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581 related items for PubMed ID: 17910471

  • 1. Sequence recognition in the minor groove of DNA by covalently linked formamido imidazole-pyrrole-imidazole polyamides: effect of H-pin linkage and linker length on selectivity and affinity.
    O'Hare CC, Uthe P, Mackay H, Blackmon K, Jones J, Brown T, Nguyen B, Wilson WD, Lee M, Hartley JA.
    Biochemistry; 2007 Oct 23; 46(42):11661-70. PubMed ID: 17910471
    [Abstract] [Full Text] [Related]

  • 2. Effects of the N-terminal acylamido group of imidazole- and pyrrole-containing polyamides on DNA sequence specificity and binding affinity.
    Westrate L, Mackay H, Brown T, Nguyen B, Kluza J, Wilson WD, Lee M, Hartley JA.
    Biochemistry; 2009 Jun 23; 48(24):5679-88. PubMed ID: 19419200
    [Abstract] [Full Text] [Related]

  • 3. Physical and structural basis for the strong interactions of the -ImPy- central pairing motif in the polyamide f-ImPyIm.
    Buchmueller KL, Bailey SL, Matthews DA, Taherbhai ZT, Register JK, Davis ZS, Bruce CD, O'Hare C, Hartley JA, Lee M.
    Biochemistry; 2006 Nov 14; 45(45):13551-65. PubMed ID: 17087509
    [Abstract] [Full Text] [Related]

  • 4. Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studies.
    Mackay H, Brown T, Uthe PB, Westrate L, Sielaff A, Jones J, Lajiness JP, Kluza J, O'Hare C, Nguyen B, Davis Z, Bruce C, Wilson WD, Hartley JA, Lee M.
    Bioorg Med Chem; 2008 Oct 15; 16(20):9145-53. PubMed ID: 18819814
    [Abstract] [Full Text] [Related]

  • 5. Extending the language of DNA molecular recognition by polyamides: unexpected influence of imidazole and pyrrole arrangement on binding affinity and specificity.
    Buchmueller KL, Staples AM, Howard CM, Horick SM, Uthe PB, Le NM, Cox KK, Nguyen B, Pacheco KA, Wilson WD, Lee M.
    J Am Chem Soc; 2005 Jan 19; 127(2):742-50. PubMed ID: 15643900
    [Abstract] [Full Text] [Related]

  • 6. Modifying the N-terminus of polyamides: PyImPyIm has improved sequence specificity over f-ImPyIm.
    Brown T, Mackay H, Turlington M, Sutterfield A, Smith T, Sielaff A, Westrate L, Bruce C, Kluza J, O'Hare C, Nguyen B, Wilson WD, Hartley JA, Lee M.
    Bioorg Med Chem; 2008 May 01; 16(9):5266-76. PubMed ID: 18353654
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin.
    Brown T, Taherbhai Z, Sexton J, Sutterfield A, Turlington M, Jones J, Stallings L, Stewart M, Buchmueller K, Mackay H, O'hare C, Kluza J, Nguyen B, Wilson D, Lee M, Hartley JA.
    Bioorg Med Chem; 2007 Jan 01; 15(1):474-83. PubMed ID: 17035029
    [Abstract] [Full Text] [Related]

  • 8. Molecular recognition of DNA base pairs by the formamido/pyrrole and formamido/imidazole pairings in stacked polyamides.
    Buchmueller KL, Staples AM, Uthe PB, Howard CM, Pacheco KA, Cox KK, Henry JA, Bailey SL, Horick SM, Nguyen B, Wilson WD, Lee M.
    Nucleic Acids Res; 2005 Jan 01; 33(3):912-21. PubMed ID: 15703305
    [Abstract] [Full Text] [Related]

  • 9. Targeting the inverted CCAAT box 2 in the topoisomerase IIalpha promoter by JH-37, an imidazole-pyrrole polyamide hairpin: design, synthesis, molecular biology, and biophysical studies.
    Henry JA, Le NM, Nguyen B, Howard CM, Bailey SL, Horick SM, Buchmueller KL, Kotecha M, Hochhauser D, Hartley JA, Wilson WD, Lee M.
    Biochemistry; 2004 Sep 28; 43(38):12249-57. PubMed ID: 15379563
    [Abstract] [Full Text] [Related]

  • 10. Novel diamino imidazole and pyrrole-containing polyamides: Synthesis and DNA binding studies of mono- and diamino-phenyl-ImPy*Im polyamides designed to target 5'-ACGCGT-3'.
    Satam V, Babu B, Chavda S, Savagian M, Sjoholm R, Tzou S, Ramos J, Liu Y, Kiakos K, Lin S, David Wilson W, Hartley JA, Lee M.
    Bioorg Med Chem; 2012 Jan 15; 20(2):693-701. PubMed ID: 22222156
    [Abstract] [Full Text] [Related]

  • 11. Dynamic hydrogen bonding and DNA flexibility in minor groove binders: molecular dynamics simulation of the polyamide f-ImPyIm bound to the Mlu1 (MCB) sequence 5'-ACGCGT-3' in 2:1 motif.
    Bruce CD, Ferrara MM, Manka JL, Davis ZS, Register J.
    J Mol Recognit; 2015 May 15; 28(5):325-37. PubMed ID: 25711379
    [Abstract] [Full Text] [Related]

  • 12. Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides.
    Chavda S, Babu B, Patil P, Plaunt A, Ferguson A, Lee M, Tzou S, Sjoholm R, Rice T, Mackay H, Ramos J, Wang S, Lin S, Kiakos K, Wilson WD, Hartley JA, Lee M.
    Bioorg Med Chem; 2013 Jul 01; 21(13):3907-18. PubMed ID: 23647824
    [Abstract] [Full Text] [Related]

  • 13. Setting anchor in the minor groove: in silico investigation into formamido N-methylpyrrole and N-methylimidazole polyamides bound by cognate DNA sequences.
    Collar CJ, Lee M, Wilson WD.
    J Chem Inf Model; 2010 Sep 27; 50(9):1611-22. PubMed ID: 20804157
    [Abstract] [Full Text] [Related]

  • 14. DNA sequence recognition by bispyrazinonaphthalimides antitumor agents.
    Carrasco C, Joubert A, Tardy C, Maestre N, Cacho M, Braña MF, Bailly C.
    Biochemistry; 2003 Oct 14; 42(40):11751-61. PubMed ID: 14529286
    [Abstract] [Full Text] [Related]

  • 15. Effects of the A.T/T.A degeneracy of pyrrole--imidazole polyamide recognition in the minor groove of DNA.
    White S, Baird EE, Dervan PB.
    Biochemistry; 1996 Sep 24; 35(38):12532-7. PubMed ID: 8823190
    [Abstract] [Full Text] [Related]

  • 16. Parallel synthesis of H-pin polyamides by alkene metathesis on solid phase.
    Olenyuk B, Jitianu C, Dervan PB.
    J Am Chem Soc; 2003 Apr 23; 125(16):4741-51. PubMed ID: 12696892
    [Abstract] [Full Text] [Related]

  • 17. The thermodynamics of polyamide-DNA recognition: hairpin polyamide binding in the minor groove of duplex DNA.
    Pilch DS, Poklar N, Baird EE, Dervan PB, Breslauer KJ.
    Biochemistry; 1999 Feb 16; 38(7):2143-51. PubMed ID: 10026298
    [Abstract] [Full Text] [Related]

  • 18. Design, synthesis and DNA binding properties of orthogonally positioned diamino containing polyamide f-IPI.
    Babu B, Liu Y, Plaunt A, Riddering C, Ogilvie R, Westrate L, Davis R, Ferguson A, Mackay H, Rice T, Chavda S, Wilson D, Lin S, Kiakos K, Hartley JA, Lee M.
    Biochem Biophys Res Commun; 2011 Jan 21; 404(3):848-52. PubMed ID: 21185262
    [Abstract] [Full Text] [Related]

  • 19. Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides.
    Gottesfeld JM, Melander C, Suto RK, Raviol H, Luger K, Dervan PB.
    J Mol Biol; 2001 Jun 08; 309(3):615-29. PubMed ID: 11397084
    [Abstract] [Full Text] [Related]

  • 20. Discrimination of hairpin polyamides with an alpha-substituted-gamma-aminobutyric acid as a 5'-TG-3' reader in DNA minor groove.
    Zhang W, Bando T, Sugiyama H.
    J Am Chem Soc; 2006 Jul 12; 128(27):8766-76. PubMed ID: 16819870
    [Abstract] [Full Text] [Related]

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