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1510 related items for PubMed ID: 17683641

  • 1. Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy.
    Tchetina EV, Di Battista JA, Zukor DJ, Antoniou J, Poole AR.
    Arthritis Res Ther; 2007; 9(4):R75. PubMed ID: 17683641
    [Abstract] [Full Text] [Related]

  • 2. Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.
    Tchetina EV, Squires G, Poole AR.
    J Rheumatol; 2005 May; 32(5):876-86. PubMed ID: 15868625
    [Abstract] [Full Text] [Related]

  • 3. Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) production.
    Tchetina EV, Antoniou J, Tanzer M, Zukor DJ, Poole AR.
    Am J Pathol; 2006 Jan; 168(1):131-40. PubMed ID: 16400016
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  • 5. Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.
    Kobayashi M, Squires GR, Mousa A, Tanzer M, Zukor DJ, Antoniou J, Feige U, Poole AR.
    Arthritis Rheum; 2005 Jan; 52(1):128-35. PubMed ID: 15641080
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  • 6. Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1).
    Dahlberg L, Billinghurst RC, Manner P, Nelson F, Webb G, Ionescu M, Reiner A, Tanzer M, Zukor D, Chen J, van Wart HE, Poole AR.
    Arthritis Rheum; 2000 Mar; 43(3):673-82. PubMed ID: 10728762
    [Abstract] [Full Text] [Related]

  • 7. Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: implications for development and arthritis.
    Tchetina EV, Kobayashi M, Yasuda T, Meijers T, Pidoux I, Poole AR.
    Matrix Biol; 2007 May; 26(4):247-58. PubMed ID: 17306969
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  • 8. Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13.
    Wu W, Billinghurst RC, Pidoux I, Antoniou J, Zukor D, Tanzer M, Poole AR.
    Arthritis Rheum; 2002 Aug; 46(8):2087-94. PubMed ID: 12209513
    [Abstract] [Full Text] [Related]

  • 9. Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes.
    Vonk LA, Kragten AH, Dhert WJ, Saris DB, Creemers LB.
    Osteoarthritis Cartilage; 2014 Jan; 22(1):145-53. PubMed ID: 24269634
    [Abstract] [Full Text] [Related]

  • 10. Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis.
    Appleton CT, Usmani SE, Bernier SM, Aigner T, Beier F.
    Arthritis Rheum; 2007 Nov; 56(11):3693-705. PubMed ID: 17968906
    [Abstract] [Full Text] [Related]

  • 11. Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes.
    Roman-Blas JA, Stokes DG, Jimenez SA.
    Osteoarthritis Cartilage; 2007 Dec; 15(12):1367-77. PubMed ID: 17604656
    [Abstract] [Full Text] [Related]

  • 12. Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes.
    Maneiro E, López-Armada MJ, Fernández-Sueiro JL, Lema B, Galdo F, Blanco FJ.
    J Rheumatol; 2001 Dec; 28(12):2692-9. PubMed ID: 11764219
    [Abstract] [Full Text] [Related]

  • 13. Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9.
    Cucchiarini M, Thurn T, Weimer A, Kohn D, Terwilliger EF, Madry H.
    Arthritis Rheum; 2007 Jan; 56(1):158-67. PubMed ID: 17195218
    [Abstract] [Full Text] [Related]

  • 14. Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase.
    Billinghurst RC, Wu W, Ionescu M, Reiner A, Dahlberg L, Chen J, van Wart H, Poole AR.
    Arthritis Rheum; 2000 Mar; 43(3):664-72. PubMed ID: 10728761
    [Abstract] [Full Text] [Related]

  • 15. Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta.
    Fan Z, Bau B, Yang H, Soeder S, Aigner T.
    Arthritis Rheum; 2005 Jan; 52(1):136-43. PubMed ID: 15641077
    [Abstract] [Full Text] [Related]

  • 16. Efficacy and mechanism of action of KHBJ-9B, a new herbal medicine, and its major compound triterpenoids in human cartilage culture and in a rabbit model of collagenase-induced osteoarthritis.
    Huh JE, Baek YH, Ryu SR, Lee JD, Choi DY, Park DS.
    Int Immunopharmacol; 2009 Feb; 9(2):230-40. PubMed ID: 19100343
    [Abstract] [Full Text] [Related]

  • 17. The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis.
    Squires GR, Okouneff S, Ionescu M, Poole AR.
    Arthritis Rheum; 2003 May; 48(5):1261-70. PubMed ID: 12746899
    [Abstract] [Full Text] [Related]

  • 18. The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes.
    Kim HA, Cho ML, Choi HY, Yoon CS, Jhun JY, Oh HJ, Kim HY.
    Arthritis Rheum; 2006 Jul; 54(7):2152-63. PubMed ID: 16802353
    [Abstract] [Full Text] [Related]

  • 19. Protective effect of atorvastatin in cultured osteoarthritic chondrocytes.
    Simopoulou T, Malizos KN, Poultsides L, Tsezou A.
    J Orthop Res; 2010 Jan; 28(1):110-5. PubMed ID: 19623662
    [Abstract] [Full Text] [Related]

  • 20. A fibronectin fragment induces type II collagen degradation by collagenase through an interleukin-1-mediated pathway.
    Yasuda T, Poole AR.
    Arthritis Rheum; 2002 Jan; 46(1):138-48. PubMed ID: 11817586
    [Abstract] [Full Text] [Related]

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