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Journal Abstract Search


372 related items for PubMed ID: 17655213

  • 1. 5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.
    Madsen C, Jensen AA, Liljefors T, Kristiansen U, Nielsen B, Hansen CP, Larsen M, Ebert B, Bang-Andersen B, Krogsgaard-Larsen P, Frølund B.
    J Med Chem; 2007 Aug 23; 50(17):4147-61. PubMed ID: 17655213
    [Abstract] [Full Text] [Related]

  • 2. Synthesis, structure-activity relationships at the GABA(A) receptor in rat brain, and differential electrophysiological profile at the recombinant human GABA(A) receptor of a series of substituted 1,2-diphenylimidazoles.
    Asproni B, Talani G, Busonero F, Pau A, Sanna S, Cerri R, Mascia MP, Sanna E, Biggio G.
    J Med Chem; 2005 Apr 07; 48(7):2638-45. PubMed ID: 15801854
    [Abstract] [Full Text] [Related]

  • 3. Analogues of gamma-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists.
    Chebib M, Vandenberg RJ, Johnston GA.
    Br J Pharmacol; 1997 Dec 07; 122(8):1551-60. PubMed ID: 9422798
    [Abstract] [Full Text] [Related]

  • 4. Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality.
    Jacobsen EJ, Stelzer LS, TenBrink RE, Belonga KL, Carter DB, Im HK, Im WB, Sethy VH, Tang AH, VonVoigtlander PF, Petke JD, Zhong WZ, Mickelson JW.
    J Med Chem; 1999 Apr 08; 42(7):1123-44. PubMed ID: 10197957
    [Abstract] [Full Text] [Related]

  • 5. trans-4-Amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA(C) receptors.
    Vien J, Duke RK, Mewett KN, Johnston GA, Shingai R, Chebib M.
    Br J Pharmacol; 2002 Feb 08; 135(4):883-90. PubMed ID: 11861315
    [Abstract] [Full Text] [Related]

  • 6. Pharmacology of GABAC receptors: responses to agonists and antagonists distinguish A- and B-subtypes of homomeric rho receptors expressed in Xenopus oocytes.
    Pan Y, Khalili P, Ripps H, Qian H.
    Neurosci Lett; 2005 Mar 07; 376(1):60-5. PubMed ID: 15694275
    [Abstract] [Full Text] [Related]

  • 7. Mutations of the 2' proline in the M2 domain of the human GABAC rho1 subunit alter agonist responses.
    Carland JE, Moore AM, Hanrahan JR, Mewett KN, Duke RK, Johnston GA, Chebib M.
    Neuropharmacology; 2004 May 07; 46(6):770-81. PubMed ID: 15033337
    [Abstract] [Full Text] [Related]

  • 8. Neurosteroid modulation of recombinant rat alpha5beta2gamma2L and alpha1beta2gamma2L GABA(A) receptors in Xenopus oocyte.
    Rahman M, Lindblad C, Johansson IM, Bäckström T, Wang MD.
    Eur J Pharmacol; 2006 Oct 10; 547(1-3):37-44. PubMed ID: 16934248
    [Abstract] [Full Text] [Related]

  • 9. Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.
    Chambers MS, Atack JR, Broughton HB, Collinson N, Cook S, Dawson GR, Hobbs SC, Marshall G, Maubach KA, Pillai GV, Reeve AJ, MacLeod AM.
    J Med Chem; 2003 May 22; 46(11):2227-40. PubMed ID: 12747794
    [Abstract] [Full Text] [Related]

  • 10. Identification of a domain in the delta subunit (S238-V264) of the alpha4beta3delta GABAA receptor that confers high agonist sensitivity.
    You H, Dunn SM.
    J Neurochem; 2007 Nov 22; 103(3):1092-101. PubMed ID: 17711419
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors.
    Cox ED, Diaz-Arauzo H, Huang Q, Reddy MS, Ma C, Harris B, McKernan R, Skolnick P, Cook JM.
    J Med Chem; 1998 Jul 02; 41(14):2537-52. PubMed ID: 9651158
    [Abstract] [Full Text] [Related]

  • 12. Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ1 γ-Aminobutyric Acid Type A Receptor Antagonists with Effect on Retinal Vascular Tone.
    Krall J, Brygger BM, Sigurðardóttir SB, Ng CK, Bundgaard C, Kehler J, Nielsen B, Bek T, Jensen AA, Frølund B.
    ChemMedChem; 2016 Oct 19; 11(20):2299-2310. PubMed ID: 27620323
    [Abstract] [Full Text] [Related]

  • 13. Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA A receptor agonists at the alpha3 subunit.
    Russell MG, Carling RW, Atack JR, Bromidge FA, Cook SM, Hunt P, Isted C, Lucas M, McKernan RM, Mitchinson A, Moore KW, Narquizian R, Macaulay AJ, Thomas D, Thompson SA, Wafford KA, Castro JL.
    J Med Chem; 2005 Mar 10; 48(5):1367-83. PubMed ID: 15743180
    [Abstract] [Full Text] [Related]

  • 14. Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.
    Krehan D, Storustovu SI, Liljefors T, Ebert B, Nielsen B, Krogsgaard-Larsen P, Frølund B.
    J Med Chem; 2006 Feb 23; 49(4):1388-96. PubMed ID: 16480274
    [Abstract] [Full Text] [Related]

  • 15. Pharmacological characterization of agonists at delta-containing GABAA receptors: Functional selectivity for extrasynaptic receptors is dependent on the absence of gamma2.
    Stórustovu SI, Ebert B.
    J Pharmacol Exp Ther; 2006 Mar 23; 316(3):1351-9. PubMed ID: 16272218
    [Abstract] [Full Text] [Related]

  • 16. 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels.
    Husain SS, Ziebell MR, Ruesch D, Hong F, Arevalo E, Kosterlitz JA, Olsen RW, Forman SA, Cohen JB, Miller KW.
    J Med Chem; 2003 Mar 27; 46(7):1257-65. PubMed ID: 12646036
    [Abstract] [Full Text] [Related]

  • 17. Structural determinants for antagonist pharmacology that distinguish the rho1 GABAC receptor from GABAA receptors.
    Zhang J, Xue F, Chang Y.
    Mol Pharmacol; 2008 Oct 27; 74(4):941-51. PubMed ID: 18599601
    [Abstract] [Full Text] [Related]

  • 18. 6,2'-Dihydroxyflavone, a subtype-selective partial inverse agonist of GABAA receptor benzodiazepine site.
    Wang F, Xu Z, Yuen CT, Chow CY, Lui YL, Tsang SY, Xue H.
    Neuropharmacology; 2007 Sep 27; 53(4):574-82. PubMed ID: 17681556
    [Abstract] [Full Text] [Related]

  • 19. High pH accelerates GABA deactivation on perch-rho1B receptors.
    Qian H, Pan Y, Choi B, Ripps H.
    Neuroscience; 2006 Nov 03; 142(4):1221-30. PubMed ID: 16920274
    [Abstract] [Full Text] [Related]

  • 20. Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes.
    Scaglione JB, Jastrzebska I, Krishnan K, Li P, Akk G, Manion BD, Benz A, Taylor A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF.
    J Med Chem; 2008 Mar 13; 51(5):1309-18. PubMed ID: 18275132
    [Abstract] [Full Text] [Related]


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