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283 related items for PubMed ID: 17438137

  • 1. MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy.
    Hoar K, Chakravarty A, Rabino C, Wysong D, Bowman D, Roy N, Ecsedy JA.
    Mol Cell Biol; 2007 Jun; 27(12):4513-25. PubMed ID: 17438137
    [Abstract] [Full Text] [Related]

  • 2. Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity.
    LeRoy PJ, Hunter JJ, Hoar KM, Burke KE, Shinde V, Ruan J, Bowman D, Galvin K, Ecsedy JA.
    Cancer Res; 2007 Jun 01; 67(11):5362-70. PubMed ID: 17545617
    [Abstract] [Full Text] [Related]

  • 3. MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.
    Huck JJ, Zhang M, McDonald A, Bowman D, Hoar KM, Stringer B, Ecsedy J, Manfredi MG, Hyer ML.
    Mol Cancer Res; 2010 Mar 01; 8(3):373-84. PubMed ID: 20197380
    [Abstract] [Full Text] [Related]

  • 4. Phase I assessment of new mechanism-based pharmacodynamic biomarkers for MLN8054, a small-molecule inhibitor of Aurora A kinase.
    Chakravarty A, Shinde V, Tabernero J, Cervantes A, Cohen RB, Dees EC, Burris H, Infante JR, Macarulla T, Elez E, Andreu J, Rodriguez-Braun E, Rosello S, von Mehren M, Meropol NJ, Langer CJ, ONeil B, Bowman D, Zhang M, Danaee H, Faron-Yowe L, Gray G, Liu H, Pappas J, Silverman L, Simpson C, Stringer B, Tirrell S, Veiby OP, Venkatakrishnan K, Galvin K, Manfredi M, Ecsedy JA.
    Cancer Res; 2011 Feb 01; 71(3):675-85. PubMed ID: 21148750
    [Abstract] [Full Text] [Related]

  • 5. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores.
    Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, Mortlock A, Keen N, Taylor SS.
    J Cell Biol; 2003 Apr 28; 161(2):267-80. PubMed ID: 12719470
    [Abstract] [Full Text] [Related]

  • 6. Trivalent dimethylarsenic compound induces histone H3 phosphorylation and abnormal localization of Aurora B kinase in HepG2 cells.
    Suzuki T, Miyazaki K, Kita K, Ochi T.
    Toxicol Appl Pharmacol; 2009 Dec 15; 241(3):275-82. PubMed ID: 19716834
    [Abstract] [Full Text] [Related]

  • 7. Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase.
    Manfredi MG, Ecsedy JA, Meetze KA, Balani SK, Burenkova O, Chen W, Galvin KM, Hoar KM, Huck JJ, LeRoy PJ, Ray ET, Sells TB, Stringer B, Stroud SG, Vos TJ, Weatherhead GS, Wysong DR, Zhang M, Bolen JB, Claiborne CF.
    Proc Natl Acad Sci U S A; 2007 Mar 06; 104(10):4106-11. PubMed ID: 17360485
    [Abstract] [Full Text] [Related]

  • 8. ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis.
    Venoux M, Basbous J, Berthenet C, Prigent C, Fernandez A, Lamb NJ, Rouquier S.
    Hum Mol Genet; 2008 Jan 15; 17(2):215-24. PubMed ID: 17925329
    [Abstract] [Full Text] [Related]

  • 9. Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole discovered by cellular screening efficiently kills cancer cells.
    Stolz A, Vogel C, Schneider V, Ertych N, Kienitz A, Yu H, Bastians H.
    Cancer Res; 2009 May 01; 69(9):3874-83. PubMed ID: 19366805
    [Abstract] [Full Text] [Related]

  • 10. 2-methoxyestradiol induces spindle aberrations, chromosome congression failure, and nondisjunction in mouse oocytes.
    Eichenlaub-Ritter U, Winterscheidt U, Vogt E, Shen Y, Tinneberg HR, Sorensen R.
    Biol Reprod; 2007 May 01; 76(5):784-93. PubMed ID: 17229934
    [Abstract] [Full Text] [Related]

  • 11. A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells.
    Fielding AB, Lim S, Montgomery K, Dobreva I, Dedhar S.
    Oncogene; 2011 Feb 03; 30(5):521-34. PubMed ID: 20838383
    [Abstract] [Full Text] [Related]

  • 12. The inhibition of Aurora A abrogates the mitotic delay induced by microtubule perturbing agents.
    Wysong DR, Chakravarty A, Hoar K, Ecsedy JA.
    Cell Cycle; 2009 Mar 15; 8(6):876-88. PubMed ID: 19221504
    [Abstract] [Full Text] [Related]

  • 13. Okadaic acid: chromosomal non-disjunction analysis in human lymphocytes and study of aneugenic pathway in CHO-K1 cells.
    Hégarat LL, Orsière T, Botta A, Fessard V.
    Mutat Res; 2005 Oct 15; 578(1-2):53-63. PubMed ID: 15885711
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  • 15. Targeted disruption of Aurora A causes abnormal mitotic spindle assembly, chromosome misalignment and embryonic lethality.
    Sasai K, Parant JM, Brandt ME, Carter J, Adams HP, Stass SA, Killary AM, Katayama H, Sen S.
    Oncogene; 2008 Jul 03; 27(29):4122-7. PubMed ID: 18345035
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  • 20. Determinants for the efficiency of anticancer drugs targeting either Aurora-A or Aurora-B kinases in human colon carcinoma cells.
    Kaestner P, Stolz A, Bastians H.
    Mol Cancer Ther; 2009 Jul 03; 8(7):2046-56. PubMed ID: 19584233
    [Abstract] [Full Text] [Related]

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