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Journal Abstract Search

870 related items for PubMed ID: 17892269

  • 1. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
    Driscoll JP, Kornecki K, Wolkowski JP, Chupak L, Kalgutkar AS, O'Donnell JP.
    Chem Res Toxicol; 2007 Oct; 20(10):1488-97. PubMed ID: 17892269
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  • 2. Selective pathways for the metabolism of phencyclidine by cytochrome p450 2b enzymes: identification of electrophilic metabolites, glutathione, and N-acetyl cysteine adducts.
    Shebley M, Jushchyshyn MI, Hollenberg PF.
    Drug Metab Dispos; 2006 Mar; 34(3):375-83. PubMed ID: 16326815
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  • 4. Mechanism of inactivation of human cytochrome P450 2B6 by phencyclidine.
    Jushchyshyn MI, Wahlstrom JL, Hollenberg PF, Wienkers LC.
    Drug Metab Dispos; 2006 Sep; 34(9):1523-9. PubMed ID: 16782764
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  • 5. Mutation of a single residue (K262R) in P450 2B6 leads to loss of mechanism-based inactivation by phencyclidine.
    Shebley M, Hollenberg PF.
    Drug Metab Dispos; 2007 Aug; 35(8):1365-71. PubMed ID: 17460030
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  • 6. Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.
    Wen B, Chen Y, Fitch WL.
    Drug Metab Dispos; 2009 Jul; 37(7):1557-62. PubMed ID: 19364830
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  • 7. Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile.
    Wang Y, Zhong D, Chen X, Zheng J.
    Chem Res Toxicol; 2009 May; 22(5):824-34. PubMed ID: 19358519
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  • 8. Evidence for the bioactivation of 4-nonylphenol to quinone methide and ortho-benzoquinone metabolites in human liver microsomes.
    Deng P, Zhong D, Nan F, Liu S, Li D, Yuan T, Chen X, Zheng J.
    Chem Res Toxicol; 2010 Oct 18; 23(10):1617-28. PubMed ID: 20843008
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  • 9. Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes.
    Iverson SL, Shen L, Anlar N, Bolton JL.
    Chem Res Toxicol; 1996 Mar 18; 9(2):492-9. PubMed ID: 8839054
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  • 10. Metabolism of phencyclidine by human liver microsomes.
    Laurenzana EM, Owens SM.
    Drug Metab Dispos; 1997 May 18; 25(5):557-63. PubMed ID: 9152594
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  • 15. Bioactivation of 4-methylphenol (p-cresol) via cytochrome P450-mediated aromatic oxidation in human liver microsomes.
    Yan Z, Zhong HM, Maher N, Torres R, Leo GC, Caldwell GW, Huebert N.
    Drug Metab Dispos; 2005 Dec 18; 33(12):1867-76. PubMed ID: 16174805
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  • 16. The mechanism-based inactivation of human cytochrome P450 2B6 by phencyclidine.
    Jushchyshyn MI, Kent UM, Hollenberg PF.
    Drug Metab Dispos; 2003 Jan 18; 31(1):46-52. PubMed ID: 12485952
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  • 18. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
    Chen Q, Doss GA, Tung EC, Liu W, Tang YS, Braun MP, Didolkar V, Strauss JR, Wang RW, Stearns RA, Evans DC, Baillie TA, Tang W.
    Drug Metab Dispos; 2006 Jan 18; 34(1):145-51. PubMed ID: 16251255
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  • 19. Metabolic inactivation of cytochrome P4502B1 by phencyclidine: immunochemical and radiochemical analyses of the protective effects of glutathione.
    Sharma U, Roberts ES, Kent UM, Owens SM, Hollenberg PF.
    Drug Metab Dispos; 1997 Feb 18; 25(2):243-50. PubMed ID: 9029055
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