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228 related items for PubMed ID: 17875936

  • 1. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.
    Falsetti SC, Wang DA, Peng H, Carrico D, Cox AD, Der CJ, Hamilton AD, Sebti SM.
    Mol Cell Biol; 2007 Nov; 27(22):8003-14. PubMed ID: 17875936
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  • 2. Involvement of RhoA and RalB in geranylgeranyltransferase I inhibitor-mediated inhibition of proliferation and migration of human oral squamous cell carcinoma cells.
    Hamada M, Miki T, Iwai S, Shimizu H, Yura Y.
    Cancer Chemother Pharmacol; 2011 Sep; 68(3):559-69. PubMed ID: 21107573
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  • 3. Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis.
    Dan HC, Jiang K, Coppola D, Hamilton A, Nicosia SV, Sebti SM, Cheng JQ.
    Oncogene; 2004 Jan 22; 23(3):706-15. PubMed ID: 14737105
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  • 5. Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I.
    Chan LN, Fiji HD, Watanabe M, Kwon O, Tamanoi F.
    PLoS One; 2011 Jan 22; 6(10):e26135. PubMed ID: 22028818
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  • 10. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
    Lobell RB, Omer CA, Abrams MT, Bhimnathwala HG, Brucker MJ, Buser CA, Davide JP, deSolms SJ, Dinsmore CJ, Ellis-Hutchings MS, Kral AM, Liu D, Lumma WC, Machotka SV, Rands E, Williams TM, Graham SL, Hartman GD, Oliff AI, Heimbrook DC, Kohl NE.
    Cancer Res; 2001 Dec 15; 61(24):8758-68. PubMed ID: 11751396
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  • 11. Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
    Lerner EC, Zhang TT, Knowles DB, Qian Y, Hamilton AD, Sebti SM.
    Oncogene; 1997 Sep 15; 15(11):1283-8. PubMed ID: 9315095
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  • 12. RalA and RalB proteins are ubiquitinated GTPases, and ubiquitinated RalA increases lipid raft exposure at the plasma membrane.
    Neyraud V, Aushev VN, Hatzoglou A, Meunier B, Cascone I, Camonis J.
    J Biol Chem; 2012 Aug 24; 287(35):29397-405. PubMed ID: 22700969
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  • 14. RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival.
    Chien Y, White MA.
    EMBO Rep; 2003 Aug 24; 4(8):800-6. PubMed ID: 12856001
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  • 17. Differential involvement of RalA and RalB in colorectal cancer.
    Martin TD, Der CJ.
    Small GTPases; 2012 Aug 24; 3(2):126-30. PubMed ID: 22790202
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  • 19. Activation and involvement of Ral GTPases in colorectal cancer.
    Martin TD, Samuel JC, Routh ED, Der CJ, Yeh JJ.
    Cancer Res; 2011 Jan 01; 71(1):206-15. PubMed ID: 21199803
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  • 20. Contributions of KRAS and RAL in non-small-cell lung cancer growth and progression.
    Guin S, Ru Y, Wynes MW, Mishra R, Lu X, Owens C, Barn AE, Vasu VT, Hirsch FR, Kern JA, Theodorescu D.
    J Thorac Oncol; 2013 Dec 01; 8(12):1492-501. PubMed ID: 24389431
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