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Journal Abstract Search

215 related items for PubMed ID: 17718553

  • 21. Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases.
    Norton RS, Pennington MW, Wulff H.
    Curr Med Chem; 2004 Dec; 11(23):3041-52. PubMed ID: 15578998
    [Abstract] [Full Text] [Related]

  • 22. ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide.
    Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, Chandy KG.
    J Biol Chem; 1998 Dec 04; 273(49):32697-707. PubMed ID: 9830012
    [Abstract] [Full Text] [Related]

  • 23. A helical capping motif in ShK toxin and its role in helix stabilization.
    Lanigan MD, Tudor JE, Pennington MW, Norton RS.
    Biopolymers; 2001 Apr 05; 58(4):422-36. PubMed ID: 11180055
    [Abstract] [Full Text] [Related]

  • 24. The molecular mechanism of toxin-induced conformational changes in a potassium channel: relation to C-type inactivation.
    Zachariae U, Schneider R, Velisetty P, Lange A, Seeliger D, Wacker SJ, Karimi-Nejad Y, Vriend G, Becker S, Pongs O, Baldus M, de Groot BL.
    Structure; 2008 May 05; 16(5):747-54. PubMed ID: 18462679
    [Abstract] [Full Text] [Related]

  • 25. The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation.
    Beeton C, Smith BJ, Sabo JK, Crossley G, Nugent D, Khaytin I, Chi V, Chandy KG, Pennington MW, Norton RS.
    J Biol Chem; 2008 Jan 11; 283(2):988-97. PubMed ID: 17984097
    [Abstract] [Full Text] [Related]

  • 26. Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3.
    Murray JK, Qian YX, Liu B, Elliott R, Aral J, Park C, Zhang X, Stenkilsson M, Salyers K, Rose M, Li H, Yu S, Andrews KL, Colombero A, Werner J, Gaida K, Sickmier EA, Miu P, Itano A, McGivern J, Gegg CV, Sullivan JK, Miranda LP.
    J Med Chem; 2015 Sep 10; 58(17):6784-802. PubMed ID: 26288216
    [Abstract] [Full Text] [Related]

  • 27. Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile.
    Middleton RE, Sanchez M, Linde AR, Bugianesi RM, Dai G, Felix JP, Koprak SL, Staruch MJ, Bruguera M, Cox R, Ghosh A, Hwang J, Jones S, Kohler M, Slaughter RS, McManus OB, Kaczorowski GJ, Garcia ML.
    Biochemistry; 2003 Nov 25; 42(46):13698-707. PubMed ID: 14622016
    [Abstract] [Full Text] [Related]

  • 28. Interaction of d-tubocurarine with potassium channels: molecular modeling and ligand binding.
    Rossokhin A, Teodorescu G, Grissmer S, Zhorov BS.
    Mol Pharmacol; 2006 Apr 25; 69(4):1356-65. PubMed ID: 16391240
    [Abstract] [Full Text] [Related]

  • 29. Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads.
    Chandy KG, Sanches K, Norton RS.
    Channels (Austin); 2023 Dec 25; 17(1):2253104. PubMed ID: 37695839
    [Abstract] [Full Text] [Related]

  • 30. Reinvestigation of the biological activity of d-allo-ShK protein.
    Dang B, Chhabra S, Pennington MW, Norton RS, Kent SBH.
    J Biol Chem; 2017 Jul 28; 292(30):12599-12605. PubMed ID: 28596383
    [Abstract] [Full Text] [Related]

  • 31. Ionisation behaviour and solution properties of the potassium-channel blocker ShK toxin.
    Tudor JE, Pennington MW, Norton RS.
    Eur J Biochem; 1998 Jan 15; 251(1-2):133-41. PubMed ID: 9492277
    [Abstract] [Full Text] [Related]

  • 32. A potassium-channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for Kv1 channels. Revision of the amino acid sequence, disulfide-bridge assignment, chemical synthesis, and biological activity.
    Cotton J, Crest M, Bouet F, Alessandri N, Gola M, Forest E, Karlsson E, Castañeda O, Harvey AL, Vita C, Ménez A.
    Eur J Biochem; 1997 Feb 15; 244(1):192-202. PubMed ID: 9063464
    [Abstract] [Full Text] [Related]

  • 33. In silico detection of binding mode of J-superfamily conotoxin pl14a with Kv1.6 channel.
    Mondal S, Babu RM, Bhavna R, Ramakumar S.
    In Silico Biol; 2007 Feb 15; 7(2):175-86. PubMed ID: 17688443
    [Abstract] [Full Text] [Related]

  • 34. Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK.
    Pennington MW, Chang SC, Chauhan S, Huq R, Tajhya RB, Chhabra S, Norton RS, Beeton C.
    Mar Drugs; 2015 Jan 16; 13(1):529-42. PubMed ID: 25603346
    [Abstract] [Full Text] [Related]

  • 35. Design and synthesis of type-III mimetics of ShK toxin.
    Baell JB, Harvey AJ, Norton RS.
    J Comput Aided Mol Des; 2002 Apr 16; 16(4):245-62. PubMed ID: 12400855
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