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220 related items for PubMed ID: 17717079

  • 1. Analysis of CYP2A contributions to metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human peripheral lung microsomes.
    Brown PJ, Bedard LL, Reid KR, Petsikas D, Massey TE.
    Drug Metab Dispos; 2007 Nov; 35(11):2086-94. PubMed ID: 17717079
    [Abstract] [Full Text] [Related]

  • 2. Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in peripheral human lung microsomes.
    Smith GB, Bend JR, Bedard LL, Reid KR, Petsikas D, Massey TE.
    Drug Metab Dispos; 2003 Sep; 31(9):1134-41. PubMed ID: 12920169
    [Abstract] [Full Text] [Related]

  • 3. CYP2A13: variable expression and role in human lung microsomal metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    Zhang X, D'Agostino J, Wu H, Zhang QY, von Weymarn L, Murphy SE, Ding X.
    J Pharmacol Exp Ther; 2007 Nov; 323(2):570-8. PubMed ID: 17671098
    [Abstract] [Full Text] [Related]

  • 4. Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.
    Jalas JR, Ding X, Murphy SE.
    Drug Metab Dispos; 2003 Oct; 31(10):1199-202. PubMed ID: 12975327
    [Abstract] [Full Text] [Related]

  • 5. Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) iastereomers and metabolism by A/J mouse lung microsomes and cytochrome p450 2A5.
    Jalas JR, Hecht SS.
    Chem Res Toxicol; 2003 Jun; 16(6):782-93. PubMed ID: 12807362
    [Abstract] [Full Text] [Related]

  • 6. Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in lung tissue from mouse, rat, hamster, and man.
    Richter E, Engl J, Friesenegger S, Tricker AR.
    Chem Res Toxicol; 2009 Jun; 22(6):1008-17. PubMed ID: 19408892
    [Abstract] [Full Text] [Related]

  • 7. Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK.
    Wang H, Tan W, Hao B, Miao X, Zhou G, He F, Lin D.
    Cancer Res; 2003 Nov 15; 63(22):8057-61. PubMed ID: 14633739
    [Abstract] [Full Text] [Related]

  • 8. Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.
    Chiang HC, Wang CY, Lee HL, Tsou TC.
    Toxicol Appl Pharmacol; 2011 Jun 01; 253(2):145-52. PubMed ID: 21473878
    [Abstract] [Full Text] [Related]

  • 9. Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes.
    Smith TJ, Liao AM, Liu Y, Jones AB, Anderson LM, Yang CS.
    Carcinogenesis; 1997 Aug 01; 18(8):1577-84. PubMed ID: 9276633
    [Abstract] [Full Text] [Related]

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  • 11. Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.
    Megaraj V, Zhou X, Xie F, Liu Z, Yang W, Ding X.
    Carcinogenesis; 2014 Jan 01; 35(1):131-7. PubMed ID: 23917075
    [Abstract] [Full Text] [Related]

  • 12. Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen.
    He XY, Shen J, Ding X, Lu AY, Hong JY.
    Drug Metab Dispos; 2004 Dec 01; 32(12):1516-21. PubMed ID: 15333516
    [Abstract] [Full Text] [Related]

  • 13. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells.
    Smith TJ, Guo Z, Gonzalez FJ, Guengerich FP, Stoner GD, Yang CS.
    Cancer Res; 1992 Apr 01; 52(7):1757-63. PubMed ID: 1312898
    [Abstract] [Full Text] [Related]

  • 14. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes gene polymorphisms, NNK metabolites levels and urothelial carcinoma.
    Chung CJ, Pu YS, Shiue HS, Lee HL, Lin P, Yang HY, Su CT, Hsueh YM.
    Toxicol Lett; 2013 Jan 10; 216(1):16-22. PubMed ID: 23142425
    [Abstract] [Full Text] [Related]

  • 15. Characterization of cytochrome P450 2A4 and 2A5-catalyzed 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism.
    Felicia ND, Rekha GK, Murphy SE.
    Arch Biochem Biophys; 2000 Dec 15; 384(2):418-24. PubMed ID: 11368333
    [Abstract] [Full Text] [Related]

  • 16. Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    Su T, Bao Z, Zhang QY, Smith TJ, Hong JY, Ding X.
    Cancer Res; 2000 Sep 15; 60(18):5074-9. PubMed ID: 11016631
    [Abstract] [Full Text] [Related]

  • 17. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by inducible and constitutive cytochrome P450 enzymes in rats.
    Guo Z, Smith TJ, Thomas PE, Yang CS.
    Arch Biochem Biophys; 1992 Oct 15; 298(1):279-86. PubMed ID: 1524438
    [Abstract] [Full Text] [Related]

  • 18. Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen.
    Carmella SG, Borukhova A, Akerkar SA, Hecht SS.
    Cancer Epidemiol Biomarkers Prev; 1997 Feb 15; 6(2):113-20. PubMed ID: 9037562
    [Abstract] [Full Text] [Related]

  • 19. Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes.
    Staretz ME, Murphy SE, Patten CJ, Nunes MG, Koehl W, Amin S, Koenig LA, Guengerich FP, Hecht SS.
    Drug Metab Dispos; 1997 Feb 15; 25(2):154-62. PubMed ID: 9029045
    [Abstract] [Full Text] [Related]

  • 20. Use of precision-cut tissue slices in organ culture to study metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by hamster lung, liver and kidney.
    Richter E, Friesenegger S, Engl J, Tricker AR.
    Toxicology; 2000 Apr 03; 144(1-3):83-91. PubMed ID: 10781874
    [Abstract] [Full Text] [Related]

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