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Journal Abstract Search

515 related items for PubMed ID: 17532631

  • 1. Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.
    Lin R, Connolly PJ, Lu Y, Chiu G, Li S, Yu Y, Huang S, Li X, Emanuel SL, Middleton SA, Gruninger RH, Adams M, Fuentes-Pesquera AR, Greenberger LM.
    Bioorg Med Chem Lett; 2007 Aug 01; 17(15):4297-302. PubMed ID: 17532631
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors.
    Lin R, Chiu G, Yu Y, Connolly PJ, Li S, Lu Y, Adams M, Fuentes-Pesquera AR, Emanuel SL, Greenberger LM.
    Bioorg Med Chem Lett; 2007 Aug 15; 17(16):4557-61. PubMed ID: 17574416
    [Abstract] [Full Text] [Related]

  • 3. Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases.
    Braña MF, Cacho M, García ML, Mayoral EP, López B, de Pascual-Teresa B, Ramos A, Acero N, Llinares F, Muñoz-Mingarro D, Lozach O, Meijer L.
    J Med Chem; 2005 Nov 03; 48(22):6843-54. PubMed ID: 16250643
    [Abstract] [Full Text] [Related]

  • 4. Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents.
    Jacquemard U, Dias N, Lansiaux A, Bailly C, Logé C, Robert JM, Lozach O, Meijer L, Mérour JY, Routier S.
    Bioorg Med Chem; 2008 May 01; 16(9):4932-53. PubMed ID: 18439832
    [Abstract] [Full Text] [Related]

  • 5. Identification of potent pyrazolo[4,3-h]quinazoline-3-carboxamides as multi-cyclin-dependent kinase inhibitors.
    Traquandi G, Ciomei M, Ballinari D, Casale E, Colombo N, Croci V, Fiorentini F, Isacchi A, Longo A, Mercurio C, Panzeri A, Pastori W, Pevarello P, Volpi D, Roussel P, Vulpetti A, Brasca MG.
    J Med Chem; 2010 Mar 11; 53(5):2171-87. PubMed ID: 20141146
    [Abstract] [Full Text] [Related]

  • 6. Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitors.
    Shi J, Xu G, Zhu W, Ye H, Yang S, Luo Y, Han J, Yang J, Li R, Wei Y, Chen L.
    Bioorg Med Chem Lett; 2010 Jul 15; 20(14):4273-8. PubMed ID: 20621733
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines.
    Ahmed OM, Mohamed MA, Ahmed RR, Ahmed SA.
    Eur J Med Chem; 2009 Sep 15; 44(9):3519-23. PubMed ID: 19398146
    [Abstract] [Full Text] [Related]

  • 8. Nitrogen-containing flavonoids as CDK1/Cyclin B inhibitors: design, synthesis, and biological evaluation.
    Liu T, Xu Z, He Q, Chen Y, Yang B, Hu Y.
    Bioorg Med Chem Lett; 2007 Jan 01; 17(1):278-81. PubMed ID: 17085048
    [Abstract] [Full Text] [Related]

  • 9. Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors.
    Kendall JD, O'Connor PD, Marshall AJ, Frédérick R, Marshall ES, Lill CL, Lee WJ, Kolekar S, Chao M, Malik A, Yu S, Chaussade C, Buchanan C, Rewcastle GW, Baguley BC, Flanagan JU, Jamieson SM, Denny WA, Shepherd PR.
    Bioorg Med Chem; 2012 Jan 01; 20(1):69-85. PubMed ID: 22177405
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors.
    Chen S, Chen L, Le NT, Zhao C, Sidduri A, Lou JP, Michoud C, Portland L, Jackson N, Liu JJ, Konzelmann F, Chi F, Tovar C, Xiang Q, Chen Y, Wen Y, Vassilev LT.
    Bioorg Med Chem Lett; 2007 Apr 15; 17(8):2134-8. PubMed ID: 17303421
    [Abstract] [Full Text] [Related]

  • 11. Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt.
    Zhu GD, Gong J, Gandhi VB, Woods K, Luo Y, Liu X, Guan R, Klinghofer V, Johnson EF, Stoll VS, Mamo M, Li Q, Rosenberg SH, Giranda VL.
    Bioorg Med Chem; 2007 Mar 15; 15(6):2441-52. PubMed ID: 17258463
    [Abstract] [Full Text] [Related]

  • 12. Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases.
    Claridge S, Raeppel F, Granger MC, Bernstein N, Saavedra O, Zhan L, Llewellyn D, Wahhab A, Deziel R, Rahil J, Beaulieu N, Nguyen H, Dupont I, Barsalou A, Beaulieu C, Chute I, Gravel S, Robert MF, Lefebvre S, Dubay M, Pascal R, Gillespie J, Jin Z, Wang J, Besterman JM, MacLeod AR, Vaisburg A.
    Bioorg Med Chem Lett; 2008 May 01; 18(9):2793-8. PubMed ID: 18434145
    [Abstract] [Full Text] [Related]

  • 13. Discovery and optimization of N-acyl and N-aroylpyrazolines as B-Raf kinase inhibitors.
    Blackburn C, Duffey MO, Gould AE, Kulkarni B, Liu JX, Menon S, Nagayoshi M, Vos TJ, Williams J.
    Bioorg Med Chem Lett; 2010 Aug 15; 20(16):4795-9. PubMed ID: 20630752
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis and biological evaluation of new potent and highly selective ROS1-tyrosine kinase inhibitor.
    Park BS, El-Deeb IM, Yoo KH, Oh CH, Cho SJ, Han DK, Lee HS, Lee JY, Lee SH.
    Bioorg Med Chem Lett; 2009 Aug 15; 19(16):4720-3. PubMed ID: 19596575
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors.
    Chioua M, Samadi A, Soriano E, Lozach O, Meijer L, Marco-Contelles J.
    Bioorg Med Chem Lett; 2009 Aug 15; 19(16):4566-9. PubMed ID: 19615897
    [Abstract] [Full Text] [Related]

  • 16. Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors.
    Dwyer MP, Paruch K, Alvarez C, Doll RJ, Keertikar K, Duca J, Fischmann TO, Hruza A, Madison V, Lees E, Parry D, Seghezzi W, Sgambellone N, Shanahan F, Wiswell D, Guzi TJ.
    Bioorg Med Chem Lett; 2007 Nov 15; 17(22):6216-9. PubMed ID: 17904366
    [Abstract] [Full Text] [Related]

  • 17. Pyrazolo[1,5-a]pyridines as p38 kinase inhibitors.
    Stevens KL, Jung DK, Alberti MJ, Badiang JG, Peckham GE, Veal JM, Cheung M, Harris PA, Chamberlain SD, Peel MR.
    Org Lett; 2005 Oct 13; 7(21):4753-6. PubMed ID: 16209527
    [Abstract] [Full Text] [Related]

  • 18. 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases.
    Misra RN, Rawlins DB, Xiao HY, Shan W, Bursuker I, Kellar KA, Mulheron JG, Sack JS, Tokarski JS, Kimball SD, Webster KR.
    Bioorg Med Chem Lett; 2003 Mar 24; 13(6):1133-6. PubMed ID: 12643928
    [Abstract] [Full Text] [Related]

  • 19. Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity.
    Schultz C, Link A, Leost M, Zaharevitz DW, Gussio R, Sausville EA, Meijer L, Kunick C.
    J Med Chem; 1999 Jul 29; 42(15):2909-19. PubMed ID: 10425100
    [Abstract] [Full Text] [Related]

  • 20. Synthesis of pyrazolo[3,4-b]pyridines under microwave irradiation in multi-component reactions and their antitumor and antimicrobial activities - Part 1.
    El-borai MA, Rizk HF, Abd-Aal MF, El-Deeb IY.
    Eur J Med Chem; 2012 Feb 29; 48():92-6. PubMed ID: 22178093
    [Abstract] [Full Text] [Related]

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