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783 related items for PubMed ID: 17685585

  • 1. The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.
    Lei X, Zhang S, Bohrer A, Bao S, Song H, Ramanadham S.
    Biochemistry; 2007 Sep 04; 46(35):10170-85. PubMed ID: 17685585
    [Abstract] [Full Text] [Related]

  • 2. Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis.
    Lei X, Zhang S, Bohrer A, Ramanadham S.
    J Biol Chem; 2008 Dec 12; 283(50):34819-32. PubMed ID: 18936091
    [Abstract] [Full Text] [Related]

  • 3. Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells.
    Barbour SE, Nguyen PT, Park M, Emani B, Lei X, Kambalapalli M, Shultz JC, Wijesinghe D, Chalfant CE, Ramanadham S.
    J Biol Chem; 2015 Apr 24; 290(17):11021-31. PubMed ID: 25762722
    [Abstract] [Full Text] [Related]

  • 4. Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta.
    Ramanadham S, Hsu FF, Zhang S, Jin C, Bohrer A, Song H, Bao S, Ma Z, Turk J.
    Biochemistry; 2004 Feb 03; 43(4):918-30. PubMed ID: 14744135
    [Abstract] [Full Text] [Related]

  • 5. Studies of phospholipid metabolism, proliferation, and secretion of stably transfected insulinoma cells that overexpress group VIA phospholipase A2.
    Ma Z, Bohrer A, Wohltmann M, Ramanadham S, Hsu FF, Turk J.
    Lipids; 2001 Jul 03; 36(7):689-700. PubMed ID: 11521967
    [Abstract] [Full Text] [Related]

  • 6. Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis.
    Sauane M, Su ZZ, Dash R, Liu X, Norris JS, Sarkar D, Lee SG, Allegood JC, Dent P, Spiegel S, Fisher PB.
    J Cell Physiol; 2010 Mar 03; 222(3):546-55. PubMed ID: 19937735
    [Abstract] [Full Text] [Related]

  • 7. Alterations in β-Cell Sphingolipid Profile Associated with ER Stress and iPLA2β: Another Contributor to β-Cell Apoptosis in Type 1 Diabetes.
    Ali T, Lei X, Barbour SE, Koizumi A, Chalfant CE, Ramanadham S.
    Molecules; 2021 Oct 21; 26(21):. PubMed ID: 34770770
    [Abstract] [Full Text] [Related]

  • 8. Genetic modulation of islet β-cell iPLA₂β expression provides evidence for its impact on β-cell apoptosis and autophagy.
    Lei X, Bone RN, Ali T, Wohltmann M, Gai Y, Goodwin KJ, Bohrer AE, Turk J, Ramanadham S.
    Islets; 2013 Oct 21; 5(1):29-44. PubMed ID: 23411472
    [Abstract] [Full Text] [Related]

  • 9. Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signaling.
    Song H, Wohltmann M, Tan M, Bao S, Ladenson JH, Turk J.
    J Biol Chem; 2012 Feb 17; 287(8):5528-41. PubMed ID: 22194610
    [Abstract] [Full Text] [Related]

  • 10. Group VIA phospholipase A2 mitigates palmitate-induced β-cell mitochondrial injury and apoptosis.
    Song H, Wohltmann M, Tan M, Ladenson JH, Turk J.
    J Biol Chem; 2014 May 16; 289(20):14194-210. PubMed ID: 24648512
    [Abstract] [Full Text] [Related]

  • 11. Effects of stable suppression of Group VIA phospholipase A2 expression on phospholipid content and composition, insulin secretion, and proliferation of INS-1 insulinoma cells.
    Bao S, Bohrer A, Ramanadham S, Jin W, Zhang S, Turk J.
    J Biol Chem; 2006 Jan 06; 281(1):187-98. PubMed ID: 16286468
    [Abstract] [Full Text] [Related]

  • 12. Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1.
    Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa FR, Ramanadham S.
    J Biol Chem; 2010 Feb 26; 285(9):6693-705. PubMed ID: 20032468
    [Abstract] [Full Text] [Related]

  • 13. Characterization of FKGK18 as inhibitor of group VIA Ca2+-independent phospholipase A2 (iPLA2β): candidate drug for preventing beta-cell apoptosis and diabetes.
    Ali T, Kokotos G, Magrioti V, Bone RN, Mobley JA, Hancock W, Ramanadham S.
    PLoS One; 2013 Feb 26; 8(8):e71748. PubMed ID: 23977134
    [Abstract] [Full Text] [Related]

  • 14. Increase of nuclear ceramide through caspase-3-dependent regulation of the "sphingomyelin cycle" in Fas-induced apoptosis.
    Watanabe M, Kitano T, Kondo T, Yabu T, Taguchi Y, Tashima M, Umehara H, Domae N, Uchiyama T, Okazaki T.
    Cancer Res; 2004 Feb 01; 64(3):1000-7. PubMed ID: 14871831
    [Abstract] [Full Text] [Related]

  • 15. Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway.
    Lee JT, Xu J, Lee JM, Ku G, Han X, Yang DI, Chen S, Hsu CY.
    J Cell Biol; 2004 Jan 05; 164(1):123-31. PubMed ID: 14709545
    [Abstract] [Full Text] [Related]

  • 16. Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling.
    Scarlatti F, Sala G, Somenzi G, Signorelli P, Sacchi N, Ghidoni R.
    FASEB J; 2003 Dec 05; 17(15):2339-41. PubMed ID: 14563682
    [Abstract] [Full Text] [Related]

  • 17. A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β).
    Lei X, Zhang S, Emani B, Barbour SE, Ramanadham S.
    Diabetes Obes Metab; 2010 Oct 05; 12 Suppl 2(0 2):93-8. PubMed ID: 21029305
    [Abstract] [Full Text] [Related]

  • 18. Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2beta.
    Ma Z, Ramanadham S, Wohltmann M, Bohrer A, Hsu FF, Turk J.
    J Biol Chem; 2001 Apr 20; 276(16):13198-208. PubMed ID: 11278673
    [Abstract] [Full Text] [Related]

  • 19. Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin.
    Mansat V, Bettaïeb A, Levade T, Laurent G, Jaffrézou JP.
    FASEB J; 1997 Jul 20; 11(8):695-702. PubMed ID: 9240970
    [Abstract] [Full Text] [Related]

  • 20. Synovial fibroblasts and the sphingomyelinase pathway: sphingomyelin turnover and ceramide generation are not signaling mechanisms for the actions of tumor necrosis factor-alpha.
    Gerritsen ME, Shen CP, Perry CA.
    Am J Pathol; 1998 Feb 20; 152(2):505-12. PubMed ID: 9466577
    [Abstract] [Full Text] [Related]

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