human liver microsomes and in vivo pharmacokinetics in mice.
    Ahn S, Kearbey JD, Li CM, Duke CB, Miller DD, Dalton JT.
    Drug Metab Dispos; 2011 Apr 08; 39(4):636-43. PubMed ID: 21233217
    [Abstract] [Full Text] [Related]

  • 11. Metabolism of the new anxiolytic agent, a pyrido[1,2-]benzimidazole (PBI) analog (RWJ-53050), in rat and human hepatic S9 fractions, and in dog; identification of cytochrome p450 isoforms mediated in the human microsomal metabolism.
    Wu WN, McKown LA, Reitz AB.
    Eur J Drug Metab Pharmacokinet; 2006 Apr 08; 31(4):277-83. PubMed ID: 17315539
    [Abstract] [Full Text] [Related]

  • 12. Species differences in the toxicity and cytochrome P450 IIIA-dependent metabolism of digitoxin.
    Eberhart DC, Gemzik B, Halvorson MR, Parkinson A.
    Mol Pharmacol; 1991 Nov 08; 40(5):859-67. PubMed ID: 1944247
    [Abstract] [Full Text] [Related]

  • 13. Metabolism of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) by human liver microsomes: characterization of metabolic pathways and of cytochrome P450 isoforms involved.
    Baek MS, Kim JY, Myung SW, Yim YH, Jeong JH, Kim DH.
    Drug Metab Dispos; 2001 Apr 08; 29(4 Pt 1):381-8. PubMed ID: 11259320
    [Abstract] [Full Text] [Related]

  • 14. Metabolism of 2-amino-alpha-carboline. A food-borne heterocyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2.
    Raza H, King RS, Squires RB, Guengerich FP, Miller DW, Freeman JP, Lang NP, Kadlubar FF.
    Drug Metab Dispos; 1996 Apr 08; 24(4):395-400. PubMed ID: 8801053
    [Abstract] [Full Text] [Related]

  • 15. Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
    Tang W, Stearns RA, Wang RW, Chiu SH, Baillie TA.
    Chem Res Toxicol; 1999 Feb 08; 12(2):192-9. PubMed ID: 10027798
    [Abstract] [Full Text] [Related]

  • 16. Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation.
    Kim KH, Isin EM, Yun CH, Kim DH, Guengerich FP.
    FEBS J; 2006 May 08; 273(10):2223-31. PubMed ID: 16649998
    [Abstract] [Full Text] [Related]

  • 17. Characterization of diuron N-demethylation by mammalian hepatic microsomes and cDNA-expressed human cytochrome P450 enzymes.
    Abass K, Reponen P, Turpeinen M, Jalonen J, Pelkonen O.
    Drug Metab Dispos; 2007 Sep 08; 35(9):1634-41. PubMed ID: 17576805
    [Abstract] [Full Text] [Related]

  • 18. The In vitro hepatic metabolism of quinine in mice, rats and dogs: comparison with human liver microsomes.
    Zhao XJ, Ishizaki T.
    J Pharmacol Exp Ther; 1997 Dec 08; 283(3):1168-76. PubMed ID: 9399990
    [Abstract] [Full Text] [Related]

  • 19. Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.
    Reilly CA, Ehlhardt WJ, Jackson DA, Kulanthaivel P, Mutlib AE, Espina RJ, Moody DE, Crouch DJ, Yost GS.
    Chem Res Toxicol; 2003 Mar 08; 16(3):336-49. PubMed ID: 12641434
    [Abstract] [Full Text] [Related]

  • 20. Biotransformation of sufentanil in liver microsomes of rats, dogs, and humans.
    Lavrijsen K, Van Houdt J, Van Dyck D, Hendrickx J, Lauwers W, Hurkmans R, Bockx M, Janssen C, Meuldermans W, Heykants J.
    Drug Metab Dispos; 1990 Mar 08; 18(5):704-10. PubMed ID: 1981724
    [Abstract] [Full Text] [Related]

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