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106 related items for PubMed ID: 17466275

  • 1. Biogenesis and processing of the amyloid precursor protein in the early secretory pathway.
    Selivanova A, Winblad B, Dantuma NP, Farmery MR.
    Biochem Biophys Res Commun; 2007 Jun 15; 357(4):1034-9. PubMed ID: 17466275
    [Abstract] [Full Text] [Related]

  • 2. COPI-mediated retrograde transport is required for efficient gamma-secretase cleavage of the amyloid precursor protein.
    Selivanova A, Winblad B, Farmery MR, Dantuma NP, Ankarcrona M.
    Biochem Biophys Res Commun; 2006 Nov 10; 350(1):220-6. PubMed ID: 16999935
    [Abstract] [Full Text] [Related]

  • 3. Novel alpha-secretase cleavage of Alzheimer's amyloid beta precursor protein in the endoplasmic reticulum of COS7 cells.
    Shin RW, Saido TC, Maeda M, Kitamoto T.
    Neurosci Lett; 2005 Mar 07; 376(1):14-9. PubMed ID: 15694266
    [Abstract] [Full Text] [Related]

  • 4. Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface.
    Kaether C, Schmitt S, Willem M, Haass C.
    Traffic; 2006 Apr 07; 7(4):408-15. PubMed ID: 16536739
    [Abstract] [Full Text] [Related]

  • 5. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
    Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.
    Neurobiol Dis; 2007 Feb 07; 25(2):291-6. PubMed ID: 17071095
    [Abstract] [Full Text] [Related]

  • 6. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
    Esposito L, Gan L, Yu GQ, Essrich C, Mucke L.
    J Neurochem; 2004 Dec 07; 91(6):1260-74. PubMed ID: 15584903
    [Abstract] [Full Text] [Related]

  • 7. The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
    Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, Saftig P, De Strooper B, Annaert W.
    J Cell Biol; 2001 Aug 20; 154(4):731-40. PubMed ID: 11502763
    [Abstract] [Full Text] [Related]

  • 8. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.
    Réchards M, Xia W, Oorschot V, van Dijk S, Annaert W, Selkoe DJ, Klumperman J.
    Traffic; 2006 Mar 20; 7(3):354-64. PubMed ID: 16497228
    [Abstract] [Full Text] [Related]

  • 9. Dilysine retrieval signal-containing p24 proteins collaborate in inhibiting γ-cleavage of amyloid precursor protein.
    Hasegawa H, Liu L, Nishimura M.
    J Neurochem; 2010 Nov 20; 115(3):771-81. PubMed ID: 20807314
    [Abstract] [Full Text] [Related]

  • 10. Rac1 changes the substrate specificity of gamma-secretase between amyloid precursor protein and Notch1.
    Boo JH, Sohn JH, Kim JE, Song H, Mook-Jung I.
    Biochem Biophys Res Commun; 2008 Aug 08; 372(4):913-7. PubMed ID: 18538664
    [Abstract] [Full Text] [Related]

  • 11. Amyloid precursor protein promotes endoplasmic reticulum stress-induced cell death via C/EBP homologous protein-mediated pathway.
    Takahashi K, Niidome T, Akaike A, Kihara T, Sugimoto H.
    J Neurochem; 2009 Jun 08; 109(5):1324-37. PubMed ID: 19476545
    [Abstract] [Full Text] [Related]

  • 12. Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.
    Harris B, Pereira I, Parkin E.
    Brain Res; 2009 Nov 03; 1296():203-15. PubMed ID: 19679113
    [Abstract] [Full Text] [Related]

  • 13. The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.
    Laudon H, Winblad B, Näslund J.
    Physiol Behav; 2007 Sep 10; 92(1-2):115-20. PubMed ID: 17588625
    [Abstract] [Full Text] [Related]

  • 14. Intracellular pathways of folded and misfolded amyloid precursor protein degradation.
    Hare JF.
    Arch Biochem Biophys; 2006 Jul 01; 451(1):79-90. PubMed ID: 16764819
    [Abstract] [Full Text] [Related]

  • 15. Effects of sulindac sulfide on the membrane architecture and the activity of gamma-secretase.
    Gamerdinger M, Clement AB, Behl C.
    Neuropharmacology; 2008 May 01; 54(6):998-1005. PubMed ID: 18359496
    [Abstract] [Full Text] [Related]

  • 16. The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.
    Lichtenthaler SF, Beher D, Grimm HS, Wang R, Shearman MS, Masters CL, Beyreuther K.
    Proc Natl Acad Sci U S A; 2002 Feb 05; 99(3):1365-70. PubMed ID: 11805291
    [Abstract] [Full Text] [Related]

  • 17. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.
    J Pharmacol Exp Ther; 2009 Nov 05; 331(2):598-608. PubMed ID: 19671883
    [Abstract] [Full Text] [Related]

  • 18. Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms.
    Cater MA, McInnes KT, Li QX, Volitakis I, La Fontaine S, Mercer JF, Bush AI.
    Biochem J; 2008 May 15; 412(1):141-52. PubMed ID: 18248325
    [Abstract] [Full Text] [Related]

  • 19. New protein kinase C activator regulates amyloid precursor protein processing in vitro by increasing alpha-secretase activity.
    Yang HQ, Pan J, Ba MW, Sun ZK, Ma GZ, Lu GQ, Xiao Q, Chen SD.
    Eur J Neurosci; 2007 Jul 15; 26(2):381-91. PubMed ID: 17650113
    [Abstract] [Full Text] [Related]

  • 20. LRP1 modulates APP trafficking along early compartments of the secretory pathway.
    Waldron E, Heilig C, Schweitzer A, Nadella N, Jaeger S, Martin AM, Weggen S, Brix K, Pietrzik CU.
    Neurobiol Dis; 2008 Aug 15; 31(2):188-97. PubMed ID: 18559293
    [Abstract] [Full Text] [Related]

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