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246 related items for PubMed ID: 17533421

  • 1. Combined pharmacological block of I(Kr) and I(Ks) increases short-term QT interval variability and provokes torsades de pointes.
    Lengyel C, Varró A, Tábori K, Papp JG, Baczkó I.
    Br J Pharmacol; 2007 Aug; 151(7):941-51. PubMed ID: 17533421
    [Abstract] [Full Text] [Related]

  • 2. Double pharmacological challenge on repolarization opens new avenues for drug safety research.
    Thomsen MB.
    Br J Pharmacol; 2007 Aug; 151(7):909-11. PubMed ID: 17549050
    [Abstract] [Full Text] [Related]

  • 3. Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation.
    Michael G, Dempster J, Kane KA, Coker SJ.
    Br J Pharmacol; 2007 Dec; 152(8):1215-27. PubMed ID: 17965747
    [Abstract] [Full Text] [Related]

  • 4. Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs.
    Michael G, Kane KA, Coker SJ.
    Br J Pharmacol; 2008 Aug; 154(7):1414-26. PubMed ID: 18493252
    [Abstract] [Full Text] [Related]

  • 5. New in vitro model for proarrhythmia safety screening: IKs inhibition potentiates the QTc prolonging effect of IKr inhibitors in isolated guinea pig hearts.
    Kui P, Orosz S, Takács H, Sarusi A, Csík N, Rárosi F, Csekő C, Varró A, Papp JG, Forster T, Farkas AS, Farkas A.
    J Pharmacol Toxicol Methods; 2016 Aug; 80():26-34. PubMed ID: 27063345
    [Abstract] [Full Text] [Related]

  • 6. Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit.
    Jacobson I, Carlsson L, Duker G.
    J Pharmacol Toxicol Methods; 2011 Aug; 63(1):40-6. PubMed ID: 20451633
    [Abstract] [Full Text] [Related]

  • 7. Slow delayed rectifier K+ current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles.
    So PP, Backx PH, Dorian P.
    Br J Pharmacol; 2008 Dec; 155(8):1185-94. PubMed ID: 18836478
    [Abstract] [Full Text] [Related]

  • 8. Assessment of efficacy of proarrhythmia biomarkers in isolated rabbit hearts with attenuated repolarization reserve.
    Orosz S, Sarusi A, Csík N, Papp JG, Varró A, Farkas S, Forster T, Farkas AS, Farkas A.
    J Cardiovasc Pharmacol; 2014 Sep; 64(3):266-76. PubMed ID: 24887684
    [Abstract] [Full Text] [Related]

  • 9. Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts.
    Cheng HC, Incardona J.
    J Pharmacol Toxicol Methods; 2009 Sep; 60(2):174-84. PubMed ID: 19524054
    [Abstract] [Full Text] [Related]

  • 10. A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs).
    Lu HR, Yan GX, Gallacher DJ.
    J Pharmacol Toxicol Methods; 2013 Sep; 68(2):250-259. PubMed ID: 23337247
    [Abstract] [Full Text] [Related]

  • 11. Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes.
    Thomsen MB, Volders PG, Beekman JD, Matz J, Vos MA.
    J Am Coll Cardiol; 2006 Sep 19; 48(6):1268-76. PubMed ID: 16979017
    [Abstract] [Full Text] [Related]

  • 12. Nonselective I(Kr)-blockers do not induce torsades de pointes in the anesthetized rabbit during alpha1-adrenoceptor stimulation.
    Lu HR, Remeysen P, De Clerck F.
    J Cardiovasc Pharmacol; 2000 Dec 19; 36(6):728-36. PubMed ID: 11117372
    [Abstract] [Full Text] [Related]

  • 13. The electromechanical window is no better than QT prolongation to assess risk of Torsade de Pointes in the complete atrioventricular block model in dogs.
    Stams TR, Bourgonje VJ, Beekman HD, Schoenmakers M, van der Nagel R, Oosterhoff P, van Opstal JM, Vos MA.
    Br J Pharmacol; 2014 Feb 19; 171(3):714-22. PubMed ID: 24490860
    [Abstract] [Full Text] [Related]

  • 14. Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome.
    Diness TG, Yeh YH, Qi XY, Chartier D, Tsuji Y, Hansen RS, Olesen SP, Grunnet M, Nattel S.
    Cardiovasc Res; 2008 Jul 01; 79(1):61-9. PubMed ID: 18367457
    [Abstract] [Full Text] [Related]

  • 15. Combined inhibition of key potassium currents has different effects on cardiac repolarization reserve and arrhythmia susceptibility in dogs and rabbits.
    Husti Z, Tábori K, Juhász V, Hornyik T, Varró A, Baczkó I.
    Can J Physiol Pharmacol; 2015 Jul 01; 93(7):535-44. PubMed ID: 25928472
    [Abstract] [Full Text] [Related]

  • 16. Calcium antagonist property of CPU228, a dofetilide derivative, contributes to its low incidence of torsades de pointes in rabbits.
    Huang ZJ, Dai DZ, Li N, Na T, Ji M, Dai Y.
    Clin Exp Pharmacol Physiol; 2007 Apr 01; 34(4):310-7. PubMed ID: 17324143
    [Abstract] [Full Text] [Related]

  • 17. K201, a multi-channel blocker, inhibits clofilium-induced torsades de pointes and attenuates an increase in repolarization.
    Hasumi H, Matsuda R, Shimamoto K, Hata Y, Kaneko N.
    Eur J Pharmacol; 2007 Jan 19; 555(1):54-60. PubMed ID: 17112502
    [Abstract] [Full Text] [Related]

  • 18. The role of the Na+/Ca2+ exchanger, I(Na) and I(CaL) in the genesis of dofetilide-induced torsades de pointes in isolated, AV-blocked rabbit hearts.
    Farkas AS, Makra P, Csík N, Orosz S, Shattock MJ, Fülöp F, Forster T, Csanády M, Papp JG, Varró A, Farkas A.
    Br J Pharmacol; 2009 Mar 19; 156(6):920-32. PubMed ID: 19222480
    [Abstract] [Full Text] [Related]

  • 19. Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation.
    Thomsen MB, Oros A, Schoenmakers M, van Opstal JM, Maas JN, Beekman JD, Vos MA.
    Cardiovasc Res; 2007 Feb 01; 73(3):521-30. PubMed ID: 17196569
    [Abstract] [Full Text] [Related]

  • 20. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development.
    Redfern WS, Carlsson L, Davis AS, Lynch WG, MacKenzie I, Palethorpe S, Siegl PK, Strang I, Sullivan AT, Wallis R, Camm AJ, Hammond TG.
    Cardiovasc Res; 2003 Apr 01; 58(1):32-45. PubMed ID: 12667944
    [Abstract] [Full Text] [Related]

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