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303 related items for PubMed ID: 17579185

  • 1. A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove.
    Percy MJ, Furlow PW, Beer PA, Lappin TR, McMullin MF, Lee FS.
    Blood; 2007 Sep 15; 110(6):2193-6. PubMed ID: 17579185
    [Abstract] [Full Text] [Related]

  • 2. Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis.
    Semenza GL.
    Blood; 2009 Sep 03; 114(10):2015-9. PubMed ID: 19494350
    [Abstract] [Full Text] [Related]

  • 3. The HIF pathway and erythrocytosis.
    Lee FS, Percy MJ.
    Annu Rev Pathol; 2011 Sep 03; 6():165-92. PubMed ID: 20939709
    [Abstract] [Full Text] [Related]

  • 4. Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline.
    Furlow PW, Percy MJ, Sutherland S, Bierl C, McMullin MF, Master SR, Lappin TR, Lee FS.
    J Biol Chem; 2009 Apr 03; 284(14):9050-8. PubMed ID: 19208626
    [Abstract] [Full Text] [Related]

  • 5. Oxygen sensing: recent insights from idiopathic erythrocytosis.
    Lee FS, Percy MJ, McMullin MF.
    Cell Cycle; 2006 May 03; 5(9):941-5. PubMed ID: 16687917
    [Abstract] [Full Text] [Related]

  • 6. Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia.
    Ladroue C, Hoogewijs D, Gad S, Carcenac R, Storti F, Barrois M, Gimenez-Roqueplo AP, Leporrier M, Casadevall N, Hermine O, Kiladjian JJ, Baruchel A, Fakhoury F, Bressac-de Paillerets B, Feunteun J, Mazure N, Pouysségur J, Wenger RH, Richard S, Gardie B.
    Haematologica; 2012 Jan 03; 97(1):9-14. PubMed ID: 21933857
    [Abstract] [Full Text] [Related]

  • 7. Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition.
    Chintala S, Najrana T, Toth K, Cao S, Durrani FA, Pili R, Rustum YM.
    BMC Cancer; 2012 Jul 17; 12():293. PubMed ID: 22804960
    [Abstract] [Full Text] [Related]

  • 8. Disturbance in the HIF-1alpha pathway associated with erythrocytosis: further evidences brought by frameshift and nonsense mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene.
    Al-Sheikh M, Moradkhani K, Lopez M, Wajcman H, Préhu C.
    Blood Cells Mol Dis; 2008 Jul 17; 40(2):160-5. PubMed ID: 17933562
    [Abstract] [Full Text] [Related]

  • 9. A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis.
    Percy MJ, Zhao Q, Flores A, Harrison C, Lappin TR, Maxwell PH, McMullin MF, Lee FS.
    Proc Natl Acad Sci U S A; 2006 Jan 17; 103(3):654-9. PubMed ID: 16407130
    [Abstract] [Full Text] [Related]

  • 10. HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.
    Franke K, Kalucka J, Mamlouk S, Singh RP, Muschter A, Weidemann A, Iyengar V, Jahn S, Wieczorek K, Geiger K, Muders M, Sykes AM, Poitz DM, Ripich T, Otto T, Bergmann S, Breier G, Baretton G, Fong GH, Greaves DR, Bornstein S, Chavakis T, Fandrey J, Gassmann M, Wielockx B.
    Blood; 2013 Feb 21; 121(8):1436-45. PubMed ID: 23264599
    [Abstract] [Full Text] [Related]

  • 11. Update on mutations in the HIF: EPO pathway and their role in erythrocytosis.
    Lappin TR, Lee FS.
    Blood Rev; 2019 Sep 21; 37():100590. PubMed ID: 31350093
    [Abstract] [Full Text] [Related]

  • 12. Src activates HIF-1α not through direct phosphorylation of HIF-1α specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway.
    Lee HY, Lee T, Lee N, Yang EG, Lee C, Lee J, Moon EY, Ha J, Park H.
    Carcinogenesis; 2011 May 21; 32(5):703-12. PubMed ID: 21335603
    [Abstract] [Full Text] [Related]

  • 13. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.
    Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E.
    Biochem J; 2004 Aug 01; 381(Pt 3):761-7. PubMed ID: 15104534
    [Abstract] [Full Text] [Related]

  • 14. The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-α.
    Song D, Peng K, Palmer BE, Lee FS.
    EMBO J; 2022 Nov 17; 41(22):e112059. PubMed ID: 36219563
    [Abstract] [Full Text] [Related]

  • 15. Role of the intracellular localization of HIF-prolyl hydroxylases.
    Yasumoto K, Kowata Y, Yoshida A, Torii S, Sogawa K.
    Biochim Biophys Acta; 2009 May 17; 1793(5):792-7. PubMed ID: 19339211
    [Abstract] [Full Text] [Related]

  • 16. Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors.
    Aprelikova O, Chandramouli GV, Wood M, Vasselli JR, Riss J, Maranchie JK, Linehan WM, Barrett JC.
    J Cell Biochem; 2004 Jun 01; 92(3):491-501. PubMed ID: 15156561
    [Abstract] [Full Text] [Related]

  • 17. A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.
    Minamishima YA, Moslehi J, Padera RF, Bronson RT, Liao R, Kaelin WG.
    Mol Cell Biol; 2009 Nov 01; 29(21):5729-41. PubMed ID: 19720742
    [Abstract] [Full Text] [Related]

  • 18. Isolated Erythrocytosis Associated With 3 Novel Missense Mutations in the EGLN1 Gene.
    Moore JA, Hubbi ME, Wang C, Wang Y, Luo W, Hofmann S, Rambally S.
    J Investig Med High Impact Case Rep; 2020 Nov 01; 8():2324709620947256. PubMed ID: 32755251
    [Abstract] [Full Text] [Related]

  • 19. A study of 36 unrelated cases with pure erythrocytosis revealed three new mutations in the erythropoietin receptor gene.
    Al-Sheikh M, Mazurier E, Gardie B, Casadevall N, Galactéros F, Goossens M, Wajcman H, Préhu C, Ugo V.
    Haematologica; 2008 Jul 01; 93(7):1072-5. PubMed ID: 18492694
    [Abstract] [Full Text] [Related]

  • 20. PHD2 mutation and congenital erythrocytosis with paraganglioma.
    Ladroue C, Carcenac R, Leporrier M, Gad S, Le Hello C, Galateau-Salle F, Feunteun J, Pouysségur J, Richard S, Gardie B.
    N Engl J Med; 2008 Dec 18; 359(25):2685-92. PubMed ID: 19092153
    [Abstract] [Full Text] [Related]

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