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Journal Abstract Search


624 related items for PubMed ID: 17560791

  • 1. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
    Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H.
    Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
    [Abstract] [Full Text] [Related]

  • 2. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J, Ayral E, Hernandez JF, Martinez J, Checler F.
    J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
    [Abstract] [Full Text] [Related]

  • 3. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
    Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A.
    Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
    [Abstract] [Full Text] [Related]

  • 4. The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.
    Laudon H, Winblad B, Näslund J.
    Physiol Behav; 2007 Sep 10; 92(1-2):115-20. PubMed ID: 17588625
    [Abstract] [Full Text] [Related]

  • 5. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.
    J Neurochem; 2005 Sep 10; 94(5):1189-201. PubMed ID: 15992373
    [Abstract] [Full Text] [Related]

  • 6. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
    Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.
    Neurobiol Dis; 2007 Feb 10; 25(2):291-6. PubMed ID: 17071095
    [Abstract] [Full Text] [Related]

  • 7. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
    Frånberg J, Svensson AI, Winblad B, Karlström H, Frykman S.
    Biochem Biophys Res Commun; 2011 Jan 07; 404(1):564-8. PubMed ID: 21146496
    [Abstract] [Full Text] [Related]

  • 8. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S, Zhou H, Walian PJ, Jap BK.
    Proc Natl Acad Sci U S A; 2005 May 24; 102(21):7499-504. PubMed ID: 15890777
    [Abstract] [Full Text] [Related]

  • 9. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
    Shirotani K, Edbauer D, Kostka M, Steiner H, Haass C.
    J Neurochem; 2004 Jun 24; 89(6):1520-7. PubMed ID: 15189355
    [Abstract] [Full Text] [Related]

  • 10. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.
    J Neurosci Res; 2003 Nov 01; 74(3):386-92. PubMed ID: 14598315
    [Abstract] [Full Text] [Related]

  • 11. Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.
    Winkler E, Hobson S, Fukumori A, Dümpelfeld B, Luebbers T, Baumann K, Haass C, Hopf C, Steiner H.
    Biochemistry; 2009 Feb 17; 48(6):1183-97. PubMed ID: 19159235
    [Abstract] [Full Text] [Related]

  • 12. Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.
    Kumar VB, Franko M, Banks WA, Kasinadhuni P, Farr SA, Vyas K, Choudhuri V, Morley JE.
    J Exp Biol; 2009 Feb 17; 212(Pt 4):494-8. PubMed ID: 19181896
    [Abstract] [Full Text] [Related]

  • 13. Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage.
    Pérez-Revuelta BI, Fukumori A, Lammich S, Yamasaki A, Haass C, Steiner H.
    J Neurochem; 2010 Feb 17; 112(4):940-50. PubMed ID: 20021564
    [Abstract] [Full Text] [Related]

  • 14. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.
    J Neurochem; 2006 Feb 17; 96(3):732-42. PubMed ID: 16405513
    [Abstract] [Full Text] [Related]

  • 15. p53 is regulated by and regulates members of the gamma-secretase complex.
    Checler F, Dunys J, Pardossi-Piquard R, Alves da Costa C.
    Neurodegener Dis; 2010 Feb 17; 7(1-3):50-5. PubMed ID: 20160459
    [Abstract] [Full Text] [Related]

  • 16. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
    Shiraishi H, Sai X, Wang HQ, Maeda Y, Kurono Y, Nishimura M, Yanagisawa K, Komano H.
    J Neurochem; 2004 Sep 17; 90(6):1402-13. PubMed ID: 15341524
    [Abstract] [Full Text] [Related]

  • 17. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
    Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ.
    Nature; 2000 Jun 08; 405(6787):689-94. PubMed ID: 10864326
    [Abstract] [Full Text] [Related]

  • 18. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
    Strömberg K, Hansson EM, Laudon H, Bergstedt S, Näslund J, Lundkvist J, Lendahl U.
    J Neurochem; 2005 Nov 08; 95(3):880-90. PubMed ID: 16135086
    [Abstract] [Full Text] [Related]

  • 19. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES, Martinez M, Brunkan AL, Goate A.
    J Neurochem; 2005 Jan 08; 92(2):294-301. PubMed ID: 15663477
    [Abstract] [Full Text] [Related]

  • 20. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N.
    Neurobiol Dis; 2005 Nov 08; 20(2):625-37. PubMed ID: 15936948
    [Abstract] [Full Text] [Related]


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