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Journal Abstract Search

1039 related items for PubMed ID: 17433262

  • 1. Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes.
    Murayama N, Imai N, Nakane T, Shimizu M, Yamazaki H.
    Biochem Pharmacol; 2007 Jun 15; 73(12):2020-6. PubMed ID: 17433262
    [Abstract] [Full Text] [Related]

  • 2. Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes.
    Yamazaki H, Shimada T.
    Arch Biochem Biophys; 1997 Oct 01; 346(1):161-9. PubMed ID: 9328296
    [Abstract] [Full Text] [Related]

  • 3. Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole.
    Hyland R, Jones BC, Smith DA.
    Drug Metab Dispos; 2003 May 01; 31(5):540-7. PubMed ID: 12695341
    [Abstract] [Full Text] [Related]

  • 4. In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3.
    Yanni SB, Annaert PP, Augustijns P, Ibrahim JG, Benjamin DK, Thakker DR.
    Drug Metab Dispos; 2010 Jan 01; 38(1):25-31. PubMed ID: 19841059
    [Abstract] [Full Text] [Related]

  • 5. O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes.
    Liu ZQ, Zhu B, Tan YF, Tan ZR, Wang LS, Huang SL, Shu Y, Zhou HH.
    J Pharmacol Exp Ther; 2002 Jan 01; 300(1):105-11. PubMed ID: 11752104
    [Abstract] [Full Text] [Related]

  • 6. Potent cytochrome P450 2C19 genotype-related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir.
    Mikus G, Schöwel V, Drzewinska M, Rengelshausen J, Ding R, Riedel KD, Burhenne J, Weiss J, Thomsen T, Haefeli WE.
    Clin Pharmacol Ther; 2006 Aug 01; 80(2):126-35. PubMed ID: 16890574
    [Abstract] [Full Text] [Related]

  • 7. CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.
    Ramírez J, Innocenti F, Schuetz EG, Flockhart DA, Relling MV, Santucci R, Ratain MJ.
    Drug Metab Dispos; 2004 Sep 01; 32(9):930-6. PubMed ID: 15319333
    [Abstract] [Full Text] [Related]

  • 8. Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor.
    Tang C, Shou M, Mei Q, Rushmore TH, Rodrigues AD.
    J Pharmacol Exp Ther; 2000 May 01; 293(2):453-9. PubMed ID: 10773015
    [Abstract] [Full Text] [Related]

  • 9. Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples.
    Yamazaki H, Inoue K, Shaw PM, Checovich WJ, Guengerich FP, Shimada T.
    J Pharmacol Exp Ther; 1997 Nov 01; 283(2):434-42. PubMed ID: 9353355
    [Abstract] [Full Text] [Related]

  • 10. Prosubstrates of CYP3A4, the major human hepatic cytochrome P450: transformation into substrates by other P450 isoforms.
    Stresser DM, Kupfer D.
    Biochem Pharmacol; 1998 Jun 01; 55(11):1861-71. PubMed ID: 9714305
    [Abstract] [Full Text] [Related]

  • 11. Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes.
    Niwa T, Shiraga T, Takagi A.
    Biol Pharm Bull; 2005 Sep 01; 28(9):1805-8. PubMed ID: 16141567
    [Abstract] [Full Text] [Related]

  • 12. Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes.
    Karam WG, Goldstein JA, Lasker JM, Ghanayem BI.
    Drug Metab Dispos; 1996 Oct 01; 24(10):1081-7. PubMed ID: 8894508
    [Abstract] [Full Text] [Related]

  • 13. Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs.
    Mancy A, Antignac M, Minoletti C, Dijols S, Mouries V, Duong NT, Battioni P, Dansette PM, Mansuy D.
    Biochemistry; 1999 Oct 26; 38(43):14264-70. PubMed ID: 10572000
    [Abstract] [Full Text] [Related]

  • 14. Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations.
    Lasker JM, Wester MR, Aramsombatdee E, Raucy JL.
    Arch Biochem Biophys; 1998 May 01; 353(1):16-28. PubMed ID: 9578596
    [Abstract] [Full Text] [Related]

  • 15. In-vitro metabolism of glycyrrhetinic acid by human and rat liver microsomes and its interactions with six CYP substrates.
    Zhao K, Ding M, Cao H, Cao ZX.
    J Pharm Pharmacol; 2012 Oct 01; 64(10):1445-51. PubMed ID: 22943175
    [Abstract] [Full Text] [Related]

  • 16. Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes.
    Miyazawa M, Shindo M, Shimada T.
    Drug Metab Dispos; 2001 Feb 01; 29(2):200-5. PubMed ID: 11159812
    [Abstract] [Full Text] [Related]

  • 17. Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism.
    Shon JH, Yoon YR, Kim MJ, Kim KA, Lim YC, Liu KH, Shin DH, Lee CH, Cha IJ, Shin JG.
    Br J Clin Pharmacol; 2005 May 01; 59(5):552-63. PubMed ID: 15842554
    [Abstract] [Full Text] [Related]

  • 18. In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19.
    Giraud C, Tran A, Rey E, Vincent J, Tréluyer JM, Pons G.
    Drug Metab Dispos; 2004 Nov 01; 32(11):1279-86. PubMed ID: 15483195
    [Abstract] [Full Text] [Related]

  • 19. Identification of cytochromes P450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro.
    Ufer M, Svensson JO, Krausz KW, Gelboin HV, Rane A, Tybring G.
    Eur J Clin Pharmacol; 2004 May 01; 60(3):173-82. PubMed ID: 15054565
    [Abstract] [Full Text] [Related]

  • 20. Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation.
    Butler AM, Murray M.
    J Pharmacol Exp Ther; 1997 Feb 01; 280(2):966-73. PubMed ID: 9023313
    [Abstract] [Full Text] [Related]

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