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Journal Abstract Search

824 related items for PubMed ID: 17896325

  • 1. Approach to predict the contribution of cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage: the effect of the expression of cytochrome b(5) with recombinant P450 enzymes.
    Emoto C, Iwasaki K.
    Xenobiotica; 2007 Sep; 37(9):986-99. PubMed ID: 17896325
    [Abstract] [Full Text] [Related]

  • 2. In vitro metabolism of the calmodulin antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) by human liver microsomes: involvement of cytochromes p450 in atypical kinetics and potential drug interactions.
    Tachibana S, Fujimaki Y, Yokoyama H, Okazaki O, Sudo K.
    Drug Metab Dispos; 2005 Nov; 33(11):1628-36. PubMed ID: 16049129
    [Abstract] [Full Text] [Related]

  • 3. Identification and relative contributions of human cytochrome P450 isoforms involved in the metabolism of glibenclamide and lansoprazole: evaluation of an approach based on the in vitro substrate disappearance rate.
    Naritomi Y, Terashita S, Kagayama A.
    Xenobiotica; 2004 May; 34(5):415-27. PubMed ID: 15370958
    [Abstract] [Full Text] [Related]

  • 4. Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib.
    Uttamsingh V, Lu C, Miwa G, Gan LS.
    Drug Metab Dispos; 2005 Nov; 33(11):1723-8. PubMed ID: 16103134
    [Abstract] [Full Text] [Related]

  • 5. Optimizing higher throughput methods to assess drug-drug interactions for CYP1A2, CYP2C9, CYP2C19, CYP2D6, rCYP2D6, and CYP3A4 in vitro using a single point IC(50).
    Gao F, Johnson DL, Ekins S, Janiszewski J, Kelly KG, Meyer RD, West M.
    J Biomol Screen; 2002 Aug; 7(4):373-82. PubMed ID: 12230892
    [Abstract] [Full Text] [Related]

  • 6. Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes.
    Murayama N, Imai N, Nakane T, Shimizu M, Yamazaki H.
    Biochem Pharmacol; 2007 Jun 15; 73(12):2020-6. PubMed ID: 17433262
    [Abstract] [Full Text] [Related]

  • 7. Identification of the human cytochromes P450 responsible for atomoxetine metabolism.
    Ring BJ, Gillespie JS, Eckstein JA, Wrighton SA.
    Drug Metab Dispos; 2002 Mar 15; 30(3):319-23. PubMed ID: 11854152
    [Abstract] [Full Text] [Related]

  • 8. Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes.
    Lim HK, Duczak N, Brougham L, Elliot M, Patel K, Chan K.
    Drug Metab Dispos; 2005 Aug 15; 33(8):1211-9. PubMed ID: 15860655
    [Abstract] [Full Text] [Related]

  • 9. The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450 mediated biotransformation.
    Duarte MP, Palma BB, Gilep AA, Laires A, Oliveira JS, Usanov SA, Rueff J, Kranendonk M.
    Mutagenesis; 2005 Mar 15; 20(2):93-100. PubMed ID: 15728263
    [Abstract] [Full Text] [Related]

  • 10. Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil.
    Hyland R, Roe EG, Jones BC, Smith DA.
    Br J Clin Pharmacol; 2001 Mar 15; 51(3):239-48. PubMed ID: 11298070
    [Abstract] [Full Text] [Related]

  • 11. Activation of phenacetin O-deethylase activity by alpha-naphthoflavone in human liver microsomes.
    Nakajima M, Kobayashi K, Oshima K, Shimada N, Tokudome S, Chiba K, Yokoi T.
    Xenobiotica; 1999 Sep 15; 29(9):885-98. PubMed ID: 10548449
    [Abstract] [Full Text] [Related]

  • 12. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.
    Kazui M, Nishiya Y, Ishizuka T, Hagihara K, Farid NA, Okazaki O, Ikeda T, Kurihara A.
    Drug Metab Dispos; 2010 Jan 15; 38(1):92-9. PubMed ID: 19812348
    [Abstract] [Full Text] [Related]

  • 13. Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver microsomes.
    Rochat B, Amey M, Gillet M, Meyer UA, Baumann P.
    Pharmacogenetics; 1997 Feb 15; 7(1):1-10. PubMed ID: 9110356
    [Abstract] [Full Text] [Related]

  • 14. In vitro inhibition of human cytochrome P450 enzymes by the novel atypical antipsychotic drug asenapine: a prediction of possible drug-drug interactions.
    Wójcikowski J, Danek PJ, Basińska-Ziobroń A, Pukło R, Daniel WA.
    Pharmacol Rep; 2020 Jun 15; 72(3):612-621. PubMed ID: 32219694
    [Abstract] [Full Text] [Related]

  • 15. Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition.
    Sahi J, Black CB, Hamilton GA, Zheng X, Jolley S, Rose KA, Gilbert D, LeCluyse EL, Sinz MW.
    Drug Metab Dispos; 2003 Apr 15; 31(4):439-46. PubMed ID: 12642470
    [Abstract] [Full Text] [Related]

  • 16. Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs.
    Nakajima M, Nakamura S, Tokudome S, Shimada N, Yamazaki H, Yokoi T.
    Drug Metab Dispos; 1999 Dec 15; 27(12):1381-91. PubMed ID: 10570018
    [Abstract] [Full Text] [Related]

  • 17. Metabolism of tauromustine in liver and lung microsomes from various species.
    Tuvesson H, Gunnarsson PO, Seidegård J.
    Xenobiotica; 1999 Aug 15; 29(8):783-92. PubMed ID: 10553719
    [Abstract] [Full Text] [Related]

  • 18. Dehydrogenation of indoline by cytochrome P450 enzymes: a novel "aromatase" process.
    Sun H, Ehlhardt WJ, Kulanthaivel P, Lanza DL, Reilly CA, Yost GS.
    J Pharmacol Exp Ther; 2007 Aug 15; 322(2):843-51. PubMed ID: 17502430
    [Abstract] [Full Text] [Related]

  • 19. Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: impact on prediction of first-pass metabolism.
    Galetin A, Houston JB.
    J Pharmacol Exp Ther; 2006 Sep 15; 318(3):1220-9. PubMed ID: 16763093
    [Abstract] [Full Text] [Related]

  • 20. Construction of Salmonella typhimurium YG7108 strains, each coexpressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase.
    Fujita K, Nakayama K, Yamazaki Y, Tsuruma K, Yamada M, Nohmi T, Kamataki T.
    Environ Mol Mutagen; 2001 Sep 15; 38(4):329-38. PubMed ID: 11774365
    [Abstract] [Full Text] [Related]

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