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Journal Abstract Search

786 related items for PubMed ID: 17536186

  • 1. Immunotherapy against APP beta-secretase cleavage site improves cognitive function and reduces neuroinflammation in Tg2576 mice without a significant effect on brain abeta levels.
    Rakover I, Arbel M, Solomon B.
    Neurodegener Dis; 2007; 4(5):392-402. PubMed ID: 17536186
    [Abstract] [Full Text] [Related]

  • 2. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I, Hawkins J, Harrison D, Hille C, Wayne G, Cutler L, Buck T, Walter D, Demont E, Howes C, Naylor A, Jeffrey P, Gonzalez MI, Dingwall C, Michel A, Redshaw S, Davis JB.
    J Neurochem; 2007 Feb; 100(3):802-9. PubMed ID: 17156133
    [Abstract] [Full Text] [Related]

  • 3. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.
    J Neurosci Res; 2003 Nov 01; 74(3):386-92. PubMed ID: 14598315
    [Abstract] [Full Text] [Related]

  • 4. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
    Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.
    J Pharmacol Exp Ther; 2008 Mar 01; 324(3):957-69. PubMed ID: 18156464
    [Abstract] [Full Text] [Related]

  • 5. Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production.
    Arendash GW, Schleif W, Rezai-Zadeh K, Jackson EK, Zacharia LC, Cracchiolo JR, Shippy D, Tan J.
    Neuroscience; 2006 Nov 03; 142(4):941-52. PubMed ID: 16938404
    [Abstract] [Full Text] [Related]

  • 6. Novel approaches for immunotherapeutic intervention in Alzheimer's disease.
    Vasilevko V, Cribbs DH.
    Neurochem Int; 2006 Jul 03; 49(2):113-26. PubMed ID: 16765487
    [Abstract] [Full Text] [Related]

  • 7. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.
    J Pharmacol Exp Ther; 2009 Nov 03; 331(2):598-608. PubMed ID: 19671883
    [Abstract] [Full Text] [Related]

  • 8. Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP.
    Boddapati S, Levites Y, Sierks MR.
    J Mol Biol; 2011 Jan 14; 405(2):436-47. PubMed ID: 21073877
    [Abstract] [Full Text] [Related]

  • 9. The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.
    Asai M, Hattori C, Iwata N, Saido TC, Sasagawa N, Szabó B, Hashimoto Y, Maruyama K, Tanuma S, Kiso Y, Ishiura S.
    J Neurochem; 2006 Jan 14; 96(2):533-40. PubMed ID: 16336629
    [Abstract] [Full Text] [Related]

  • 10. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
    Imbimbo BP, Del Giudice E, Colavito D, D'Arrigo A, Dalle Carbonare M, Villetti G, Facchinetti F, Volta R, Pietrini V, Baroc MF, Serneels L, De Strooper B, Leon A.
    J Pharmacol Exp Ther; 2007 Dec 14; 323(3):822-30. PubMed ID: 17895400
    [Abstract] [Full Text] [Related]

  • 11. Age-dependent differential expression of BACE splice variants in brain regions of tg2576 mice.
    Zohar O, Pick CG, Cavallaro S, Chapman J, Katzav A, Milman A, Alkon DL.
    Neurobiol Aging; 2005 Dec 14; 26(8):1167-75. PubMed ID: 15917100
    [Abstract] [Full Text] [Related]

  • 12. Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein.
    Na CH, Jeon SH, Zhang G, Olson GL, Chae CB.
    J Neurochem; 2007 Jun 14; 101(6):1583-95. PubMed ID: 17542811
    [Abstract] [Full Text] [Related]

  • 13. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
    Ohno M, Chang L, Tseng W, Oakley H, Citron M, Klein WL, Vassar R, Disterhoft JF.
    Eur J Neurosci; 2006 Jan 14; 23(1):251-60. PubMed ID: 16420434
    [Abstract] [Full Text] [Related]

  • 14. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
    Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.
    Neurobiol Dis; 2007 Feb 14; 25(2):291-6. PubMed ID: 17071095
    [Abstract] [Full Text] [Related]

  • 15. BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
    Nishitomi K, Sakaguchi G, Horikoshi Y, Gray AJ, Maeda M, Hirata-Fukae C, Becker AG, Hosono M, Sakaguchi I, Minami SS, Nakajima Y, Li HF, Takeyama C, Kihara T, Ota A, Wong PC, Aisen PS, Kato A, Kinoshita N, Matsuoka Y.
    J Neurochem; 2006 Dec 14; 99(6):1555-63. PubMed ID: 17083447
    [Abstract] [Full Text] [Related]

  • 16. Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor.
    Barten DM, Guss VL, Corsa JA, Loo A, Hansel SB, Zheng M, Munoz B, Srinivasan K, Wang B, Robertson BJ, Polson CT, Wang J, Roberts SB, Hendrick JP, Anderson JJ, Loy JK, Denton R, Verdoorn TA, Smith DW, Felsenstein KM.
    J Pharmacol Exp Ther; 2005 Feb 14; 312(2):635-43. PubMed ID: 15452193
    [Abstract] [Full Text] [Related]

  • 17. Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease.
    He J, Luo H, Yan B, Yu Y, Wang H, Wei Z, Zhang Y, Xu H, Tempier A, Li X, Li XM.
    Neurobiol Aging; 2009 Aug 14; 30(8):1205-16. PubMed ID: 18079026
    [Abstract] [Full Text] [Related]

  • 18. Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing.
    Marcade M, Bourdin J, Loiseau N, Peillon H, Rayer A, Drouin D, Schweighoffer F, Désiré L.
    J Neurochem; 2008 Jul 14; 106(1):392-404. PubMed ID: 18397369
    [Abstract] [Full Text] [Related]

  • 19. Imipramine, in part through tumor necrosis factor alpha inhibition, prevents cognitive decline and beta-amyloid accumulation in a mouse model of Alzheimer's disease.
    Chavant F, Deguil J, Pain S, Ingrand I, Milin S, Fauconneau B, Pérault-Pochat MC, Lafay-Chebassier C.
    J Pharmacol Exp Ther; 2010 Feb 14; 332(2):505-14. PubMed ID: 19889791
    [Abstract] [Full Text] [Related]

  • 20. Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently.
    Fu H, Dou J, Li W, Cui W, Mak S, Hu Q, Luo J, Lam CS, Pang Y, Youdim MB, Han Y.
    Eur J Pharmacol; 2009 Nov 25; 623(1-3):14-21. PubMed ID: 19765582
    [Abstract] [Full Text] [Related]

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