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Journal Abstract Search

111 related items for PubMed ID: 17493759

  • 1. Importance of a hypervariable active-site residue in human Mu class glutathione transferases catalyzing the bioactivation of chemotherapeutic thiopurine prodrugs.
    Eklund BI, Mannervik B.
    Biochim Biophys Acta; 2007 Aug; 1770(8):1098-103. PubMed ID: 17493759
    [Abstract] [Full Text] [Related]

  • 2. Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs.
    Eklund BI, Gunnarsdottir S, Elfarra AA, Mannervik B.
    Biochem Pharmacol; 2007 Jun 01; 73(11):1829-41. PubMed ID: 17433263
    [Abstract] [Full Text] [Related]

  • 3. Regio- and enantioselectivities in epoxide conjugations are modulated by residue 210 in Mu class glutathione transferases.
    Ivarsson Y, Mannervik B.
    Protein Eng Des Sel; 2005 Dec 01; 18(12):607-16. PubMed ID: 16251220
    [Abstract] [Full Text] [Related]

  • 4. Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine.
    Zhang W, Modén O, Mannervik B.
    Chem Biol Interact; 2010 Jul 30; 186(2):110-7. PubMed ID: 20434437
    [Abstract] [Full Text] [Related]

  • 5. Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine.
    Modén O, Zhang W, Mannervik B.
    Protein Eng Des Sel; 2012 Apr 30; 25(4):189-97. PubMed ID: 22334756
    [Abstract] [Full Text] [Related]

  • 6. Glutathione transferases in the bioactivation of azathioprine.
    Modén O, Mannervik B.
    Adv Cancer Res; 2014 Apr 30; 122():199-244. PubMed ID: 24974183
    [Abstract] [Full Text] [Related]

  • 7. Glutathione transferase activity with a novel substrate mimics the activation of the prodrug azathioprine.
    Kurtovic S, Grehn L, Karlsson A, Hellman U, Mannervik B.
    Anal Biochem; 2008 Apr 15; 375(2):339-44. PubMed ID: 18211812
    [Abstract] [Full Text] [Related]

  • 8. Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members.
    Kurtovic S, Modén O, Shokeer A, Mannervik B.
    J Mol Biol; 2008 Feb 01; 375(5):1365-79. PubMed ID: 18155239
    [Abstract] [Full Text] [Related]

  • 9. Evolution of differential substrate specificities in Mu class glutathione transferases probed by DNA shuffling.
    Hansson LO, Bolton-Grob R, Massoud T, Mannervik B.
    J Mol Biol; 1999 Mar 26; 287(2):265-76. PubMed ID: 10080890
    [Abstract] [Full Text] [Related]

  • 10. A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes.
    Comstock KE, Widersten M, Hao XY, Henner WD, Mannervik B.
    Arch Biochem Biophys; 1994 Jun 26; 311(2):487-95. PubMed ID: 8203914
    [Abstract] [Full Text] [Related]

  • 11. Engineering GST M2-2 for high activity with indene 1,2-oxide and indication of an H-site residue sustaining catalytic promiscuity.
    Norrgård MA, Mannervik B.
    J Mol Biol; 2011 Sep 09; 412(1):111-20. PubMed ID: 21821040
    [Abstract] [Full Text] [Related]

  • 12. Multivariate-activity mining for molecular quasi-species in a glutathione transferase mutant library.
    Kurtovic S, Runarsdottir A, Emrén LO, Larsson AK, Mannervik B.
    Protein Eng Des Sel; 2007 May 09; 20(5):243-56. PubMed ID: 17468114
    [Abstract] [Full Text] [Related]

  • 13. Contribution of amino acid residue 208 in the hydrophobic binding site to the catalytic mechanism of human glutathione transferase A1-1.
    Widersten M, Björnestedt R, Mannervik B.
    Biochemistry; 1994 Oct 04; 33(39):11717-23. PubMed ID: 7918388
    [Abstract] [Full Text] [Related]

  • 14. Mechanism-based phage display selection of active-site mutants of human glutathione transferase A1-1 catalyzing SNAr reactions.
    Hansson LO, Widersten M, Mannervik B.
    Biochemistry; 1997 Sep 16; 36(37):11252-60. PubMed ID: 9287168
    [Abstract] [Full Text] [Related]

  • 15. Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screen.
    Gunnarsdottir S, Elfarra AA.
    Drug Metab Dispos; 2004 Mar 16; 32(3):321-7. PubMed ID: 14977866
    [Abstract] [Full Text] [Related]

  • 16. A novel quasi-species of glutathione transferase with high activity towards naturally occurring isothiocyanates evolves from promiscuous low-activity variants.
    Runarsdottir A, Mannervik B.
    J Mol Biol; 2010 Aug 20; 401(3):451-64. PubMed ID: 20600121
    [Abstract] [Full Text] [Related]

  • 17. Divergent activities of human glutathione transferases in the bioactivation of azathioprine.
    Eklund BI, Moberg M, Bergquist J, Mannervik B.
    Mol Pharmacol; 2006 Aug 20; 70(2):747-54. PubMed ID: 16717136
    [Abstract] [Full Text] [Related]

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  • 20. Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1.
    Shokeer A, Mannervik B.
    Biochim Biophys Acta; 2010 Apr 20; 1800(4):466-73. PubMed ID: 20097269
    [Abstract] [Full Text] [Related]

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