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330 related items for PubMed ID: 17482584

  • 1. Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons.
    Yamashita K, Kotani Y, Nakajima Y, Shimazawa M, Yoshimura S, Nakashima S, Iwama T, Hara H.
    Brain Res; 2007 Jun 18; 1154():215-24. PubMed ID: 17482584
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.
    Rikitake Y, Kim HH, Huang Z, Seto M, Yano K, Asano T, Moskowitz MA, Liao JK.
    Stroke; 2005 Oct 18; 36(10):2251-7. PubMed ID: 16141422
    [Abstract] [Full Text] [Related]

  • 3. Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain.
    Wu J, Li J, Hu H, Liu P, Fang Y, Wu D.
    Cell Mol Neurobiol; 2012 Oct 18; 32(7):1187-97. PubMed ID: 22552888
    [Abstract] [Full Text] [Related]

  • 4. Inhibition of intracellular Ca2+ release by a Rho-kinase inhibitor for the treatment of ischemic damage in primary cultured rat hippocampal neurons.
    Huang L, Li Q, Li H, He Z, Cheng Z, Chen J, Guo L.
    Eur J Pharmacol; 2009 Jan 14; 602(2-3):238-44. PubMed ID: 19070614
    [Abstract] [Full Text] [Related]

  • 5. Fasudil hydrochloride protects neurons in rat hippocampal CA1 region through inhibiting GluR6-MLK3-JNKs signal pathway.
    Wei XE, Zhang FY, Wang K, Zhang QX, Rong LQ.
    Cell Biochem Biophys; 2014 Sep 14; 70(1):415-21. PubMed ID: 24793642
    [Abstract] [Full Text] [Related]

  • 6. Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice.
    Ding J, Li QY, Wang X, Sun CH, Lu CZ, Xiao BG.
    J Neurochem; 2010 Sep 14; 114(6):1619-29. PubMed ID: 20882700
    [Abstract] [Full Text] [Related]

  • 7. Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF.
    Ding J, Yu JZ, Li QY, Wang X, Lu CZ, Xiao BG.
    Brain Behav Immun; 2009 Nov 14; 23(8):1083-8. PubMed ID: 19447168
    [Abstract] [Full Text] [Related]

  • 8. Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.
    Satoh S, Toshima Y, Ikegaki I, Iwasaki M, Asano T.
    Brain Res; 2007 Jan 12; 1128(1):175-80. PubMed ID: 17123488
    [Abstract] [Full Text] [Related]

  • 9. Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion.
    Koumura A, Hamanaka J, Kawasaki K, Tsuruma K, Shimazawa M, Hozumi I, Inuzuka T, Hara H.
    J Pharmacol Exp Ther; 2011 Jul 12; 338(1):337-44. PubMed ID: 21493751
    [Abstract] [Full Text] [Related]

  • 10. Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model.
    Satoh S, Toshima Y, Hitomi A, Ikegaki I, Seto M, Asano T.
    Brain Res; 2008 Feb 08; 1193():102-8. PubMed ID: 18187127
    [Abstract] [Full Text] [Related]

  • 11. Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage.
    Satoh S, Utsunomiya T, Tsurui K, Kobayashi T, Ikegaki I, Sasaki Y, Asano T.
    Life Sci; 2001 Aug 10; 69(12):1441-53. PubMed ID: 11531167
    [Abstract] [Full Text] [Related]

  • 12. Neuroprotective potential of fasudil mesylate in brain ischemia-reperfusion injury of rats.
    Li Q, Huang XJ, He W, Ding J, Jia JT, Fu G, Wang HX, Guo LJ.
    Cell Mol Neurobiol; 2009 Mar 10; 29(2):169-80. PubMed ID: 18785000
    [Abstract] [Full Text] [Related]

  • 13. Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina.
    Kitaoka Y, Kitaoka Y, Kumai T, Lam TT, Kuribayashi K, Isenoumi K, Munemasa Y, Motoki M, Kobayashi S, Ueno S.
    Brain Res; 2004 Aug 20; 1018(1):111-8. PubMed ID: 15262212
    [Abstract] [Full Text] [Related]

  • 14. Improvement of cognitive deficit and neuronal damage in rats with chronic cerebral ischemia via relative long-term inhibition of rho-kinase.
    Huang L, He Z, Guo L, Wang H.
    Cell Mol Neurobiol; 2008 Aug 20; 28(5):757-68. PubMed ID: 17554619
    [Abstract] [Full Text] [Related]

  • 15. Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage.
    Satoh S, Hitomi A, Ikegaki I, Kawasaki K, Nakazono O, Iwasaki M, Mohri M, Asano T.
    Brain Res Bull; 2010 Jan 15; 81(1):191-5. PubMed ID: 19723568
    [Abstract] [Full Text] [Related]

  • 16. Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms.
    Shin HK, Salomone S, Potts EM, Lee SW, Millican E, Noma K, Huang PL, Boas DA, Liao JK, Moskowitz MA, Ayata C.
    J Cereb Blood Flow Metab; 2007 May 15; 27(5):998-1009. PubMed ID: 17033691
    [Abstract] [Full Text] [Related]

  • 17. Rho-kinase inhibitor prevents acute injury against transient focal cerebral ischemia by enhancing the expression and function of GABA receptors in rats.
    Huang L, Li Q, Wen R, Yu Z, Li N, Ma L, Feng W.
    Eur J Pharmacol; 2017 Feb 15; 797():134-142. PubMed ID: 28109911
    [Abstract] [Full Text] [Related]

  • 18. Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats.
    Jiang BH, Tawara S, Abe K, Takaki A, Fukumoto Y, Shimokawa H.
    J Cardiovasc Pharmacol; 2007 Feb 15; 49(2):85-9. PubMed ID: 17312448
    [Abstract] [Full Text] [Related]

  • 19. Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.
    Levent A, Büyükafsar K.
    Br J Pharmacol; 2004 Oct 15; 143(3):431-7. PubMed ID: 15351780
    [Abstract] [Full Text] [Related]

  • 20. Role of Rho Kinase and Fasudil on Synaptic Plasticity in Multiple Sclerosis.
    Chen C, Yu JZ, Zhang Q, Zhao YF, Liu CY, Li YH, Yang WF, Ma CG, Xiao BG.
    Neuromolecular Med; 2015 Dec 15; 17(4):454-65. PubMed ID: 26481340
    [Abstract] [Full Text] [Related]

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