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Journal Abstract Search

214 related items for PubMed ID: 17827153

  • 1. Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.
    Li T, Wen H, Brayton C, Das P, Smithson LA, Fauq A, Fan X, Crain BJ, Price DL, Golde TE, Eberhart CG, Wong PC.
    J Biol Chem; 2007 Nov 02; 282(44):32264-73. PubMed ID: 17827153
    [Abstract] [Full Text] [Related]

  • 2. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
    Li T, Ma G, Cai H, Price DL, Wong PC.
    J Neurosci; 2003 Apr 15; 23(8):3272-7. PubMed ID: 12716934
    [Abstract] [Full Text] [Related]

  • 3. Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.
    Teranishi Y, Inoue M, Yamamoto NG, Kihara T, Wiehager B, Ishikawa T, Winblad B, Schedin-Weiss S, Frykman S, Tjernberg LO.
    FEBS J; 2015 Sep 15; 282(17):3438-51. PubMed ID: 26094765
    [Abstract] [Full Text] [Related]

  • 4. A novel triazole, NMK-T-057, induces autophagic cell death in breast cancer cells by inhibiting γ-secretase-mediated activation of Notch signaling.
    Das A, Narayanam MK, Paul S, Mukhnerjee P, Ghosh S, Dastidar DG, Chakrabarty S, Ganguli A, Basu B, Pal M, Chatterji U, Banerjee SK, Karmakar P, Kumar D, Chakrabarti G.
    J Biol Chem; 2019 Apr 26; 294(17):6733-6750. PubMed ID: 30824542
    [Abstract] [Full Text] [Related]

  • 5. Similar mechanisms regulated by gamma-secretase are involved in both directions of the bi-directional Notch-Delta signaling pathway as well as play a potential role in signaling events involving type 1 transmembrane proteins.
    Nakayama K, Nagase H, Hiratochi M, Koh CS, Ohkawara T.
    Curr Stem Cell Res Ther; 2008 Dec 26; 3(4):288-302. PubMed ID: 19075758
    [Abstract] [Full Text] [Related]

  • 6. Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression.
    Zhang YW, Wang R, Liu Q, Zhang H, Liao FF, Xu H.
    Proc Natl Acad Sci U S A; 2007 Jun 19; 104(25):10613-8. PubMed ID: 17556541
    [Abstract] [Full Text] [Related]

  • 7. Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.
    Yang T, Arslanova D, Gu Y, Augelli-Szafran C, Xia W.
    Mol Brain; 2008 Nov 04; 1():15. PubMed ID: 18983676
    [Abstract] [Full Text] [Related]

  • 8. Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities.
    Li T, Wen H, Brayton C, Laird FM, Ma G, Peng S, Placanica L, Wu TC, Crain BJ, Price DL, Eberhart CG, Wong PC.
    J Neurosci; 2007 Oct 03; 27(40):10849-59. PubMed ID: 17913918
    [Abstract] [Full Text] [Related]

  • 9. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.
    J Pharmacol Exp Ther; 2009 Nov 03; 331(2):598-608. PubMed ID: 19671883
    [Abstract] [Full Text] [Related]

  • 10. Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design.
    Wei P, Walls M, Qiu M, Ding R, Denlinger RH, Wong A, Tsaparikos K, Jani JP, Hosea N, Sands M, Randolph S, Smeal T.
    Mol Cancer Ther; 2010 Jun 03; 9(6):1618-28. PubMed ID: 20530712
    [Abstract] [Full Text] [Related]

  • 11. γ-Secretase-regulated signaling typified by Notch signaling in the immune system.
    Nagase H, Nakayama K.
    Curr Stem Cell Res Ther; 2013 Sep 03; 8(5):341-56. PubMed ID: 23957936
    [Abstract] [Full Text] [Related]

  • 12. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage.
    Chyung JH, Raper DM, Selkoe DJ.
    J Biol Chem; 2005 Feb 11; 280(6):4383-92. PubMed ID: 15569674
    [Abstract] [Full Text] [Related]

  • 13. A fast growing spectrum of biological functions of γ-secretase in development and disease.
    Jurisch-Yaksi N, Sannerud R, Annaert W.
    Biochim Biophys Acta; 2013 Dec 11; 1828(12):2815-27. PubMed ID: 24099003
    [Abstract] [Full Text] [Related]

  • 14. Ethanol inhibits γ-secretase proteolytic activity in vascular smooth muscle cells.
    Hatch E, Morrow D, Liu W, Cahill PA, Redmond EM.
    Alcohol Clin Exp Res; 2015 Nov 11; 39(11):2115-22. PubMed ID: 26443551
    [Abstract] [Full Text] [Related]

  • 15. Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.
    Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT.
    J Biol Chem; 2003 Nov 28; 278(48):47370-5. PubMed ID: 12960155
    [Abstract] [Full Text] [Related]

  • 16. A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells.
    Saito N, Fu J, Zheng S, Yao J, Wang S, Liu DD, Yuan Y, Sulman EP, Lang FF, Colman H, Verhaak RG, Yung WK, Koul D.
    Stem Cells; 2014 Jan 28; 32(1):301-12. PubMed ID: 24038660
    [Abstract] [Full Text] [Related]

  • 17. Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke.
    Arumugam TV, Cheng YL, Choi Y, Choi YH, Yang S, Yun YK, Park JS, Yang DK, Thundyil J, Gelderblom M, Karamyan VT, Tang SC, Chan SL, Magnus T, Sobey CG, Jo DG.
    Mol Pharmacol; 2011 Jul 28; 80(1):23-31. PubMed ID: 21450930
    [Abstract] [Full Text] [Related]

  • 18. Gamma-secretase and the intramembrane proteolysis of Notch.
    Jorissen E, De Strooper B.
    Curr Top Dev Biol; 2010 Jul 28; 92():201-30. PubMed ID: 20816396
    [Abstract] [Full Text] [Related]

  • 19. Synthetic lethality through combined Notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer.
    Dong Y, Li A, Wang J, Weber JD, Michel LS.
    Cancer Res; 2010 Jul 01; 70(13):5465-74. PubMed ID: 20570903
    [Abstract] [Full Text] [Related]

  • 20. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
    Frånberg J, Svensson AI, Winblad B, Karlström H, Frykman S.
    Biochem Biophys Res Commun; 2011 Jan 07; 404(1):564-8. PubMed ID: 21146496
    [Abstract] [Full Text] [Related]

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