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124 related items for PubMed ID: 17446177

  • 1. Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design.
    Morgunova E, Saller S, Haase I, Cushman M, Bacher A, Fischer M, Ladenstein R.
    J Biol Chem; 2007 Jun 08; 282(23):17231-41. PubMed ID: 17446177
    [Abstract] [Full Text] [Related]

  • 2. Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors.
    Morgunova E, Meining W, Illarionov B, Haase I, Jin G, Bacher A, Cushman M, Fischer M, Ladenstein R.
    Biochemistry; 2005 Mar 01; 44(8):2746-58. PubMed ID: 15723519
    [Abstract] [Full Text] [Related]

  • 3. Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase from Bacillus anthracis.
    Morgunova E, Illarionov B, Saller S, Popov A, Sambaiah T, Bacher A, Cushman M, Fischer M, Ladenstein R.
    Acta Crystallogr D Biol Crystallogr; 2010 Sep 01; 66(Pt 9):1001-11. PubMed ID: 20823551
    [Abstract] [Full Text] [Related]

  • 4. Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata.
    Shankar M, Wilbanks SM, Nakatani Y, Monk BC, Tyndall JD.
    Acta Crystallogr D Biol Crystallogr; 2013 Aug 01; 69(Pt 8):1580-6. PubMed ID: 23897480
    [Abstract] [Full Text] [Related]

  • 5. Studies on the lumazine synthase/riboflavin synthase complex of Bacillus subtilis: crystal structure analysis of reconstituted, icosahedral beta-subunit capsids with bound substrate analogue inhibitor at 2.4 A resolution.
    Ritsert K, Huber R, Turk D, Ladenstein R, Schmidt-Bäse K, Bacher A.
    J Mol Biol; 1995 Oct 13; 253(1):151-67. PubMed ID: 7473709
    [Abstract] [Full Text] [Related]

  • 6. Crystal structure analysis of a pentameric fungal and an icosahedral plant lumazine synthase reveals the structural basis for differences in assembly.
    Persson K, Schneider G, Jordan DB, Viitanen PV, Sandalova T.
    Protein Sci; 1999 Nov 13; 8(11):2355-65. PubMed ID: 10595538
    [Abstract] [Full Text] [Related]

  • 7. Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase.
    Cushman M, Yang D, Mihalic JT, Chen J, Gerhardt S, Huber R, Fischer M, Kis K, Bacher A.
    J Org Chem; 2002 Oct 04; 67(20):6871-7. PubMed ID: 12353976
    [Abstract] [Full Text] [Related]

  • 8. Design, synthesis, and evaluation of acyclic C-nucleoside and N-methylated derivatives of the ribitylaminopyrimidine substrate of lumazine synthase as potential enzyme inhibitors and mechanistic probes.
    Chen J, Sambaiah T, Illarionov B, Fischer M, Bacher A, Cushman M.
    J Org Chem; 2004 Oct 15; 69(21):6996-7003. PubMed ID: 15471444
    [Abstract] [Full Text] [Related]

  • 9. A new series of 3-alkyl phosphate derivatives of 4,5,6,7-tetrahydro-1-D-ribityl-1H-pyrazolo[3,4-d]pyrimidinedione as inhibitors of lumazine synthase: design, synthesis, and evaluation.
    Zhang Y, Jin G, Illarionov B, Bacher A, Fischer M, Cushman M.
    J Org Chem; 2007 Sep 14; 72(19):7176-84. PubMed ID: 17705537
    [Abstract] [Full Text] [Related]

  • 10. Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis.
    Morgunova E, Illarionov B, Sambaiah T, Haase I, Bacher A, Cushman M, Fischer M, Ladenstein R.
    FEBS J; 2006 Oct 14; 273(20):4790-804. PubMed ID: 16984393
    [Abstract] [Full Text] [Related]

  • 11. Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans.
    Echt S, Bauer S, Steinbacher S, Huber R, Bacher A, Fischer M.
    J Mol Biol; 2004 Aug 20; 341(4):1085-96. PubMed ID: 15328619
    [Abstract] [Full Text] [Related]

  • 12. X-ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 A resolution: determinants of thermostability revealed from structural comparisons.
    Zhang X, Meining W, Fischer M, Bacher A, Ladenstein R.
    J Mol Biol; 2001 Mar 09; 306(5):1099-114. PubMed ID: 11237620
    [Abstract] [Full Text] [Related]

  • 13. Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of tiboflavin synthase and lumazine synthase.
    Cushman M, Sambaiah T, Jin G, Illarionov B, Fischer M, Bacher A.
    J Org Chem; 2004 Feb 06; 69(3):601-12. PubMed ID: 14750781
    [Abstract] [Full Text] [Related]

  • 14. The crystal structure of a major secreted aspartic proteinase from Candida albicans in complexes with two inhibitors.
    Cutfield SM, Dodson EJ, Anderson BF, Moody PC, Marshall CJ, Sullivan PA, Cutfield JF.
    Structure; 1995 Nov 15; 3(11):1261-71. PubMed ID: 8591036
    [Abstract] [Full Text] [Related]

  • 15. Divergence in macromolecular assembly: X-ray crystallographic structure analysis of lumazine synthase from Brucella abortus.
    Braden BC, Velikovsky CA, Cauerhff AA, Polikarpov I, Goldbaum FA.
    J Mol Biol; 2000 Apr 14; 297(5):1031-6. PubMed ID: 10764570
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase.
    Talukdar A, Illarionov B, Bacher A, Fischer M, Cushman M.
    J Org Chem; 2007 Sep 14; 72(19):7167-75. PubMed ID: 17696548
    [Abstract] [Full Text] [Related]

  • 17. Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase.
    Cushman M, Yang D, Gerhardt S, Huber R, Fischer M, Kis K, Bacher A.
    J Org Chem; 2002 Aug 09; 67(16):5807-16. PubMed ID: 12153285
    [Abstract] [Full Text] [Related]

  • 18. Crystal structure analysis of icosahedral lumazine synthase from Salmonella typhimurium, an antibacterial drug target.
    Kumar P, Singh M, Karthikeyan S.
    Acta Crystallogr D Biol Crystallogr; 2011 Feb 09; 67(Pt 2):131-9. PubMed ID: 21245535
    [Abstract] [Full Text] [Related]

  • 19. A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus.
    Zhang X, Meining W, Cushman M, Haase I, Fischer M, Bacher A, Ladenstein R.
    J Mol Biol; 2003 Apr 18; 328(1):167-82. PubMed ID: 12684006
    [Abstract] [Full Text] [Related]

  • 20. Insights into the selective inhibition of Candida albicans secreted aspartyl protease: a docking analysis study.
    Pranav Kumar SK, Kulkarni VM.
    Bioorg Med Chem; 2002 Apr 18; 10(4):1153-70. PubMed ID: 11836127
    [Abstract] [Full Text] [Related]

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