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Journal Abstract Search

1045 related items for PubMed ID: 17496923

  • 1. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.
    Roberts PJ, Der CJ.
    Oncogene; 2007 May 14; 26(22):3291-310. PubMed ID: 17496923
    [Abstract] [Full Text] [Related]

  • 2. Advances in targeting the Ras/Raf/MEK/Erk mitogen-activated protein kinase cascade with MEK inhibitors for cancer therapy.
    Friday BB, Adjei AA.
    Clin Cancer Res; 2008 Jan 15; 14(2):342-6. PubMed ID: 18223206
    [Abstract] [Full Text] [Related]

  • 3. Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors.
    McCubrey JA, Milella M, Tafuri A, Martelli AM, Lunghi P, Bonati A, Cervello M, Lee JT, Steelman LS.
    Curr Opin Investig Drugs; 2008 Jun 15; 9(6):614-30. PubMed ID: 18516761
    [Abstract] [Full Text] [Related]

  • 4. Targeting the RAF-MEK-ERK pathway in cancer therapy.
    Montagut C, Settleman J.
    Cancer Lett; 2009 Oct 08; 283(2):125-34. PubMed ID: 19217204
    [Abstract] [Full Text] [Related]

  • 5. Raf: a strategic target for therapeutic development against cancer.
    Beeram M, Patnaik A, Rowinsky EK.
    J Clin Oncol; 2005 Sep 20; 23(27):6771-90. PubMed ID: 16170185
    [Abstract] [Full Text] [Related]

  • 6. Pharmacologic inhibition of RAF-->MEK-->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1.
    Gysin S, Lee SH, Dean NM, McMahon M.
    Cancer Res; 2005 Jun 01; 65(11):4870-80. PubMed ID: 15930308
    [Abstract] [Full Text] [Related]

  • 7. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.
    Liu L, Cao Y, Chen C, Zhang X, McNabola A, Wilkie D, Wilhelm S, Lynch M, Carter C.
    Cancer Res; 2006 Dec 15; 66(24):11851-8. PubMed ID: 17178882
    [Abstract] [Full Text] [Related]

  • 8. Activation and role of MAP kinase-dependent pathways in retinal pigment epithelial cells: ERK and RPE cell proliferation.
    Hecquet C, Lefevre G, Valtink M, Engelmann K, Mascarelli F.
    Invest Ophthalmol Vis Sci; 2002 Sep 15; 43(9):3091-8. PubMed ID: 12202534
    [Abstract] [Full Text] [Related]

  • 9. Targeting Raf/MEK/ERK pathway in pituitary adenomas.
    Suojun Z, Feng W, Dongsheng G, Ting L.
    Eur J Cancer; 2012 Feb 15; 48(3):389-95. PubMed ID: 22119203
    [Abstract] [Full Text] [Related]

  • 10. Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1.
    Kogut MH, Genovese KJ, He H.
    Mol Immunol; 2007 Mar 15; 44(7):1729-36. PubMed ID: 17045653
    [Abstract] [Full Text] [Related]

  • 11. Activation of the RAF/mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway mediates apoptosis induced by chelerythrine in osteosarcoma.
    Yang R, Piperdi S, Gorlick R.
    Clin Cancer Res; 2008 Oct 15; 14(20):6396-404. PubMed ID: 18927278
    [Abstract] [Full Text] [Related]

  • 12. Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
    Gollob JA, Wilhelm S, Carter C, Kelley SL.
    Semin Oncol; 2006 Aug 15; 33(4):392-406. PubMed ID: 16890795
    [Abstract] [Full Text] [Related]

  • 13. Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines.
    Ulivi P, Arienti C, Amadori D, Fabbri F, Carloni S, Tesei A, Vannini I, Silvestrini R, Zoli W.
    J Cell Physiol; 2009 Jul 15; 220(1):214-21. PubMed ID: 19288493
    [Abstract] [Full Text] [Related]

  • 14. Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells.
    Yip-Schneider MT, Klein PJ, Wentz SC, Zeni A, Menze A, Schmidt CM.
    J Pharmacol Exp Ther; 2009 Jun 15; 329(3):1063-70. PubMed ID: 19258520
    [Abstract] [Full Text] [Related]

  • 15. Akt regulates vitamin D3-induced leukemia cell functional differentiation via Raf/MEK/ERK MAPK signaling.
    Wang J, Zhao Y, Kauss MA, Spindel S, Lian H.
    Eur J Cell Biol; 2009 Feb 15; 88(2):103-15. PubMed ID: 19058874
    [Abstract] [Full Text] [Related]

  • 16. Raf-1 kinase activation is uncoupled from downstream MEK/ERK pathway in cells treated with Src tyrosine kinase inhibitor PP2.
    Lee M.
    Biochem Biophys Res Commun; 2006 Nov 17; 350(2):450-6. PubMed ID: 17010316
    [Abstract] [Full Text] [Related]

  • 17. Lead acetate induces EGFR activation upstream of SFK and PKCalpha linkage to the Ras/Raf-1/ERK signaling.
    Wang CY, Wang YT, Tzeng DW, Yang JL.
    Toxicol Appl Pharmacol; 2009 Mar 01; 235(2):244-52. PubMed ID: 19133285
    [Abstract] [Full Text] [Related]

  • 18. [Effects of extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activation on proliferation and cell cycle associated genes in human colon cancer cells].
    Wang X, Lu R, Fang JY.
    Zhonghua Yi Xue Za Zhi; 2007 Apr 10; 87(14):982-6. PubMed ID: 17650425
    [Abstract] [Full Text] [Related]

  • 19. PKC isoenzymes differentially modulate the effect of thrombin on MAPK-dependent RPE proliferation.
    Palma-Nicolas JP, López E, López-Colomé AM.
    Biosci Rep; 2008 Dec 10; 28(6):307-17. PubMed ID: 18636965
    [Abstract] [Full Text] [Related]

  • 20. Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature.
    Adnane L, Trail PA, Taylor I, Wilhelm SM.
    Methods Enzymol; 2006 Dec 10; 407():597-612. PubMed ID: 16757355
    [Abstract] [Full Text] [Related]

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