These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

389 related items for PubMed ID: 17881660

  • 1. Cyclic conversion of the novel Src kinase inhibitor [7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its N-oxide metabolite by flavin-containing monoxygenases and cytochrome P450 reductase.
    Kousba A, Soll R, Yee S, Martin M.
    Drug Metab Dispos; 2007 Dec; 35(12):2242-51. PubMed ID: 17881660
    [Abstract] [Full Text] [Related]

  • 2. Metabolism and pharmacokinetics of a novel Src kinase inhibitor TG100435 ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and its active N-oxide metabolite TG100855 ([7-(2,6-dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine).
    Hu SX, Soll R, Yee S, Lohse DL, Kousba A, Zeng B, Yu X, McPherson A, Renick J, Cao J, Tabak A, Hood J, Doukas J, Noronha G, Martin M.
    Drug Metab Dispos; 2007 Jun; 35(6):929-36. PubMed ID: 17371799
    [Abstract] [Full Text] [Related]

  • 3. Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes.
    Rawden HC, Kokwaro GO, Ward SA, Edwards G.
    Br J Clin Pharmacol; 2000 Apr; 49(4):313-22. PubMed ID: 10759686
    [Abstract] [Full Text] [Related]

  • 4. A convenient method to discriminate between cytochrome P450 enzymes and flavin-containing monooxygenases in human liver microsomes.
    Grothusen A, Hardt J, Bräutigam L, Lang D, Böcker R.
    Arch Toxicol; 1996 Apr; 71(1-2):64-71. PubMed ID: 9010587
    [Abstract] [Full Text] [Related]

  • 5. In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P4503A4 and NADPH-P450 reductase. Comparison to human liver microsomes and precision-cut liver tissue slices.
    Rodrigues AD, Mulford DJ, Lee RD, Surber BW, Kukulka MJ, Ferrero JL, Thomas SB, Shet MS, Estabrook RW.
    Drug Metab Dispos; 1995 Jul; 23(7):765-75. PubMed ID: 7587966
    [Abstract] [Full Text] [Related]

  • 6. Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase.
    Arlt VM, Stiborova M, Hewer A, Schmeiser HH, Phillips DH.
    Cancer Res; 2003 Jun 01; 63(11):2752-61. PubMed ID: 12782579
    [Abstract] [Full Text] [Related]

  • 7. Identification of human cytochrome P450 enzymes involved in the metabolism of IN-1130, a novel activin receptor-like kinase-5 (ALK5) inhibitor.
    Kim YW, Kim YK, Kim DK, Sheen YY.
    Xenobiotica; 2008 May 01; 38(5):451-64. PubMed ID: 18421620
    [Abstract] [Full Text] [Related]

  • 8. Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin.
    Parte P, Kupfer D.
    Drug Metab Dispos; 2005 Oct 01; 33(10):1446-52. PubMed ID: 15987777
    [Abstract] [Full Text] [Related]

  • 9. In vitro metabolism of clindamycin in human liver and intestinal microsomes.
    Wynalda MA, Hutzler JM, Koets MD, Podoll T, Wienkers LC.
    Drug Metab Dispos; 2003 Jul 01; 31(7):878-87. PubMed ID: 12814964
    [Abstract] [Full Text] [Related]

  • 10. Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).
    Uehara S, Uno Y, Inoue T, Murayama N, Shimizu M, Sasaki E, Yamazaki H.
    Drug Metab Dispos; 2015 May 01; 43(5):735-42. PubMed ID: 25735838
    [Abstract] [Full Text] [Related]

  • 11. CYP3A4 expressed by insect cells infected with a recombinant baculovirus containing both CYP3A4 and human NADPH-cytochrome P450 reductase is catalytically similar to human liver microsomal CYP3A4.
    Lee CA, Kadwell SH, Kost TA, Serabjit-Singh CJ.
    Arch Biochem Biophys; 1995 May 10; 319(1):157-67. PubMed ID: 7771780
    [Abstract] [Full Text] [Related]

  • 12.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 13.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 14. In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes.
    Zhang Y, Guo X, Lin ET, Benet LZ.
    Pharmacology; 1999 Mar 10; 58(3):147-59. PubMed ID: 9925971
    [Abstract] [Full Text] [Related]

  • 15. Stereoselective metabolism of endosulfan by human liver microsomes and human cytochrome P450 isoforms.
    Lee HK, Moon JK, Chang CH, Choi H, Park HW, Park BS, Lee HS, Hwang EC, Lee YD, Liu KH, Kim JH.
    Drug Metab Dispos; 2006 Jul 10; 34(7):1090-5. PubMed ID: 16581944
    [Abstract] [Full Text] [Related]

  • 16. The imidazoacridinone antitumor drug, C-1311, is metabolized by flavin monooxygenases but not by cytochrome P450s.
    Potega A, Dabrowska E, Niemira M, Kot-Wasik A, Ronseaux S, Henderson CJ, Wolf CR, Mazerska Z.
    Drug Metab Dispos; 2011 Aug 10; 39(8):1423-32. PubMed ID: 21555506
    [Abstract] [Full Text] [Related]

  • 17. A novel class of cytochrome P450 reductase redox cyclers: cationic manganoporphyrins.
    Day BJ, Kariya C.
    Toxicol Sci; 2005 May 10; 85(1):713-9. PubMed ID: 15703263
    [Abstract] [Full Text] [Related]

  • 18. Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes.
    Zhang WV, D'Esposito F, Edwards RJ, Ramzan I, Murray M.
    Drug Metab Dispos; 2008 Dec 10; 36(12):2547-55. PubMed ID: 18809730
    [Abstract] [Full Text] [Related]

  • 19. Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT(1D) receptor agonist.
    Prueksaritanont T, Lu P, Gorham L, Sternfeld F, Vyas KP.
    Xenobiotica; 2000 Jan 10; 30(1):47-59. PubMed ID: 10659950
    [Abstract] [Full Text] [Related]

  • 20.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 20.