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Journal Abstract Search

424 related items for PubMed ID: 17938582

  • 41. Structural basis of how stress-induced MDMX phosphorylation activates p53.
    Chen X, Gohain N, Zhan C, Lu WY, Pazgier M, Lu W.
    Oncogene; 2016 Apr 14; 35(15):1919-25. PubMed ID: 26148237
    [Abstract] [Full Text] [Related]

  • 42. Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.
    Nomura K, Klejnot M, Kowalczyk D, Hock AK, Sibbet GJ, Vousden KH, Huang DT.
    Nat Struct Mol Biol; 2017 Jul 14; 24(7):578-587. PubMed ID: 28553961
    [Abstract] [Full Text] [Related]

  • 43. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
    Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA.
    Science; 2004 Feb 06; 303(5659):844-8. PubMed ID: 14704432
    [Abstract] [Full Text] [Related]

  • 44. Peptide activators of the p53 tumor suppressor.
    Zhan C, Lu W.
    Curr Pharm Des; 2011 Feb 06; 17(6):603-9. PubMed ID: 21391910
    [Abstract] [Full Text] [Related]

  • 45. Ensemble-based virtual screening reveals dual-inhibitors for the p53-MDM2/MDMX interactions.
    Barakat K, Mane J, Friesen D, Tuszynski J.
    J Mol Graph Model; 2010 Feb 26; 28(6):555-68. PubMed ID: 20056466
    [Abstract] [Full Text] [Related]

  • 46. MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.
    Wang X, Wang J, Jiang X.
    J Biol Chem; 2011 Jul 08; 286(27):23725-34. PubMed ID: 21572037
    [Abstract] [Full Text] [Related]

  • 47. A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.
    Surmiak E, Twarda-Clapa A, Zak KM, Musielak B, Tomala MD, Kubica K, Grudnik P, Madej M, Jablonski M, Potempa J, Kalinowska-Tluscik J, Dömling A, Dubin G, Holak TA.
    ACS Chem Biol; 2016 Dec 16; 11(12):3310-3318. PubMed ID: 27709883
    [Abstract] [Full Text] [Related]

  • 48. The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization.
    Leslie PL, Ke H, Zhang Y.
    J Biol Chem; 2015 May 15; 290(20):12941-50. PubMed ID: 25809483
    [Abstract] [Full Text] [Related]

  • 49. Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes.
    Kallen J, Goepfert A, Blechschmidt A, Izaac A, Geiser M, Tavares G, Ramage P, Furet P, Masuya K, Lisztwan J.
    J Biol Chem; 2009 Mar 27; 284(13):8812-21. PubMed ID: 19153082
    [Abstract] [Full Text] [Related]

  • 50. Discovery, synthesis, and biological evaluation of orally active pyrrolidone derivatives as novel inhibitors of p53-MDM2 protein-protein interaction.
    Zhuang C, Miao Z, Zhu L, Dong G, Guo Z, Wang S, Zhang Y, Wu Y, Yao J, Sheng C, Zhang W.
    J Med Chem; 2012 Nov 26; 55(22):9630-42. PubMed ID: 23046248
    [Abstract] [Full Text] [Related]

  • 51. Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE.
    Gerarduzzi C, de Polo A, Liu XS, El Kharbili M, Little JB, Yuan ZM.
    J Biol Chem; 2016 Dec 09; 291(50):25937-25949. PubMed ID: 27777309
    [Abstract] [Full Text] [Related]

  • 52. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
    Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine AJ, Pavletich NP.
    Science; 1996 Nov 08; 274(5289):948-53. PubMed ID: 8875929
    [Abstract] [Full Text] [Related]

  • 53. Novel simplified yeast-based assays of regulators of p53-MDMX interaction and p53 transcriptional activity.
    Leão M, Gomes S, Soares J, Bessa C, Maciel C, Ciribilli Y, Pereira C, Inga A, Saraiva L.
    FEBS J; 2013 Dec 08; 280(24):6498-507. PubMed ID: 24119020
    [Abstract] [Full Text] [Related]

  • 54. MDM2 interacts with MDMX through their RING finger domains.
    Tanimura S, Ohtsuka S, Mitsui K, Shirouzu K, Yoshimura A, Ohtsubo M.
    FEBS Lett; 1999 Mar 19; 447(1):5-9. PubMed ID: 10218570
    [Abstract] [Full Text] [Related]

  • 55. Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase.
    Okamoto K, Taya Y, Nakagama H.
    FEBS Lett; 2009 Sep 03; 583(17):2710-4. PubMed ID: 19619542
    [Abstract] [Full Text] [Related]

  • 56. Use of a retroinverso p53 peptide as an inhibitor of MDM2.
    Sakurai K, Chung HS, Kahne D.
    J Am Chem Soc; 2004 Dec 22; 126(50):16288-9. PubMed ID: 15600307
    [Abstract] [Full Text] [Related]

  • 57. Regulation of p53: a collaboration between Mdm2 and Mdmx.
    Pei D, Zhang Y, Zheng J.
    Oncotarget; 2012 Mar 22; 3(3):228-35. PubMed ID: 22410433
    [Abstract] [Full Text] [Related]

  • 58. Design of a novel MDM2 binding peptide based on the p53 family.
    Madhumalar A, Lee HJ, Brown CJ, Lane D, Verma C.
    Cell Cycle; 2009 Sep 01; 8(17):2828-36. PubMed ID: 19713735
    [Abstract] [Full Text] [Related]

  • 59. Targeting the conformational transitions of MDM2 and MDMX: insights into dissimilarities and similarities of p53 recognition.
    Macchiarulo A, Giacchè N, Carotti A, Baroni M, Cruciani G, Pellicciari R.
    J Chem Inf Model; 2008 Oct 01; 48(10):1999-2009. PubMed ID: 18826207
    [Abstract] [Full Text] [Related]

  • 60. Effect of the Flexible Regions of the Oncoprotein Mouse Double Minute X on Inhibitor Binding Affinity.
    Qin L, Liu H, Chen R, Zhou J, Cheng X, Chen Y, Huang Y, Su Z.
    Biochemistry; 2017 Nov 07; 56(44):5943-5954. PubMed ID: 29023092
    [Abstract] [Full Text] [Related]

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