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Journal Abstract Search

138 related items for PubMed ID: 17600143

  • 1. FR258900, a potential anti-hyperglycemic drug, binds at the allosteric site of glycogen phosphorylase.
    Tiraidis C, Alexacou KM, Zographos SE, Leonidas DD, Gimisis T, Oikonomakos NG.
    Protein Sci; 2007 Aug; 16(8):1773-82. PubMed ID: 17600143
    [Abstract] [Full Text] [Related]

  • 2. Synthesis of tartaric acid analogues of FR258900 and their evaluation as glycogen phosphorylase inhibitors.
    Varga G, Docsa T, Gergely P, Juhász L, Somsák L.
    Bioorg Med Chem Lett; 2013 Mar 15; 23(6):1789-92. PubMed ID: 23395662
    [Abstract] [Full Text] [Related]

  • 3. Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs.
    Oikonomakos NG, Kosmopoulou MN, Chrysina ED, Leonidas DD, Kostas ID, Wendt KU, Klabunde T, Defossa E.
    Protein Sci; 2005 Jul 15; 14(7):1760-71. PubMed ID: 15987904
    [Abstract] [Full Text] [Related]

  • 4. Crystallographic binding studies on the allosteric inhibitor glucose-6-phosphate to T state glycogen phosphorylase b.
    Johnson LN, Snape P, Martin JL, Acharya KR, Barford D, Oikonomakos NG.
    J Mol Biol; 1993 Jul 05; 232(1):253-67. PubMed ID: 8331662
    [Abstract] [Full Text] [Related]

  • 5. The 1.76 A resolution crystal structure of glycogen phosphorylase B complexed with glucose, and CP320626, a potential antidiabetic drug.
    Oikonomakos NG, Zographos SE, Skamnaki VT, Archontis G.
    Bioorg Med Chem; 2002 May 05; 10(5):1313-9. PubMed ID: 11886794
    [Abstract] [Full Text] [Related]

  • 6. Identification, synthesis, and characterization of new glycogen phosphorylase inhibitors binding to the allosteric AMP site.
    Kristiansen M, Andersen B, Iversen LF, Westergaard N.
    J Med Chem; 2004 Jul 01; 47(14):3537-45. PubMed ID: 15214781
    [Abstract] [Full Text] [Related]

  • 7. The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor.
    Zographos SE, Oikonomakos NG, Tsitsanou KE, Leonidas DD, Chrysina ED, Skamnaki VT, Bischoff H, Goldmann S, Watson KA, Johnson LN.
    Structure; 1997 Nov 15; 5(11):1413-25. PubMed ID: 9384557
    [Abstract] [Full Text] [Related]

  • 8. Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes.
    Klabunde T, Wendt KU, Kadereit D, Brachvogel V, Burger HJ, Herling AW, Oikonomakos NG, Kosmopoulou MN, Schmoll D, Sarubbi E, von Roedern E, Schönafinger K, Defossa E.
    J Med Chem; 2005 Oct 06; 48(20):6178-93. PubMed ID: 16190745
    [Abstract] [Full Text] [Related]

  • 9. Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution.
    Oikonomakos NG, Chrysina ED, Kosmopoulou MN, Leonidas DD.
    Biochim Biophys Acta; 2003 Apr 11; 1647(1-2):325-32. PubMed ID: 12686153
    [Abstract] [Full Text] [Related]

  • 10. Kinetic analysis and modelling of the allosteric behaviour of liver and muscle glycogen phosphorylases.
    Cuadri-Tomé C, Barón C, Jara-Pérez V, Parody-Morreale A, Martinez JC, Cámara-Artigas A.
    J Mol Recognit; 2006 Apr 11; 19(5):451-7. PubMed ID: 16691548
    [Abstract] [Full Text] [Related]

  • 11. Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: comparison of chrysin and flavopiridol.
    Tsitsanou KE, Hayes JM, Keramioti M, Mamais M, Oikonomakos NG, Kato A, Leonidas DD, Zographos SE.
    Food Chem Toxicol; 2013 Nov 11; 61():14-27. PubMed ID: 23279842
    [Abstract] [Full Text] [Related]

  • 12. Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate.
    Oikonomakos NG, Tsitsanou KE, Zographos SE, Skamnaki VT, Goldmann S, Bischoff H.
    Protein Sci; 1999 Oct 11; 8(10):1930-45. PubMed ID: 10548038
    [Abstract] [Full Text] [Related]

  • 13. Comparison of AMP and NADH binding to glycogen phosphorylase b.
    Stura EA, Zanotti G, Babu YS, Sansom MS, Stuart DI, Wilson KS, Johnson LN, Van de Werve G.
    J Mol Biol; 1983 Oct 25; 170(2):529-65. PubMed ID: 6415289
    [Abstract] [Full Text] [Related]

  • 14. A new allosteric site in glycogen phosphorylase b as a target for drug interactions.
    Oikonomakos NG, Skamnaki VT, Tsitsanou KE, Gavalas NG, Johnson LN.
    Structure; 2000 Jun 15; 8(6):575-84. PubMed ID: 10873856
    [Abstract] [Full Text] [Related]

  • 15. The crystal structure of human muscle glycogen phosphorylase a with bound glucose and AMP: an intermediate conformation with T-state and R-state features.
    Lukacs CM, Oikonomakos NG, Crowther RL, Hong LN, Kammlott RU, Levin W, Li S, Liu CM, Lucas-McGady D, Pietranico S, Reik L.
    Proteins; 2006 Jun 01; 63(4):1123-6. PubMed ID: 16523484
    [No Abstract] [Full Text] [Related]

  • 16. FR258900, a novel glycogen phosphorylase inhibitor isolated from Fungus No. 138354. II. Anti-hyperglycemic effects in diabetic animal models.
    Furukawa S, Murakami K, Nishikawa M, Nakayama O, Hino M.
    J Antibiot (Tokyo); 2005 Aug 01; 58(8):503-6. PubMed ID: 16266121
    [Abstract] [Full Text] [Related]

  • 17. Natural flavonoids as antidiabetic agents. The binding of gallic and ellagic acids to glycogen phosphorylase b.
    Kyriakis E, Stravodimos GA, Kantsadi AL, Chatzileontiadou DS, Skamnaki VT, Leonidas DD.
    FEBS Lett; 2015 Jul 08; 589(15):1787-94. PubMed ID: 25980608
    [Abstract] [Full Text] [Related]

  • 18. Allosteric interactions of glycogen phosphorylase b. A crystallographic study of glucose 6-phosphate and inorganic phosphate binding to di-imidate-cross-linked phosphorylase b.
    Lorek A, Wilson KS, Sansom MS, Stuart DI, Stura EA, Jenkins JA, Zanotti G, Hajdu J, Johnson LN.
    Biochem J; 1984 Feb 15; 218(1):45-60. PubMed ID: 6424657
    [Abstract] [Full Text] [Related]

  • 19. FR258900, a novel glycogen phosphorylase inhibitor isolated from Fungus No. 138354. I. Taxonomy, fermentation, isolation and biological activities.
    Furukawa S, Tsurumi Y, Murakami K, Nakanishi T, Ohsumi K, Hashimoto M, Nishikawa M, Takase S, Nakayama O, Hino M.
    J Antibiot (Tokyo); 2005 Aug 15; 58(8):497-502. PubMed ID: 16266120
    [Abstract] [Full Text] [Related]

  • 20. Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP.
    Barford D, Hu SH, Johnson LN.
    J Mol Biol; 1991 Mar 05; 218(1):233-60. PubMed ID: 1900534
    [Abstract] [Full Text] [Related]

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