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542 related items for PubMed ID: 17596845

  • 1. Definition of an electrostatic relay switch critical for the cAMP-dependent activation of protein kinase A as revealed by the D170A mutant of RIalpha.
    Abu-Abed M, Das R, Wang L, Melacini G.
    Proteins; 2007 Oct 01; 69(1):112-24. PubMed ID: 17596845
    [Abstract] [Full Text] [Related]

  • 2. Crystal structures of RIalpha subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase complexed with (Rp)-adenosine 3',5'-cyclic monophosphothioate and (Sp)-adenosine 3',5'-cyclic monophosphothioate, the phosphothioate analogues of cAMP.
    Wu J, Jones JM, Nguyen-Huu X, Ten Eyck LF, Taylor SS.
    Biochemistry; 2004 Jun 01; 43(21):6620-9. PubMed ID: 15157095
    [Abstract] [Full Text] [Related]

  • 3. Probing cAMP-dependent protein kinase holoenzyme complexes I alpha and II beta by FT-IR and chemical protein footprinting.
    Yu S, Mei FC, Lee JC, Cheng X.
    Biochemistry; 2004 Feb 24; 43(7):1908-20. PubMed ID: 14967031
    [Abstract] [Full Text] [Related]

  • 4. Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS).
    Hamuro Y, Anand GS, Kim JS, Juliano C, Stranz DD, Taylor SS, Woods VL.
    J Mol Biol; 2004 Jul 23; 340(5):1185-96. PubMed ID: 15236976
    [Abstract] [Full Text] [Related]

  • 5. Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA.
    Kim C, Xuong NH, Taylor SS.
    Science; 2005 Feb 04; 307(5710):690-6. PubMed ID: 15692043
    [Abstract] [Full Text] [Related]

  • 6. Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase.
    Herberg FW, Taylor SS, Dostmann WR.
    Biochemistry; 1996 Mar 05; 35(9):2934-42. PubMed ID: 8608131
    [Abstract] [Full Text] [Related]

  • 7. PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation.
    Kim C, Cheng CY, Saldanha SA, Taylor SS.
    Cell; 2007 Sep 21; 130(6):1032-43. PubMed ID: 17889648
    [Abstract] [Full Text] [Related]

  • 8. Allosteric network of cAMP-dependent protein kinase revealed by mutation of Tyr204 in the P+1 loop.
    Yang J, Garrod SM, Deal MS, Anand GS, Woods VL, Taylor S.
    J Mol Biol; 2005 Feb 11; 346(1):191-201. PubMed ID: 15663937
    [Abstract] [Full Text] [Related]

  • 9. Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα.
    Akimoto M, McNicholl ET, Ramkissoon A, Moleschi K, Taylor SS, Melacini G.
    PLoS Biol; 2015 Feb 11; 13(11):e1002305. PubMed ID: 26618408
    [Abstract] [Full Text] [Related]

  • 10. RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B.
    Wu J, Brown S, Xuong NH, Taylor SS.
    Structure; 2004 Jun 11; 12(6):1057-65. PubMed ID: 15274925
    [Abstract] [Full Text] [Related]

  • 11. Dynamic binding of PKA regulatory subunit RI alpha.
    Gullingsrud J, Kim C, Taylor SS, McCammon JA.
    Structure; 2006 Jan 11; 14(1):141-9. PubMed ID: 16407073
    [Abstract] [Full Text] [Related]

  • 12. cAMP activation of PKA defines an ancient signaling mechanism.
    Das R, Esposito V, Abu-Abed M, Anand GS, Taylor SS, Melacini G.
    Proc Natl Acad Sci U S A; 2007 Jan 02; 104(1):93-8. PubMed ID: 17182741
    [Abstract] [Full Text] [Related]

  • 13. Cyclic-AMP and pseudosubstrate effects on type-I A-kinase regulatory and catalytic subunit binding kinetics.
    Anand G, Taylor SS, Johnson DA.
    Biochemistry; 2007 Aug 14; 46(32):9283-91. PubMed ID: 17658893
    [Abstract] [Full Text] [Related]

  • 14. NMR backbone assignment of a protein kinase catalytic domain by a combination of several approaches: application to the catalytic subunit of cAMP-dependent protein kinase.
    Langer T, Vogtherr M, Elshorst B, Betz M, Schieborr U, Saxena K, Schwalbe H.
    Chembiochem; 2004 Nov 05; 5(11):1508-16. PubMed ID: 15481030
    [Abstract] [Full Text] [Related]

  • 15. Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions.
    Vigil D, Blumenthal DK, Heller WT, Brown S, Canaves JM, Taylor SS, Trewhella J.
    J Mol Biol; 2004 Apr 09; 337(5):1183-94. PubMed ID: 15046986
    [Abstract] [Full Text] [Related]

  • 16. Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.
    Nesterova MV, Cho-Chung YS.
    Clin Cancer Res; 2004 Jul 01; 10(13):4568-77. PubMed ID: 15240549
    [Abstract] [Full Text] [Related]

  • 17. Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase.
    Iyer GH, Garrod S, Woods VL, Taylor SS.
    J Mol Biol; 2005 Sep 02; 351(5):1110-22. PubMed ID: 16054648
    [Abstract] [Full Text] [Related]

  • 18. Effect of metal ions on high-affinity binding of pseudosubstrate inhibitors to PKA.
    Zimmermann B, Schweinsberg S, Drewianka S, Herberg FW.
    Biochem J; 2008 Jul 01; 413(1):93-101. PubMed ID: 18373497
    [Abstract] [Full Text] [Related]

  • 19. Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states.
    Mazhab-Jafari MT, Das R, Fotheringham SA, SilDas S, Chowdhury S, Melacini G.
    J Am Chem Soc; 2007 Nov 21; 129(46):14482-92. PubMed ID: 17973384
    [Abstract] [Full Text] [Related]

  • 20. Novel, isotype-specific sensors for protein kinase A subunit interaction based on bioluminescence resonance energy transfer (BRET).
    Prinz A, Diskar M, Erlbruch A, Herberg FW.
    Cell Signal; 2006 Oct 21; 18(10):1616-25. PubMed ID: 16524697
    [Abstract] [Full Text] [Related]

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