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528 related items for PubMed ID: 17576841

  • 1. Roles of P-glycoprotein, Bcrp, and Mrp2 in biliary excretion of spiramycin in mice.
    Tian X, Li J, Zamek-Gliszczynski MJ, Bridges AS, Zhang P, Patel NJ, Raub TJ, Pollack GM, Brouwer KL.
    Antimicrob Agents Chemother; 2007 Sep; 51(9):3230-4. PubMed ID: 17576841
    [Abstract] [Full Text] [Related]

  • 2. Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1.
    Zamek-Gliszczynski MJ, Hoffmaster KA, Tian X, Zhao R, Polli JW, Humphreys JE, Webster LO, Bridges AS, Kalvass JC, Brouwer KL.
    Drug Metab Dispos; 2005 Aug; 33(8):1158-65. PubMed ID: 15860656
    [Abstract] [Full Text] [Related]

  • 3. Altered hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice.
    Nezasa K, Tian X, Zamek-Gliszczynski MJ, Patel NJ, Raub TJ, Brouwer KL.
    Drug Metab Dispos; 2006 Apr; 34(4):718-23. PubMed ID: 16434545
    [Abstract] [Full Text] [Related]

  • 4. Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice.
    Tian X, Zamek-Gliszczynski MJ, Li J, Bridges AS, Nezasa K, Patel NJ, Raub TJ, Brouwer KL.
    Drug Metab Dispos; 2008 Jan; 36(1):61-4. PubMed ID: 17913796
    [Abstract] [Full Text] [Related]

  • 5. Hepatobiliary disposition of 3alpha,6alpha,7alpha,12alpha-tetrahydroxy-cholanoyl taurine: a substrate for multiple canalicular transporters.
    Megaraj V, Iida T, Jungsuwadee P, Hofmann AF, Vore M.
    Drug Metab Dispos; 2010 Oct; 38(10):1723-30. PubMed ID: 20643783
    [Abstract] [Full Text] [Related]

  • 6. Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.
    Vlaming ML, Teunissen SF, van de Steeg E, van Esch A, Wagenaar E, Brunsveld L, de Greef TF, Rosing H, Schellens JH, Beijnen JH, Schinkel AH.
    Mol Pharmacol; 2014 Mar; 85(3):520-30. PubMed ID: 24334255
    [Abstract] [Full Text] [Related]

  • 7. Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat.
    Zamek-Gliszczynski MJ, Hoffmaster KA, Humphreys JE, Tian X, Nezasa K, Brouwer KL.
    J Pharmacol Exp Ther; 2006 Oct; 319(1):459-67. PubMed ID: 16857726
    [Abstract] [Full Text] [Related]

  • 8. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.
    Zamek-Gliszczynski MJ, Bedwell DW, Bao JQ, Higgins JW.
    Drug Metab Dispos; 2012 Sep; 40(9):1825-33. PubMed ID: 22711747
    [Abstract] [Full Text] [Related]

  • 9. Zinc finger nuclease-mediated gene knockout results in loss of transport activity for P-glycoprotein, BCRP, and MRP2 in Caco-2 cells.
    Sampson KE, Brinker A, Pratt J, Venkatraman N, Xiao Y, Blasberg J, Steiner T, Bourner M, Thompson DC.
    Drug Metab Dispos; 2015 Feb; 43(2):199-207. PubMed ID: 25388687
    [Abstract] [Full Text] [Related]

  • 10. Role of transporters in the disposition of the selective phosphodiesterase-4 inhibitor (+)-2-[4-({[2-(benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid in rat and human.
    Kalgutkar AS, Feng B, Nguyen HT, Frederick KS, Campbell SD, Hatch HL, Bi YA, Kazolias DC, Davidson RE, Mireles RJ, Duignan DB, Choo EF, Zhao SX.
    Drug Metab Dispos; 2007 Nov; 35(11):2111-8. PubMed ID: 17686907
    [Abstract] [Full Text] [Related]

  • 11. Involvement of breast cancer resistance protein (ABCG2) in the biliary excretion mechanism of fluoroquinolones.
    Ando T, Kusuhara H, Merino G, Alvarez AI, Schinkel AH, Sugiyama Y.
    Drug Metab Dispos; 2007 Oct; 35(10):1873-9. PubMed ID: 17639028
    [Abstract] [Full Text] [Related]

  • 12. Hepatobiliary disposition of the metabolically stable opioid peptide [D-Pen2, D-Pen5]-enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems.
    Hoffmaster KA, Zamek-Gliszczynski MJ, Pollack GM, Brouwer KL.
    J Pharmacol Exp Ther; 2004 Dec; 311(3):1203-10. PubMed ID: 15302892
    [Abstract] [Full Text] [Related]

  • 13. Quantitative expression profile of hepatobiliary transporters in sandwich cultured rat and human hepatocytes.
    Li N, Bi YA, Duignan DB, Lai Y.
    Mol Pharm; 2009 Dec; 6(4):1180-9. PubMed ID: 19545175
    [Abstract] [Full Text] [Related]

  • 14. Minor compensatory changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats do not detract from their utility in the study of transporter-mediated pharmacokinetics.
    Zamek-Gliszczynski MJ, Goldstein KM, Paulman A, Baker TK, Ryan TP.
    Drug Metab Dispos; 2013 Jun; 41(6):1174-8. PubMed ID: 23569176
    [Abstract] [Full Text] [Related]

  • 15. Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor.
    Yamada A, Maeda K, Kamiyama E, Sugiyama D, Kondo T, Shiroyanagi Y, Nakazawa H, Okano T, Adachi M, Schuetz JD, Adachi Y, Hu Z, Kusuhara H, Sugiyama Y.
    Drug Metab Dispos; 2007 Dec; 35(12):2166-76. PubMed ID: 17823233
    [Abstract] [Full Text] [Related]

  • 16. Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of beta-lactam antibiotics.
    Kato Y, Takahara S, Kato S, Kubo Y, Sai Y, Tamai I, Yabuuchi H, Tsuji A.
    Drug Metab Dispos; 2008 Jun; 36(6):1088-96. PubMed ID: 18339814
    [Abstract] [Full Text] [Related]

  • 17. Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions.
    Breedveld P, Zelcer N, Pluim D, Sönmezer O, Tibben MM, Beijnen JH, Schinkel AH, van Tellingen O, Borst P, Schellens JH.
    Cancer Res; 2004 Aug 15; 64(16):5804-11. PubMed ID: 15313923
    [Abstract] [Full Text] [Related]

  • 18. The important role of Bcrp (Abcg2) in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in mice.
    Zamek-Gliszczynski MJ, Nezasa K, Tian X, Kalvass JC, Patel NJ, Raub TJ, Brouwer KL.
    Mol Pharmacol; 2006 Dec 15; 70(6):2127-33. PubMed ID: 16959944
    [Abstract] [Full Text] [Related]

  • 19. Altered hepatobiliary disposition of acetaminophen glucuronide in isolated perfused livers from multidrug resistance-associated protein 2-deficient TR(-) rats.
    Xiong H, Turner KC, Ward ES, Jansen PL, Brouwer KL.
    J Pharmacol Exp Ther; 2000 Nov 15; 295(2):512-8. PubMed ID: 11046083
    [Abstract] [Full Text] [Related]

  • 20. Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver.
    Lee JK, Abe K, Bridges AS, Patel NJ, Raub TJ, Pollack GM, Brouwer KL.
    Drug Metab Dispos; 2009 Sep 15; 37(9):1916-21. PubMed ID: 19487254
    [Abstract] [Full Text] [Related]

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