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Journal Abstract Search

164 related items for PubMed ID: 17998163

  • 1. N-Phenyl-N'-(2-chloroethyl)ureas (CEUs) as potential antineoplastic agents. Part 3: role of carbonyl groups in the covalent binding to the colchicine-binding site.
    Moreau E, Fortin S, Lacroix J, Patenaude A, Rousseau JL, C-Gaudreault R.
    Bioorg Med Chem; 2008 Feb 01; 16(3):1206-17. PubMed ID: 17998163
    [Abstract] [Full Text] [Related]

  • 2. Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site.
    Fortin JS, Lacroix J, Desjardins M, Patenaude A, Petitclerc E, C-Gaudreault R.
    Bioorg Med Chem; 2007 Jul 01; 15(13):4456-69. PubMed ID: 17498960
    [Abstract] [Full Text] [Related]

  • 3. N-Phenyl-N'-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: role of omega-hydroxyl group in the covalent binding to beta-tubulin.
    Fortin S, Moreau E, Patenaude A, Desjardins M, Lacroix J, Rousseau JL, C-Gaudreault R.
    Bioorg Med Chem; 2007 Feb 01; 15(3):1430-8. PubMed ID: 17118664
    [Abstract] [Full Text] [Related]

  • 4. Synthesis, antiproliferative activity evaluation and structure-activity relationships of novel aromatic urea and amide analogues of N-phenyl-N'-(2-chloroethyl)ureas.
    Fortin S, Moreau E, Lacroix J, Côté MF, Petitclerc E, C-Gaudreault R.
    Eur J Med Chem; 2010 Jul 01; 45(7):2928-37. PubMed ID: 20400211
    [Abstract] [Full Text] [Related]

  • 5. Mechanism of action of N-phenyl-N'-(2-chloroethyl)ureas in the colchicine-binding site at the interface between alpha- and beta-tubulin.
    Fortin S, Wei L, Moreau E, Labrie P, Petitclerc E, Kotra LP, C-Gaudreault R.
    Bioorg Med Chem; 2009 May 15; 17(10):3690-7. PubMed ID: 19398206
    [Abstract] [Full Text] [Related]

  • 6. Selective alkylation of beta(II)-tubulin and thioredoxin-1 by structurally related subsets of aryl chloroethylureas leading to either anti-microtubules or redox modulating agents.
    Fortin JS, Côté MF, Lacroix J, Desjardins M, Petitclerc E, C-Gaudreault R.
    Bioorg Med Chem; 2008 Aug 01; 16(15):7277-90. PubMed ID: 18617414
    [Abstract] [Full Text] [Related]

  • 7. Characterization of the covalent binding of N-phenyl-N'-(2-chloroethyl)ureas to {beta}-tubulin: importance of Glu198 in microtubule stability.
    Fortin S, Bouchon B, Chambon C, Lacroix J, Moreau E, Chezal JM, Degoul F, C-Gaudreault R.
    J Pharmacol Exp Ther; 2011 Feb 01; 336(2):460-7. PubMed ID: 20978170
    [Abstract] [Full Text] [Related]

  • 8. Optimized N-phenyl-N'-(2-chloroethyl)ureas as potential antineoplastic agents: synthesis and growth inhibition activity.
    Moreau E, Fortin S, Desjardins M, Rousseau JL, Petitclerc E, C-Gaudreault R.
    Bioorg Med Chem; 2005 Dec 15; 13(24):6703-12. PubMed ID: 16165366
    [Abstract] [Full Text] [Related]

  • 9. Aromatic 2-chloroethyl urea derivatives and bioisosteres. Part 2: Cytocidal activity and effects on the nuclear translocation of thioredoxin-1, and the cell cycle progression.
    Fortin JS, Côté MF, Lacroix J, Petitclerc E, C-Gaudreault R.
    Bioorg Med Chem; 2008 Aug 01; 16(15):7477-88. PubMed ID: 18579387
    [Abstract] [Full Text] [Related]

  • 10. N-Phenyl-N'-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N'-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?
    Fortin S, Moreau E, Lacroix J, Teulade JC, Patenaude A, C-Gaudreault R.
    Bioorg Med Chem Lett; 2007 Apr 01; 17(7):2000-4. PubMed ID: 17291753
    [Abstract] [Full Text] [Related]

  • 11. Alkylation of prohibitin by cyclohexylphenyl-chloroethyl urea on an aspartyl residue is associated with cell cycle G(1) arrest in B16 cells.
    Bouchon B, Papon J, Communal Y, Madelmont JC, Degoul F.
    Br J Pharmacol; 2007 Oct 01; 152(4):449-55. PubMed ID: 17704829
    [Abstract] [Full Text] [Related]

  • 12. A comparative molecular field and comparative molecular similarity indices analyses (CoMFA and CoMSIA) of N-phenyl-N'-(2-chloroethyl)ureas targeting the colchicine-binding site as anticancer agents.
    Fortin S, Labrie P, Moreau E, Wei L, Kotra LP, C-Gaudreault R.
    Bioorg Med Chem; 2008 Feb 15; 16(4):1914-26. PubMed ID: 18023585
    [Abstract] [Full Text] [Related]

  • 13. Microtubule disruption induced in vivo by alkylation of beta-tubulin by 1-aryl-3-(2-chloroethyl)ureas, a novel class of soft alkylating agents.
    Legault J, Gaulin JF, Mounetou E, Bolduc S, Lacroix J, Poyet P, Gaudreault RC.
    Cancer Res; 2000 Feb 15; 60(4):985-92. PubMed ID: 10706114
    [Abstract] [Full Text] [Related]

  • 14. Antiangiogenic and antitumoral activity of phenyl-3-(2-chloroethyl)ureas: a class of soft alkylating agents disrupting microtubules that are unaffected by cell adhesion-mediated drug resistance.
    Petitclerc E, Deschesnes RG, Côté MF, Marquis C, Janvier R, Lacroix J, Miot-Noirault E, Legault J, Mounetou E, Madelmont JC, C -Gaudreault R.
    Cancer Res; 2004 Jul 01; 64(13):4654-63. PubMed ID: 15231678
    [Abstract] [Full Text] [Related]

  • 15. Intramolecular cyclization of N-phenyl N'(2-chloroethyl)ureas leads to active N-phenyl-4,5-dihydrooxazol-2-amines alkylating β-tubulin Glu198 and prohibitin Asp40.
    Trzeciakiewicz A, Fortin S, Moreau E, C-Gaudreault R, Lacroix J, Chambon C, Communal Y, Chezal JM, Miot-Noirault E, Bouchon B, Degoul F.
    Biochem Pharmacol; 2011 May 01; 81(9):1116-23. PubMed ID: 21371445
    [Abstract] [Full Text] [Related]

  • 16. Styryl-N-phenyl-N'-(2-chloroethyl)ureas and styrylphenylimidazolidin-2-ones as new potent microtubule-disrupting agents using combretastatin A-4 as model.
    Gagné-Boulet M, Fortin S, Lacroix J, Lefebvre CA, Côté MF, C-Gaudreault R.
    Eur J Med Chem; 2015 Jul 15; 100():34-43. PubMed ID: 26069928
    [Abstract] [Full Text] [Related]

  • 17. Design, synthesis, and biological evaluation of thiophene analogues of chalcones.
    Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Cruz-Lopez O, Preti D, Tolomeo M, Grimaudo S, Di Cristina A, Zonta N, Balzarini J, Brancale A, Sarkar T, Hamel E.
    Bioorg Med Chem; 2008 May 15; 16(10):5367-76. PubMed ID: 18440234
    [Abstract] [Full Text] [Related]

  • 18. A new generation of N-aryl-N'-(1-alkyl-2-chloroethyl)ureas as microtubule disrupters: synthesis, antiproliferative activity, and beta-tubulin alkylation kinetics.
    Mounetou E, Legault J, Lacroix J, C -Gaudreault R.
    J Med Chem; 2003 Nov 06; 46(23):5055-63. PubMed ID: 14584955
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.
    Romagnoli R, Baraldi PG, Pavani MG, Tabrizi MA, Preti D, Fruttarolo F, Piccagli L, Jung MK, Hamel E, Borgatti M, Gambari R.
    J Med Chem; 2006 Jun 29; 49(13):3906-15. PubMed ID: 16789746
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and anticancer activity of N-bis(trifluoromethyl)alkyl-N'-thiazolyl and N-bis(trifluoromethyl)alkyl-N'-benzothiazolyl ureas.
    Luzina EL, Popov AV.
    Eur J Med Chem; 2009 Dec 29; 44(12):4944-53. PubMed ID: 19740574
    [Abstract] [Full Text] [Related]

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