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Journal Abstract Search

201 related items for PubMed ID: 17576789

  • 1. Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites.
    Ekins S, Chang C, Mani S, Krasowski MD, Reschly EJ, Iyer M, Kholodovych V, Ai N, Welsh WJ, Sinz M, Swaan PW, Patel R, Bachmann K.
    Mol Pharmacol; 2007 Sep; 72(3):592-603. PubMed ID: 17576789
    [Abstract] [Full Text] [Related]

  • 2. Computational discovery of novel low micromolar human pregnane X receptor antagonists.
    Ekins S, Kholodovych V, Ai N, Sinz M, Gal J, Gera L, Welsh WJ, Bachmann K, Mani S.
    Mol Pharmacol; 2008 Sep; 74(3):662-72. PubMed ID: 18579710
    [Abstract] [Full Text] [Related]

  • 3. Evaluation of in vitro PXR-based assays and in silico modeling approaches for understanding the binding of a structurally diverse set of drugs to PXR.
    Xiao L, Nickbarg E, Wang W, Thomas A, Ziebell M, Prosise WW, Lesburg CA, Taremi SS, Gerlach VL, Le HV, Cheng KC.
    Biochem Pharmacol; 2011 Mar 01; 81(5):669-79. PubMed ID: 21145880
    [Abstract] [Full Text] [Related]

  • 4. Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane X receptor antagonists.
    Hodnik Ž, Peterlin Mašič L, Tomašić T, Smodiš D, D'Amore C, Fiorucci S, Kikelj D.
    J Med Chem; 2014 Jun 12; 57(11):4819-33. PubMed ID: 24828006
    [Abstract] [Full Text] [Related]

  • 5. Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently.
    Lille-Langøy R, Goldstone JV, Rusten M, Milnes MR, Male R, Stegeman JJ, Blumberg B, Goksøyr A.
    Toxicol Appl Pharmacol; 2015 Apr 01; 284(1):54-64. PubMed ID: 25680588
    [Abstract] [Full Text] [Related]

  • 6. Ligand- and structure-based pregnane X receptor models.
    Kortagere S, Krasowski MD, Ekins S.
    Methods Mol Biol; 2012 Apr 01; 929():359-75. PubMed ID: 23007437
    [Abstract] [Full Text] [Related]

  • 7. Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR.
    Li H, Redinbo MR, Venkatesh M, Ekins S, Chaudhry A, Bloch N, Negassa A, Mukherjee P, Kalpana G, Mani S.
    J Biol Chem; 2013 May 10; 288(19):13655-68. PubMed ID: 23525103
    [Abstract] [Full Text] [Related]

  • 8. A pharmacophore for human pregnane X receptor ligands.
    Ekins S, Erickson JA.
    Drug Metab Dispos; 2002 Jan 10; 30(1):96-9. PubMed ID: 11744617
    [Abstract] [Full Text] [Related]

  • 9. Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor.
    Banerjee M, Chen T.
    Biochem Pharmacol; 2013 Sep 15; 86(6):824-35. PubMed ID: 23928187
    [Abstract] [Full Text] [Related]

  • 10. Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor.
    Watkins RE, Davis-Searles PR, Lambert MH, Redinbo MR.
    J Mol Biol; 2003 Aug 22; 331(4):815-28. PubMed ID: 12909012
    [Abstract] [Full Text] [Related]

  • 11. The identification of ligand features essential for PXR activation by pharmacophore modeling.
    Schuster D, Langer T.
    J Chem Inf Model; 2005 Aug 22; 45(2):431-9. PubMed ID: 15807509
    [Abstract] [Full Text] [Related]

  • 12. Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR.
    Ekins S, Kortagere S, Iyer M, Reschly EJ, Lill MA, Redinbo MR, Krasowski MD.
    PLoS Comput Biol; 2009 Dec 22; 5(12):e1000594. PubMed ID: 20011107
    [Abstract] [Full Text] [Related]

  • 13. Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity.
    Pasquel D, Doricakova A, Li H, Kortagere S, Krasowski MD, Biswas A, Walton WG, Redinbo MR, Dvorak Z, Mani S.
    Biochim Biophys Acta; 2016 Sep 22; 1859(9):1155-1169. PubMed ID: 26855179
    [Abstract] [Full Text] [Related]

  • 14. Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism.
    Xue Y, Chao E, Zuercher WJ, Willson TM, Collins JL, Redinbo MR.
    Bioorg Med Chem; 2007 Mar 01; 15(5):2156-66. PubMed ID: 17215127
    [Abstract] [Full Text] [Related]

  • 15. PXR antagonists and implication in drug metabolism.
    Mani S, Dou W, Redinbo MR.
    Drug Metab Rev; 2013 Feb 01; 45(1):60-72. PubMed ID: 23330542
    [Abstract] [Full Text] [Related]

  • 16. The structural basis of pregnane X receptor binding promiscuity.
    Ngan CH, Beglov D, Rudnitskaya AN, Kozakov D, Waxman DJ, Vajda S.
    Biochemistry; 2009 Dec 08; 48(48):11572-81. PubMed ID: 19856963
    [Abstract] [Full Text] [Related]

  • 17. 4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity.
    De Marino S, Ummarino R, D'Auria MV, Chini MG, Bifulco G, D'Amore C, Renga B, Mencarelli A, Petek S, Fiorucci S, Zampella A.
    Steroids; 2012 Apr 08; 77(5):484-95. PubMed ID: 22285937
    [Abstract] [Full Text] [Related]

  • 18. Dietary phytochemicals as modulators of human pregnane X receptor.
    Zhang J, Pavek P, Kamaraj R, Ren L, Zhang T.
    Crit Rev Food Sci Nutr; 2023 Apr 08; 63(19):3279-3301. PubMed ID: 34698593
    [Abstract] [Full Text] [Related]

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  • 20. Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721.
    Cheng Y, Redinbo MR.
    Protein Sci; 2011 Oct 08; 20(10):1713-9. PubMed ID: 21805522
    [Abstract] [Full Text] [Related]

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