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Journal Abstract Search

687 related items for PubMed ID: 17475221

  • 1. Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways.
    Chen YC, Lu PH, Pan SL, Teng CM, Kuo SC, Lin TP, Ho YF, Huang YC, Guh JH.
    Biochem Pharmacol; 2007 Jun 30; 74(1):10-9. PubMed ID: 17475221
    [Abstract] [Full Text] [Related]

  • 2. Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery.
    Lu PH, Kung FL, Kuo SC, Chueh SC, Guh JH.
    Naunyn Schmiedebergs Arch Pharmacol; 2006 Dec 30; 374(3):223-33. PubMed ID: 17102938
    [Abstract] [Full Text] [Related]

  • 3. WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers.
    Hsiao CJ, Li TK, Chan YL, Hsin LW, Liao CH, Lee CH, Lyu PC, Guh JH.
    Biochem Pharmacol; 2008 Feb 15; 75(4):847-56. PubMed ID: 18035333
    [Abstract] [Full Text] [Related]

  • 4. Induction of mitotic arrest and apoptosis by a novel synthetic quinolone analogue, CWC-8, via intrinsic and extrinsic apoptotic pathways in human osteogenic sarcoma U-2 OS cells.
    Chang YH, Yang JS, Kuo SC, Chung JG.
    Anticancer Res; 2009 Aug 15; 29(8):3139-48. PubMed ID: 19661327
    [Abstract] [Full Text] [Related]

  • 5. Genistein inversely affects tubulin-binding agent-induced apoptosis in human breast cancer cells.
    Liao CH, Pan SL, Guh JH, Teng CM.
    Biochem Pharmacol; 2004 Jun 01; 67(11):2031-8. PubMed ID: 15135300
    [Abstract] [Full Text] [Related]

  • 6. BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo.
    Kuo CC, Hsieh HP, Pan WY, Chen CP, Liou JP, Lee SJ, Chang YL, Chen LT, Chen CT, Chang JY.
    Cancer Res; 2004 Jul 01; 64(13):4621-8. PubMed ID: 15231674
    [Abstract] [Full Text] [Related]

  • 7. MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells.
    Yang JS, Hour MJ, Huang WW, Lin KL, Kuo SC, Chung JG.
    J Pharmacol Exp Ther; 2010 Aug 01; 334(2):477-88. PubMed ID: 20463006
    [Abstract] [Full Text] [Related]

  • 8. The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells.
    Huang SM, Yang JS, Tsai SC, Chen MH, Hsu MH, Lin HY, Chou LC, Chinag JH, Lee KH, Huang LJ, Kuo SC.
    Int J Oncol; 2011 May 01; 38(5):1357-64. PubMed ID: 21344160
    [Abstract] [Full Text] [Related]

  • 9. 2-(Naphthalene-1-yl)-6-pyrrolidinyl-4-quinazolinone inhibits skin cancer M21 cell proliferation through aberrant expression of microtubules and the cell cycle.
    Wu YC, Hour MJ, Leung WC, Wu CY, Liu WZ, Chang YH, Lee HZ.
    J Pharmacol Exp Ther; 2011 Sep 01; 338(3):942-51. PubMed ID: 21652781
    [Abstract] [Full Text] [Related]

  • 10. Salvinal, a novel microtubule inhibitor isolated from Salvia miltiorrhizae Bunge (Danshen), with antimitotic activity in multidrug-sensitive and -resistant human tumor cells.
    Chang JY, Chang CY, Kuo CC, Chen LT, Wein YS, Kuo YH.
    Mol Pharmacol; 2004 Jan 01; 65(1):77-84. PubMed ID: 14722239
    [Abstract] [Full Text] [Related]

  • 11. [Induction of G2 /M phase arrest and apoptosis of MCF-7 cells by novel benzofuran lignan via suppressing cell cycle proteins].
    Yang H, Cai YC, Pang JY, Li YQ, Zeng ZL, Xu ZL, Xian LJ.
    Yao Xue Xue Bao; 2008 Feb 01; 43(2):138-44. PubMed ID: 18507339
    [Abstract] [Full Text] [Related]

  • 12. 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway.
    Hsu TS, Chen C, Lee PT, Chiu SJ, Liu HF, Tsai CC, Chao JI.
    Cancer Chemother Pharmacol; 2008 Oct 01; 62(5):799-808. PubMed ID: 18193228
    [Abstract] [Full Text] [Related]

  • 13. Double blockade of cell cycle at g(1)-s transition and m phase by 3-iodoacetamido benzoyl ethyl ester, a new type of tubulin ligand.
    Jiang JD, Denner L, Ling YH, Li JN, Davis A, Wang Y, Li Y, Roboz J, Wang LG, Perez-Soler R, Marcelli M, Bekesi G, Holland JF.
    Cancer Res; 2002 Nov 01; 62(21):6080-8. PubMed ID: 12414632
    [Abstract] [Full Text] [Related]

  • 14. Modulation of cell-cycle regulatory signaling network by 2-methoxyestradiol in prostate cancer cells is mediated through multiple signal transduction pathways.
    Ray G, Dhar G, Van Veldhuizen PJ, Banerjee S, Saxena NK, Sengupta K, Banerjee SK.
    Biochemistry; 2006 Mar 21; 45(11):3703-13. PubMed ID: 16533053
    [Abstract] [Full Text] [Related]

  • 15. A novel oral indoline-sulfonamide agent, N-[1-(4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-7-yl]-isonicotinamide (J30), exhibits potent activity against human cancer cells in vitro and in vivo through the disruption of microtubule.
    Liou JP, Hsu KS, Kuo CC, Chang CY, Chang JY.
    J Pharmacol Exp Ther; 2007 Oct 21; 323(1):398-405. PubMed ID: 17660383
    [Abstract] [Full Text] [Related]

  • 16. Carboxyamido-triazole inhibits proliferation of human breast cancer cells via G(2)/M cell cycle arrest and apoptosis.
    Guo L, Li ZS, Wang HL, Ye CY, Zhang DC.
    Eur J Pharmacol; 2006 May 24; 538(1-3):15-22. PubMed ID: 16696967
    [Abstract] [Full Text] [Related]

  • 17. Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway.
    Ho CH, Hsu JL, Liu SP, Hsu LC, Chang WL, Chao CC, Guh JH.
    Prostate; 2015 Sep 24; 75(13):1454-66. PubMed ID: 26180030
    [Abstract] [Full Text] [Related]

  • 18. [Asiaticoside inducing apoptosis of tumor cells and enhancing anti-tumor activity of vincristine].
    Huang YH, Zhang SH, Zhen RX, Xu XD, Zhen YS.
    Ai Zheng; 2004 Dec 24; 23(12):1599-604. PubMed ID: 15601545
    [Abstract] [Full Text] [Related]

  • 19. Novel quinolone CHM-1 induces apoptosis and inhibits metastasis in a human osterogenic sarcoma cell line.
    Hsu SC, Yang JS, Kuo CL, Lo C, Lin JP, Hsia TC, Lin JJ, Lai KC, Kuo HM, Huang LJ, Kuo SC, Wood WG, Chung JG.
    J Orthop Res; 2009 Dec 24; 27(12):1637-44. PubMed ID: 19557855
    [Abstract] [Full Text] [Related]

  • 20. beta-Sitosterol induces G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways.
    Moon DO, Kim MO, Choi YH, Kim GY.
    Cancer Lett; 2008 Jun 18; 264(2):181-91. PubMed ID: 18314257
    [Abstract] [Full Text] [Related]

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