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Journal Abstract Search

445 related items for PubMed ID: 17468177

  • 1. Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects.
    Pacheco CD, Kunkel R, Lieberman AP.
    Hum Mol Genet; 2007 Jun 15; 16(12):1495-503. PubMed ID: 17468177
    [Abstract] [Full Text] [Related]

  • 2. Lipid trafficking defects increase Beclin-1 and activate autophagy in Niemann-Pick type C disease.
    Pacheco CD, Lieberman AP.
    Autophagy; 2007 Jun 15; 3(5):487-9. PubMed ID: 17611388
    [Abstract] [Full Text] [Related]

  • 3. FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.
    Newton J, Hait NC, Maceyka M, Colaco A, Maczis M, Wassif CA, Cougnoux A, Porter FD, Milstien S, Platt N, Platt FM, Spiegel S.
    FASEB J; 2017 Apr 15; 31(4):1719-1730. PubMed ID: 28082351
    [Abstract] [Full Text] [Related]

  • 4. The autophagic defect in Niemann-Pick disease type C neurons differs from somatic cells and reduces neuronal viability.
    Meske V, Erz J, Priesnitz T, Ohm TG.
    Neurobiol Dis; 2014 Apr 15; 64():88-97. PubMed ID: 24412309
    [Abstract] [Full Text] [Related]

  • 5. Niemann-Pick C variant detection by altered sphingolipid trafficking and correlation with mutations within a specific domain of NPC1.
    Sun X, Marks DL, Park WD, Wheatley CL, Puri V, O'Brien JF, Kraft DL, Lundquist PA, Patterson MC, Pagano RE, Snow K.
    Am J Hum Genet; 2001 Jun 15; 68(6):1361-72. PubMed ID: 11349231
    [Abstract] [Full Text] [Related]

  • 6. Targeting defective sphingosine kinase 1 in Niemann-Pick type C disease with an activator mitigates cholesterol accumulation.
    Newton J, Palladino END, Weigel C, Maceyka M, Gräler MH, Senkal CE, Enriz RD, Marvanova P, Jampilek J, Lima S, Milstien S, Spiegel S.
    J Biol Chem; 2020 Jul 03; 295(27):9121-9133. PubMed ID: 32385114
    [Abstract] [Full Text] [Related]

  • 7. Different Trafficking Phenotypes of Niemann-Pick C1 Gene Mutations Correlate with Various Alterations in Lipid Storage, Membrane Composition and Miglustat Amenability.
    Brogden G, Shammas H, Walters F, Maalouf K, Das AM, Naim HY, Rizk S.
    Int J Mol Sci; 2020 Mar 19; 21(6):. PubMed ID: 32204338
    [Abstract] [Full Text] [Related]

  • 8. The pathogenesis of Niemann-Pick type C disease: a role for autophagy?
    Pacheco CD, Lieberman AP.
    Expert Rev Mol Med; 2008 Sep 10; 10():e26. PubMed ID: 18782459
    [Abstract] [Full Text] [Related]

  • 9. Mechanisms and consequences of impaired lipid trafficking in Niemann-Pick type C1-deficient mammalian cells.
    Karten B, Peake KB, Vance JE.
    Biochim Biophys Acta; 2009 Jul 10; 1791(7):659-70. PubMed ID: 19416638
    [Abstract] [Full Text] [Related]

  • 10. ORMDL mislocalization by impaired autophagy in Niemann-Pick type C disease leads to increased de novo sphingolipid biosynthesis.
    Brown RDR, Mahawar U, Wattenberg BW, Spiegel S.
    J Lipid Res; 2024 Jun 10; 65(6):100556. PubMed ID: 38719150
    [Abstract] [Full Text] [Related]

  • 11. Cholesterol accumulation is associated with lysosomal dysfunction and autophagic stress in Npc1 -/- mouse brain.
    Liao G, Yao Y, Liu J, Yu Z, Cheung S, Xie A, Liang X, Bi X.
    Am J Pathol; 2007 Sep 10; 171(3):962-75. PubMed ID: 17631520
    [Abstract] [Full Text] [Related]

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  • 13. β-Cyclodextrin-threaded biocleavable polyrotaxanes ameliorate impaired autophagic flux in Niemann-Pick type C disease.
    Tamura A, Yui N.
    J Biol Chem; 2015 Apr 10; 290(15):9442-54. PubMed ID: 25713067
    [Abstract] [Full Text] [Related]

  • 14. Niemann-Pick type C mutations cause lipid traffic jam.
    Liscum L.
    Traffic; 2000 Mar 10; 1(3):218-25. PubMed ID: 11208105
    [Abstract] [Full Text] [Related]

  • 15. Adenovirus RIDα uncovers a novel pathway requiring ORP1L for lipid droplet formation independent of NPC1.
    Cianciola NL, Greene DJ, Morton RE, Carlin CR.
    Mol Biol Cell; 2013 Nov 10; 24(21):3309-25. PubMed ID: 24025716
    [Abstract] [Full Text] [Related]

  • 16. Trafficking defects in endogenously synthesized cholesterol in fibroblasts, macrophages, hepatocytes, and glial cells from Niemann-Pick type C1 mice.
    Reid PC, Sugii S, Chang TY.
    J Lipid Res; 2003 May 10; 44(5):1010-9. PubMed ID: 12611909
    [Abstract] [Full Text] [Related]

  • 17. Protein transduction of Rab9 in Niemann-Pick C cells reduces cholesterol storage.
    Narita K, Choudhury A, Dobrenis K, Sharma DK, Holicky EL, Marks DL, Walkley SU, Pagano RE.
    FASEB J; 2005 Sep 10; 19(11):1558-60. PubMed ID: 15972801
    [Abstract] [Full Text] [Related]

  • 18. NPC1 plays a role in the trafficking of specific cargo to melanosomes.
    Rus AA, Militaru IV, Popa I, Munteanu CVA, Sima LE, Platt N, Platt FM, Petrescu ȘM.
    J Biol Chem; 2023 Aug 10; 299(8):105024. PubMed ID: 37423302
    [Abstract] [Full Text] [Related]

  • 19. Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis.
    Pacheco CD, Elrick MJ, Lieberman AP.
    Hum Mol Genet; 2009 Mar 01; 18(5):956-65. PubMed ID: 19074461
    [Abstract] [Full Text] [Related]

  • 20. Adenovirus expressing an NPC1-GFP fusion gene corrects neuronal and nonneuronal defects associated with Niemann pick type C disease.
    Paul CA, Reid PC, Boegle AK, Karten B, Zhang M, Jiang ZG, Franz D, Lin L, Chang TY, Vance JE, Blanchette-Mackie J, Maue RA.
    J Neurosci Res; 2005 Sep 01; 81(5):706-19. PubMed ID: 16015597
    [Abstract] [Full Text] [Related]

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