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Journal Abstract Search

365 related items for PubMed ID: 17510425

  • 1. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.
    Schepelmann S, Ogilvie LM, Hedley D, Friedlos F, Martin J, Scanlon I, Chen P, Marais R, Springer CJ.
    Cancer Res; 2007 May 15; 67(10):4949-55. PubMed ID: 17510425
    [Abstract] [Full Text] [Related]

  • 2. Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2.
    Schepelmann S, Hallenbeck P, Ogilvie LM, Hedley D, Friedlos F, Martin J, Scanlon I, Hay C, Hawkins LK, Marais R, Springer CJ.
    Cancer Res; 2005 Jun 15; 65(12):5003-8. PubMed ID: 15958540
    [Abstract] [Full Text] [Related]

  • 3. Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.
    Friedlos F, Lehouritis P, Ogilvie L, Hedley D, Davies L, Bermudes D, King I, Martin J, Marais R, Springer CJ.
    Clin Cancer Res; 2008 Jul 01; 14(13):4259-66. PubMed ID: 18594008
    [Abstract] [Full Text] [Related]

  • 4. Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models.
    Friedlos F, Davies L, Scanlon I, Ogilvie LM, Martin J, Stribbling SM, Spooner RA, Niculescu-Duvaz I, Marais R, Springer CJ.
    Cancer Res; 2002 Mar 15; 62(6):1724-9. PubMed ID: 11912146
    [Abstract] [Full Text] [Related]

  • 5. Self-immolative nitrogen mustard prodrugs for suicide gene therapy.
    Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, Martin J, Spooner R, Davies L, Marais R, Springer CJ.
    J Med Chem; 1998 Dec 17; 41(26):5297-309. PubMed ID: 9857097
    [Abstract] [Full Text] [Related]

  • 6. In suicide gene therapy, the site of subcellular localization of the activating enzyme is more important than the rate at which it activates prodrug.
    Spooner RA, Martin J, Friedlos F, Marais R, Springer CJ.
    Cancer Gene Ther; 2000 Oct 17; 7(10):1348-56. PubMed ID: 11059693
    [Abstract] [Full Text] [Related]

  • 7. Adenovirus vector-mediated delivery of the prodrug-converting enzyme carboxypeptidase G2 in a secreted or GPI-anchored form: High-level expression of this active conditional cytotoxic enzyme at the plasma membrane.
    Cowen RL, Williams JC, Emery S, Blakey D, Darling JL, Lowenstein PR, Castro MG.
    Cancer Gene Ther; 2002 Nov 17; 9(11):897-907. PubMed ID: 12386828
    [Abstract] [Full Text] [Related]

  • 8. Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy.
    Davies LC, Friedlos F, Hedley D, Martin J, Ogilvie LM, Scanlon IJ, Springer CJ.
    J Med Chem; 2005 Aug 11; 48(16):5321-8. PubMed ID: 16078849
    [Abstract] [Full Text] [Related]

  • 9. Significant differences in biological parameters between prodrugs cleavable by carboxypeptidase G2 that generate 3,5-difluoro-phenol and -aniline nitrogen mustards in gene-directed enzyme prodrug therapy systems.
    Niculescu-Duvaz I, Scanlon I, Niculescu-Duvaz D, Friedlos F, Martin J, Marais R, Springer CJ.
    J Med Chem; 2004 May 06; 47(10):2651-8. PubMed ID: 15115406
    [Abstract] [Full Text] [Related]

  • 10. A novel technique to monitor carboxypeptidase G2 expression in suicide gene therapy using 19F magnetic resonance spectroscopy.
    Mancini L, Davies L, Friedlos F, Falck-Miniotis M, Dzik-Jurasz AS, Springer CJ, Leach MO, Payne GS.
    NMR Biomed; 2009 Jun 06; 22(5):561-6. PubMed ID: 19259950
    [Abstract] [Full Text] [Related]

  • 11. Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination.
    Marais R, Spooner RA, Light Y, Martin J, Springer CJ.
    Cancer Res; 1996 Oct 15; 56(20):4735-42. PubMed ID: 8840992
    [Abstract] [Full Text] [Related]

  • 12. Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT.
    Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, Martin J, Lehouritis P, Marais R, Springer CJ.
    J Med Chem; 2003 Apr 24; 46(9):1690-705. PubMed ID: 12699387
    [Abstract] [Full Text] [Related]

  • 13. A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy.
    Marais R, Spooner RA, Stribbling SM, Light Y, Martin J, Springer CJ.
    Nat Biotechnol; 1997 Dec 24; 15(13):1373-7. PubMed ID: 9415889
    [Abstract] [Full Text] [Related]

  • 14. [The efficacy of autocatalytic casapse-3 driven by human telomerase reverse transcriptase promoter on human ovarian carcinoma].
    Song Y, Shen K, Yu JR.
    Zhonghua Yi Xue Za Zhi; 2007 Nov 06; 87(41):2919-24. PubMed ID: 18261307
    [Abstract] [Full Text] [Related]

  • 15. The nitroreductase prodrug SN 28343 enhances the potency of systemically administered armed oncolytic adenovirus ONYX-411(NTR).
    Singleton DC, Li D, Bai SY, Syddall SP, Smaill JB, Shen Y, Denny WA, Wilson WR, Patterson AV.
    Cancer Gene Ther; 2007 Dec 06; 14(12):953-67. PubMed ID: 17975564
    [Abstract] [Full Text] [Related]

  • 16. Oncolytic adenovirus that overproduces ADP and replicates selectively in tumors due to hTERT promoter-regulated E4 gene expression.
    Kuppuswamy M, Spencer JF, Doronin K, Tollefson AE, Wold WS, Toth K.
    Gene Ther; 2005 Nov 06; 12(22):1608-17. PubMed ID: 16034456
    [Abstract] [Full Text] [Related]

  • 17. Treatment of patient tumor-derived colon cancer xenografts by a TRAIL gene-armed oncolytic adenovirus.
    Zhou W, Zhu H, Chen W, Hu X, Pang X, Zhang J, Huang X, Fang B, He C.
    Cancer Gene Ther; 2011 May 06; 18(5):336-45. PubMed ID: 21183948
    [Abstract] [Full Text] [Related]

  • 18. Antibody-directed enzyme prodrug therapy: efficacy and mechanism of action in colorectal carcinoma.
    Napier MP, Sharma SK, Springer CJ, Bagshawe KD, Green AJ, Martin J, Stribbling SM, Cushen N, O'Malley D, Begent RH.
    Clin Cancer Res; 2000 Mar 06; 6(3):765-72. PubMed ID: 10741695
    [Abstract] [Full Text] [Related]

  • 19. Gene-directed enzyme prodrug therapy with carboxylesterase enhances the anticancer efficacy of the conditionally replicating adenovirus AdDelta24.
    Oosterhoff D, Pinedo HM, Witlox MA, Carette JE, Gerritsen WR, van Beusechem VW.
    Gene Ther; 2005 Jun 06; 12(12):1011-8. PubMed ID: 15729367
    [Abstract] [Full Text] [Related]

  • 20. [Construction of autocatalytic caspase-3 driven by amplified human telomerase reverse transcriptase promoter and its enhanced efficacy of inducing apoptosis in human ovarian carcinoma].
    Song Y, Shen K, He CX.
    Zhonghua Fu Chan Ke Za Zhi; 2007 Sep 06; 42(9):617-22. PubMed ID: 17983518
    [Abstract] [Full Text] [Related]

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