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187 related items for PubMed ID: 17893518

  • 1. HSP90 antagonist, geldanamycin, inhibits proliferation, induces apoptosis and blocks migration of rhabdomyosarcoma cells in vitro and seeding into bone marrow in vivo.
    Lesko E, Gozdzik J, Kijowski J, Jenner B, Wiecha O, Majka M.
    Anticancer Drugs; 2007 Nov; 18(10):1173-81. PubMed ID: 17893518
    [Abstract] [Full Text] [Related]

  • 2. High anti tumor activity against rhabdomyosarcoma cells and low normal cells cytotoxicity of heat shock protein 90 inhibitors, with special emphasis on 17-[2-(pyrrolidin-1-yl)ethyl]-aminno-17-demethoxygeldanamycin.
    Lukasiewicz E, Miekus K, Kijowski J, Gozdzik J, Wilusz M, Bobis-Wozowicz S, Wiecha O, Majka M.
    J Physiol Pharmacol; 2009 Sep; 60(3):161-6. PubMed ID: 19826195
    [Abstract] [Full Text] [Related]

  • 3. Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.
    Schwock J, Pham NA, Cao MP, Hedley DW.
    Cancer Chemother Pharmacol; 2008 Apr; 61(4):669-81. PubMed ID: 17579866
    [Abstract] [Full Text] [Related]

  • 4. 17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion.
    Miekus K, Kijowski J, Sekuła M, Majka M.
    Oncol Rep; 2012 Nov; 28(5):1903-9. PubMed ID: 22941268
    [Abstract] [Full Text] [Related]

  • 5. The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation.
    Jeon YK, Park CH, Kim KY, Li YC, Kim J, Kim YA, Paik JH, Park BK, Kim CW, Kim YN.
    J Pathol; 2007 Oct; 213(2):170-9. PubMed ID: 17768706
    [Abstract] [Full Text] [Related]

  • 6. Proteome-wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells.
    Schumacher JA, Crockett DK, Elenitoba-Johnson KS, Lim MS.
    Proteomics; 2007 Aug; 7(15):2603-16. PubMed ID: 17610208
    [Abstract] [Full Text] [Related]

  • 7. Geldanamycin and its analog induce cytotoxicity in cultured human retinal pigment epithelial cells.
    Wu WC, Wu MH, Chang YC, Hsieh MC, Wu HJ, Cheng KC, Lai YH, Kao YH.
    Exp Eye Res; 2010 Aug; 91(2):211-9. PubMed ID: 20493187
    [Abstract] [Full Text] [Related]

  • 8. The Hsp90 inhibitor 17-allylamide-17-demethoxygeldanamycin induces apoptosis and differentiation of Kasumi-1 harboring the Asn822Lys KIT mutation and down-regulates KIT protein level.
    Yu W, Rao Q, Wang M, Tian Z, Lin D, Liu X, Wang J.
    Leuk Res; 2006 May; 30(5):575-82. PubMed ID: 16213582
    [Abstract] [Full Text] [Related]

  • 9. Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection.
    Demidenko ZN, Vivo C, Halicka HD, Li CJ, Bhalla K, Broude EV, Blagosklonny MV.
    Cell Death Differ; 2006 Sep; 13(9):1434-41. PubMed ID: 16311509
    [Abstract] [Full Text] [Related]

  • 10. Geldanamycin induces mitotic catastrophe and subsequent apoptosis in human glioma cells.
    Nomura M, Nomura N, Newcomb EW, Lukyanov Y, Tamasdan C, Zagzag D.
    J Cell Physiol; 2004 Dec; 201(3):374-84. PubMed ID: 15389545
    [Abstract] [Full Text] [Related]

  • 11. [Effect of HSP90 function inhibited on the telomerase and P53 mutant in breast cancer cells].
    Li X, Deng HY.
    Sichuan Da Xue Xue Bao Yi Xue Ban; 2008 Mar; 39(2):181-3. PubMed ID: 18630678
    [Abstract] [Full Text] [Related]

  • 12. Geldanamycin inhibits tyrosine phosphorylation-dependent NF-kappaB activation.
    Crèvecoeur J, Merville MP, Piette J, Gloire G.
    Biochem Pharmacol; 2008 Jun 01; 75(11):2183-91. PubMed ID: 18455150
    [Abstract] [Full Text] [Related]

  • 13. HSP90 inhibitor 17AAG causes apoptosis in ATRA-resistant acute promyelocytic leukemia cells.
    Meyer PN, Roychowdhury S, Kini AR, Alkan S.
    Leuk Res; 2008 Jan 01; 32(1):143-9. PubMed ID: 17617451
    [Abstract] [Full Text] [Related]

  • 14. Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma.
    Francis LK, Alsayed Y, Leleu X, Jia X, Singha UK, Anderson J, Timm M, Ngo H, Lu G, Huston A, Ehrlich LA, Dimmock E, Lentzsch S, Hideshima T, Roodman GD, Anderson KC, Ghobrial IM.
    Clin Cancer Res; 2006 Nov 15; 12(22):6826-35. PubMed ID: 17121904
    [Abstract] [Full Text] [Related]

  • 15. Geldanamycin induces G2 arrest in U87MG glioblastoma cells through downregulation of Cdc2 and cyclin B1.
    Nomura N, Nomura M, Newcomb EW, Zagzag D.
    Biochem Pharmacol; 2007 May 15; 73(10):1528-36. PubMed ID: 17324379
    [Abstract] [Full Text] [Related]

  • 16. [The heat shock protein 90 inhibitor induces apoptosis and differentiation of Kasumi-1 and its mechanisms].
    Yu WJ, Rao Q, Wang M, Tian Z, Liu XR, Lin D, Wang JX.
    Zhonghua Xue Ye Xue Za Zhi; 2005 Dec 15; 26(12):728-31. PubMed ID: 16620576
    [Abstract] [Full Text] [Related]

  • 17. Geldanamycin interferes with the 90-kDa heat shock protein, affecting lipopolysaccharide-mediated interleukin-1 expression and apoptosis within macrophages.
    Hsu HY, Wu HL, Tan SK, Li VP, Wang WT, Hsu J, Cheng CH.
    Mol Pharmacol; 2007 Jan 15; 71(1):344-56. PubMed ID: 16868182
    [Abstract] [Full Text] [Related]

  • 18. The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells.
    Farina AR, Tacconelli A, Cappabianca L, Cea G, Chioda A, Romanelli A, Pensato S, Pedone C, Gulino A, Mackay AR.
    Oncogene; 2009 Nov 19; 28(46):4075-94. PubMed ID: 19734938
    [Abstract] [Full Text] [Related]

  • 19. Analysis of hypoxia-inducible factor-1alpha accumulation and cell cycle in geldanamycin-treated human cervical carcinoma cells by laser scanning cytometry.
    Schwock J, Geddie WR, Hedley DW.
    Cytometry A; 2005 Dec 19; 68(2):59-70. PubMed ID: 16228978
    [Abstract] [Full Text] [Related]

  • 20. Resistance to geldanamycin-induced apoptosis in differentiated neuroblastoma SH-SY5Y cells.
    Shen JH, Zhang Y, Wu NH, Shen YF.
    Neurosci Lett; 2007 Mar 06; 414(2):110-4. PubMed ID: 17293044
    [Abstract] [Full Text] [Related]

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