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305 related items for PubMed ID: 17701470

  • 1. In vivo stabilization of mutant human transthyretin in transgenic mice.
    Tagoe CE, Reixach N, Friske L, Mustra D, French D, Gallo G, Buxbaum JN.
    Amyloid; 2007 Sep; 14(3):227-36. PubMed ID: 17701470
    [Abstract] [Full Text] [Related]

  • 2. Cys-10 mixed disulfide modifications exacerbate transthyretin familial variant amyloidogenicity: a likely explanation for variable clinical expression of amyloidosis and the lack of pathology in C10S/V30M transgenic mice?
    Zhang Q, Kelly JW.
    Biochemistry; 2005 Jun 28; 44(25):9079-85. PubMed ID: 15966731
    [Abstract] [Full Text] [Related]

  • 3. Inconsistency between hepatic expression and serum concentration of transthyretin in mice humanized at the transthyretin locus.
    Zhao G, Li Z, Araki K, Haruna K, Yamaguchi K, Araki M, Takeya M, Ando Y, Yamamura K.
    Genes Cells; 2008 Dec 28; 13(12):1257-68. PubMed ID: 19032346
    [Abstract] [Full Text] [Related]

  • 4. Chromium(III) ion and thyroxine cooperate to stabilize the transthyretin tetramer and suppress in vitro amyloid fibril formation.
    Sato T, Ando Y, Susuki S, Mikami F, Ikemizu S, Nakamura M, Suhr O, Anraku M, Kai T, Suico MA, Shuto T, Mizuguchi M, Yamagata Y, Kai H.
    FEBS Lett; 2006 Jan 23; 580(2):491-6. PubMed ID: 16386248
    [Abstract] [Full Text] [Related]

  • 5. Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis.
    Sekijima Y, Dendle MA, Kelly JW.
    Amyloid; 2006 Dec 23; 13(4):236-49. PubMed ID: 17107884
    [Abstract] [Full Text] [Related]

  • 6. Clusterin regulates transthyretin amyloidosis.
    Lee KW, Lee DH, Son H, Kim YS, Park JY, Roh GS, Kim HJ, Kang SS, Cho GJ, Choi WS.
    Biochem Biophys Res Commun; 2009 Oct 16; 388(2):256-60. PubMed ID: 19664600
    [Abstract] [Full Text] [Related]

  • 7. Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis.
    Foss TR, Kelker MS, Wiseman RL, Wilson IA, Kelly JW.
    J Mol Biol; 2005 Apr 08; 347(4):841-54. PubMed ID: 15769474
    [Abstract] [Full Text] [Related]

  • 8. Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding.
    Trivella DB, Bleicher L, Palmieri Lde C, Wiggers HJ, Montanari CA, Kelly JW, Lima LM, Foguel D, Polikarpov I.
    J Struct Biol; 2010 Jun 08; 170(3):522-31. PubMed ID: 20211733
    [Abstract] [Full Text] [Related]

  • 9. Retention of misfolded mutant transthyretin by the chaperone BiP/GRP78 mitigates amyloidogenesis.
    Sörgjerd K, Ghafouri B, Jonsson BH, Kelly JW, Blond SY, Hammarström P.
    J Mol Biol; 2006 Feb 17; 356(2):469-82. PubMed ID: 16376939
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization.
    Green NS, Palaninathan SK, Sacchettini JC, Kelly JW.
    J Am Chem Soc; 2003 Nov 05; 125(44):13404-14. PubMed ID: 14583036
    [Abstract] [Full Text] [Related]

  • 11. Effect of serum amyloid P component level on transthyretin-derived amyloid deposition in a transgenic mouse model of familial amyloidotic polyneuropathy.
    Murakami T, Yi S, Maeda S, Tashiro F, Yamamura K, Takahashi K, Shimada K, Araki S.
    Am J Pathol; 1992 Aug 05; 141(2):451-6. PubMed ID: 1497094
    [Abstract] [Full Text] [Related]

  • 12. The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin.
    Morais-de-Sá E, Neto-Silva RM, Pereira PJ, Saraiva MJ, Damas AM.
    Acta Crystallogr D Biol Crystallogr; 2006 May 05; 62(Pt 5):512-9. PubMed ID: 16627944
    [Abstract] [Full Text] [Related]

  • 13. Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.
    Hurshman Babbes AR, Powers ET, Kelly JW.
    Biochemistry; 2008 Jul 01; 47(26):6969-84. PubMed ID: 18537267
    [Abstract] [Full Text] [Related]

  • 14. Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis.
    Wiseman RL, Green NS, Kelly JW.
    Biochemistry; 2005 Jun 28; 44(25):9265-74. PubMed ID: 15966751
    [Abstract] [Full Text] [Related]

  • 15. Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice model.
    Cardoso I, Saraiva MJ.
    FASEB J; 2006 Feb 28; 20(2):234-9. PubMed ID: 16449795
    [Abstract] [Full Text] [Related]

  • 16. Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation.
    Lashuel HA, Lai Z, Kelly JW.
    Biochemistry; 1998 Dec 22; 37(51):17851-64. PubMed ID: 9922152
    [Abstract] [Full Text] [Related]

  • 17. Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis.
    Tojo K, Sekijima Y, Kelly JW, Ikeda S.
    Neurosci Res; 2006 Dec 22; 56(4):441-9. PubMed ID: 17028027
    [Abstract] [Full Text] [Related]

  • 18. Change in structure of the N-terminal region of transthyretin produces change in affinity of transthyretin to T4 and T3.
    Prapunpoj P, Leelawatwatana L, Schreiber G, Richardson SJ.
    FEBS J; 2006 Sep 22; 273(17):4013-23. PubMed ID: 16879610
    [Abstract] [Full Text] [Related]

  • 19. A transgenic mouse line developed to express human amyloidogenic transthyretin cDNA in the brain.
    Ohuchi K, Matsuda A, Maeda S, Shimada K, Miyakawa T.
    Biochem Int; 1991 Mar 22; 23(5):809-17. PubMed ID: 1715703
    [Abstract] [Full Text] [Related]

  • 20. Dissecting the structure, thermodynamic stability, and aggregation properties of the A25T transthyretin (A25T-TTR) variant involved in leptomeningeal amyloidosis: identifying protein partners that co-aggregate during A25T-TTR fibrillogenesis in cerebrospinal fluid.
    Azevedo EP, Pereira HM, Garratt RC, Kelly JW, Foguel D, Palhano FL.
    Biochemistry; 2011 Dec 27; 50(51):11070-83. PubMed ID: 22091638
    [Abstract] [Full Text] [Related]

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