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Journal Abstract Search

268 related items for PubMed ID: 17854801

  • 1. Two neighboring residues of loop A of the alpha1 subunit point towards the benzodiazepine binding site of GABAA receptors.
    Tan KR, Baur R, Gonthier A, Goeldner M, Sigel E.
    FEBS Lett; 2007 Oct 02; 581(24):4718-22. PubMed ID: 17854801
    [Abstract] [Full Text] [Related]

  • 2. Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs.
    Baur R, Tan KR, Lüscher BP, Gonthier A, Goeldner M, Sigel E.
    J Neurochem; 2008 Sep 02; 106(6):2353-63. PubMed ID: 18643789
    [Abstract] [Full Text] [Related]

  • 3. Relative positioning of diazepam in the benzodiazepine-binding-pocket of GABA receptors.
    Tan KR, Baur R, Charon S, Goeldner M, Sigel E.
    J Neurochem; 2009 Dec 02; 111(5):1264-73. PubMed ID: 19804380
    [Abstract] [Full Text] [Related]

  • 4. The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits.
    Balic E, Rudolph U, Fritschy JM, Mohler H, Benke D.
    J Neurochem; 2009 Jul 02; 110(1):244-54. PubMed ID: 19457072
    [Abstract] [Full Text] [Related]

  • 5. Alterations of the benzodiazepine site of rat alpha 6 beta 2 gamma 2-GABAA receptor by replacement of several divergent amino-terminal regions with the alpha 1 counterparts.
    Im WB, Pregenzer JF, Binder JA, Alberts GL, Im HK.
    Br J Pharmacol; 1997 Feb 02; 120(4):559-64. PubMed ID: 9051290
    [Abstract] [Full Text] [Related]

  • 6. Conformational changes at benzodiazepine binding sites of GABA(A) receptors detected with a novel technique.
    Berezhnoy D, Baur R, Gonthier A, Foucaud B, Goeldner M, Sigel E.
    J Neurochem; 2005 Feb 02; 92(4):859-66. PubMed ID: 15686488
    [Abstract] [Full Text] [Related]

  • 7. Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.
    Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O'Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR.
    J Psychopharmacol; 2007 Jun 02; 21(4):384-91. PubMed ID: 17092983
    [Abstract] [Full Text] [Related]

  • 8. Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit.
    Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart W.
    Biochem Pharmacol; 2004 Oct 15; 68(8):1621-9. PubMed ID: 15451405
    [Abstract] [Full Text] [Related]

  • 9. Indiplon is a high-affinity positive allosteric modulator with selectivity for alpha1 subunit-containing GABAA receptors.
    Petroski RE, Pomeroy JE, Das R, Bowman H, Yang W, Chen AP, Foster AC.
    J Pharmacol Exp Ther; 2006 Apr 15; 317(1):369-77. PubMed ID: 16399882
    [Abstract] [Full Text] [Related]

  • 10. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.
    McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, Farrar S, Myers J, Cook G, Ferris P, Garrett L, Bristow L, Marshall G, Macaulay A, Brown N, Howell O, Moore KW, Carling RW, Street LJ, Castro JL, Ragan CI, Dawson GR, Whiting PJ.
    Nat Neurosci; 2000 Jun 15; 3(6):587-92. PubMed ID: 10816315
    [Abstract] [Full Text] [Related]

  • 11. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.
    Rudolph U, Crestani F, Benke D, Brünig I, Benson JA, Fritschy JM, Martin JR, Bluethmann H, Möhler H.
    Nature; 1999 Oct 21; 401(6755):796-800. PubMed ID: 10548105
    [Abstract] [Full Text] [Related]

  • 12. A closer look at the high affinity benzodiazepine binding site on GABAA receptors.
    Sigel E, Lüscher BP.
    Curr Top Med Chem; 2011 Oct 21; 11(2):241-6. PubMed ID: 21189125
    [Abstract] [Full Text] [Related]

  • 13. Identification of benzodiazepine binding site residues in the gamma2 subunit of the gamma-aminobutyric acid(A) receptor.
    Kucken AM, Wagner DA, Ward PR, Teissére JA, Boileau AJ, Czajkowski C.
    Mol Pharmacol; 2000 May 21; 57(5):932-9. PubMed ID: 10779376
    [Abstract] [Full Text] [Related]

  • 14. Affinity of 3-acyl substituted 4-quinolones at the benzodiazepine site of GABA(A) receptors.
    Lager E, Nilsson J, Østergaard Nielsen E, Nielsen M, Liljefors T, Sterner O.
    Bioorg Med Chem; 2008 Jul 15; 16(14):6936-48. PubMed ID: 18541432
    [Abstract] [Full Text] [Related]

  • 15. GABAA receptor pharmacology of fluorinated derivatives of the novel sedative-hypnotic pyrazolopyrimidine indiplon.
    Wegner F, Deuther-Conrad W, Scheunemann M, Brust P, Fischer S, Hiller A, Diekers M, Strecker K, Wohlfarth K, Allgaier C, Steinbach J, Hoepping A.
    Eur J Pharmacol; 2008 Feb 02; 580(1-2):1-11. PubMed ID: 18035350
    [Abstract] [Full Text] [Related]

  • 16. 3,4-Dihydronaphthalen-1(2H)-ones: novel ligands for the benzodiazepine site of alpha5-containing GABAA receptors.
    Szekeres HJ, Atack JR, Chambers MS, Cook SM, Macaulay AJ, Pillai GV, MacLeod AM.
    Bioorg Med Chem Lett; 2004 Jun 07; 14(11):2871-5. PubMed ID: 15125950
    [Abstract] [Full Text] [Related]

  • 17. A residue close to α1 loop F disrupts modulation of GABAA receptors by benzodiazepines while their binding is maintained.
    Baur R, Lüscher BP, Richter L, Sigel E.
    J Neurochem; 2010 Dec 07; 115(6):1478-85. PubMed ID: 20946417
    [Abstract] [Full Text] [Related]

  • 18. Type A gamma-aminobutyric acid (GABAA) receptor subunits and benzodiazepine binding: significance to clinical syndromes and their treatment.
    Smith TA.
    Br J Biomed Sci; 2001 Dec 07; 58(2):111-21. PubMed ID: 11440203
    [Abstract] [Full Text] [Related]

  • 19. Identification of a residue in the gamma-aminobutyric acid type A receptor alpha subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding.
    Derry JM, Dunn SM, Davies M.
    J Neurochem; 2004 Mar 07; 88(6):1431-8. PubMed ID: 15009644
    [Abstract] [Full Text] [Related]

  • 20. New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds.
    Anzini M, Valenti S, Braile C, Cappelli A, Vomero S, Alcaro S, Ortuso F, Marinelli L, Limongelli V, Novellino E, Betti L, Giannaccini G, Lucacchini A, Daniele S, Martini C, Ghelardini C, Di Cesare Mannelli L, Giorgi G, Mascia MP, Biggio G.
    J Med Chem; 2011 Aug 25; 54(16):5694-711. PubMed ID: 21751815
    [Abstract] [Full Text] [Related]

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