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161 related items for PubMed ID: 17786622

  • 1. Comparison of the 17 alpha-hydroxylase/C17,20-lyase activities of porcine, guinea pig and bovine P450c17 using purified recombinant fusion proteins containing P450c17 linked to NADPH-P450 reductase.
    Shet MS, Fisher CW, Tremblay Y, Belanger A, Conley AJ, Mason JI, Estabrook RW.
    Drug Metab Rev; 2007; 39(2-3):289-307. PubMed ID: 17786622
    [Abstract] [Full Text] [Related]

  • 2. NADPH-flavodoxin reductase and flavodoxin from Escherichia coli: characteristics as a soluble microsomal P450 reductase.
    Jenkins CM, Waterman MR.
    Biochemistry; 1998 Apr 28; 37(17):6106-13. PubMed ID: 9558349
    [Abstract] [Full Text] [Related]

  • 3. Purification and enzymatic properties of a recombinant fusion protein expressed in Escherichia coli containing the domains of bovine P450 17A and rat NADPH-P450 reductase.
    Shet MS, Fisher CW, Arlotto MP, Shackleton CH, Holmans PL, Martin-Wixtrom CA, Saeki Y, Estabrook RW.
    Arch Biochem Biophys; 1994 Jun 28; 311(2):402-17. PubMed ID: 8203904
    [Abstract] [Full Text] [Related]

  • 4. The function of recombinant cytochrome P450s in intact Escherichia coli cells: the 17 alpha-hydroxylation of progesterone and pregnenolone by P450c17.
    Shet MS, Fisher CW, Estabrook RW.
    Arch Biochem Biophys; 1997 Mar 01; 339(1):218-25. PubMed ID: 9056252
    [Abstract] [Full Text] [Related]

  • 5. Expression and purification of functional human 17 alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17 alpha-hydroxylase/17,20-lyase deficiency.
    Imai T, Globerman H, Gertner JM, Kagawa N, Waterman MR.
    J Biol Chem; 1993 Sep 15; 268(26):19681-9. PubMed ID: 8396144
    [Abstract] [Full Text] [Related]

  • 6. Modulation of 17alpha-hydroxylase/17,20-lyase activity of guinea pig cytochrome P450c17 by site-directed mutagenesis.
    Beaudoin C, Lavallée B, Tremblay Y, Hum DW, Breton R, de Launoit Y, Bélanger A.
    DNA Cell Biol; 1998 Aug 15; 17(8):707-15. PubMed ID: 9726253
    [Abstract] [Full Text] [Related]

  • 7. Molecular cloning and heterologous expression in E. coli of cytochrome P45017alpha. Comparison of structural and functional properties of substrate-specific cytochromes P450 from different species.
    Gilep AA, Estabrook RW, Usanov SA.
    Biochemistry (Mosc); 2003 Jan 15; 68(1):86-98. PubMed ID: 12693981
    [Abstract] [Full Text] [Related]

  • 8. Assessment of the ability of type 2 cytochrome b5 to modulate 17,20-lyase activity of human P450c17.
    Soucy P, Luu-The V.
    J Steroid Biochem Mol Biol; 2002 Jan 15; 80(1):71-5. PubMed ID: 11867265
    [Abstract] [Full Text] [Related]

  • 9. Cytochrome P450c17 from porcine and bovine adrenal catalyses the formation of 5,16-androstadien-3 beta-ol from pregnenolone in the presence of cytochrome b5.
    Meadus WJ, Mason JI, Squires EJ.
    J Steroid Biochem Mol Biol; 1993 Nov 15; 46(5):565-72. PubMed ID: 8240978
    [Abstract] [Full Text] [Related]

  • 10. Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor. Role of recombinant cytochrome b5 and P450 reductase.
    Soucy P, Lacoste L, Luu-The V.
    Eur J Biochem; 2003 Mar 15; 270(6):1349-55. PubMed ID: 12631293
    [Abstract] [Full Text] [Related]

  • 11. Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase.
    Lin D, Black SM, Nagahama Y, Miller WL.
    Endocrinology; 1993 Jun 15; 132(6):2498-506. PubMed ID: 8504753
    [Abstract] [Full Text] [Related]

  • 12. Genetically engineered P450 monooxygenases: construction of bovine P450c17/yeast reductase fused enzymes.
    Shibata M, Sakaki T, Yabusaki Y, Murakami H, Ohkawa H.
    DNA Cell Biol; 1990 Jun 15; 9(1):27-36. PubMed ID: 2180429
    [Abstract] [Full Text] [Related]

  • 13. Chimerogenesis in estimation of specificity and pathway directions for cytochrome p45017alpha catalyzed reactions.
    Gilep AA, Estabrook RW, Usanov SA.
    Biochemistry (Mosc); 2004 Apr 15; 69(4):364-75. PubMed ID: 15170370
    [Abstract] [Full Text] [Related]

  • 14. High-level expression in Escherichia coli of enzymatically active fusion proteins containing the domains of mammalian cytochromes P450 and NADPH-P450 reductase flavoprotein.
    Fisher CW, Shet MS, Caudle DL, Martin-Wixtrom CA, Estabrook RW.
    Proc Natl Acad Sci U S A; 1992 Nov 15; 89(22):10817-21. PubMed ID: 1438282
    [Abstract] [Full Text] [Related]

  • 15. Molecular cloning and expression of guinea pig cytochrome P450c17 cDNA (steroid 17 alpha-hydroxylase/17,20 lyase): tissue distribution, regulation, and substrate specificity of the expressed enzyme.
    Tremblay Y, Fleury A, Beaudoin C, Vallée M, Bélanger A.
    DNA Cell Biol; 1994 Dec 15; 13(12):1199-212. PubMed ID: 7811386
    [Abstract] [Full Text] [Related]

  • 16. Biochemical differences between rat and human cytochrome P450c17 support the different steroidogenic needs of these two species.
    Brock BJ, Waterman MR.
    Biochemistry; 1999 Feb 02; 38(5):1598-606. PubMed ID: 9931027
    [Abstract] [Full Text] [Related]

  • 17. Conversion of pregnenolone to DHEA by human 17alpha-hydroxylase/17, 20-lyase (P450c17). Evidence that DHEA is produced from the released intermediate, 17alpha-hydroxypregnenolone.
    Soucy P, Luu-The V.
    Eur J Biochem; 2000 Jun 02; 267(11):3243-7. PubMed ID: 10824109
    [Abstract] [Full Text] [Related]

  • 18. Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations.
    Auchus RJ, Miller WL.
    Mol Endocrinol; 1999 Jul 02; 13(7):1169-82. PubMed ID: 10406467
    [Abstract] [Full Text] [Related]

  • 19. Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.
    Gonzalez E, Guengerich FP.
    J Biol Chem; 2017 Aug 11; 292(32):13168-13185. PubMed ID: 28684414
    [Abstract] [Full Text] [Related]

  • 20. The use of electrochemistry for the synthesis of 17 alpha-hydroxyprogesterone by a fusion protein containing P450c17.
    Estabrook RW, Shet MS, Faulkner K, Fisher CW.
    Endocr Res; 1996 Nov 11; 22(4):665-71. PubMed ID: 8969926
    [Abstract] [Full Text] [Related]

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