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Journal Abstract Search

113 related items for PubMed ID: 18020309

  • 1. Derrubone, an inhibitor of the Hsp90 protein folding machinery.
    Hadden MK, Galam L, Gestwicki JE, Matts RL, Blagg BS.
    J Nat Prod; 2007 Dec; 70(12):2014-8. PubMed ID: 18020309
    [Abstract] [Full Text] [Related]

  • 2. Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation.
    Blagg BS, Kerr TD.
    Med Res Rev; 2006 May; 26(3):310-38. PubMed ID: 16385472
    [Abstract] [Full Text] [Related]

  • 3. Hsp90 inhibitors identified from a library of novobiocin analogues.
    Yu XM, Shen G, Neckers L, Blake H, Holzbeierlein J, Cronk B, Blagg BS.
    J Am Chem Soc; 2005 Sep 21; 127(37):12778-9. PubMed ID: 16159253
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and evaluation of derrubone and select analogues.
    Hastings JM, Hadden MK, Blagg BS.
    J Org Chem; 2008 Jan 18; 73(2):369-73. PubMed ID: 18154304
    [Abstract] [Full Text] [Related]

  • 5. Discovery and biological activity of 6BrCaQ as an inhibitor of the Hsp90 protein folding machinery.
    Audisio D, Messaoudi S, Cegielkowski L, Peyrat JF, Brion JD, Methy-Gonnot D, Radanyi C, Renoir JM, Alami M.
    ChemMedChem; 2011 May 02; 6(5):804-15. PubMed ID: 21374821
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and evaluation of coumermycin A1 analogues that inhibit the Hsp90 protein folding machinery.
    Burlison JA, Blagg BS.
    Org Lett; 2006 Oct 12; 8(21):4855-8. PubMed ID: 17020320
    [Abstract] [Full Text] [Related]

  • 7. The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone.
    Mays JR, Hill SA, Moyers JT, Blagg BS.
    Bioorg Med Chem; 2010 Jan 01; 18(1):249-66. PubMed ID: 19932969
    [Abstract] [Full Text] [Related]

  • 8. Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.
    He H, Zatorska D, Kim J, Aguirre J, Llauger L, She Y, Wu N, Immormino RM, Gewirth DT, Chiosis G.
    J Med Chem; 2006 Jan 12; 49(1):381-90. PubMed ID: 16392823
    [Abstract] [Full Text] [Related]

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  • 11. Inside the Hsp90 inhibitors binding mode through induced fit docking.
    Lauria A, Ippolito M, Almerico AM.
    J Mol Graph Model; 2009 Feb 12; 27(6):712-22. PubMed ID: 19084447
    [Abstract] [Full Text] [Related]

  • 12. The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.
    Cheung KM, Matthews TP, James K, Rowlands MG, Boxall KJ, Sharp SY, Maloney A, Roe SM, Prodromou C, Pearl LH, Aherne GW, McDonald E, Workman P.
    Bioorg Med Chem Lett; 2005 Jul 15; 15(14):3338-43. PubMed ID: 15955698
    [Abstract] [Full Text] [Related]

  • 13. Identification and initial SAR of silybin: an Hsp90 inhibitor.
    Zhao H, Brandt GE, Galam L, Matts RL, Blagg BS.
    Bioorg Med Chem Lett; 2011 May 01; 21(9):2659-64. PubMed ID: 21273068
    [Abstract] [Full Text] [Related]

  • 14. Molecular characterization of macbecin as an Hsp90 inhibitor.
    Martin CJ, Gaisser S, Challis IR, Carletti I, Wilkinson B, Gregory M, Prodromou C, Roe SM, Pearl LH, Boyd SM, Zhang MQ.
    J Med Chem; 2008 May 08; 51(9):2853-7. PubMed ID: 18357975
    [Abstract] [Full Text] [Related]

  • 15. High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase.
    Galam L, Hadden MK, Ma Z, Ye QZ, Yun BG, Blagg BS, Matts RL.
    Bioorg Med Chem; 2007 Mar 01; 15(5):1939-46. PubMed ID: 17223347
    [Abstract] [Full Text] [Related]

  • 16. Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90.
    Barta TE, Veal JM, Rice JW, Partridge JM, Fadden RP, Ma W, Jenks M, Geng L, Hanson GJ, Huang KH, Barabasz AF, Foley BE, Otto J, Hall SE.
    Bioorg Med Chem Lett; 2008 Jun 15; 18(12):3517-21. PubMed ID: 18511277
    [Abstract] [Full Text] [Related]

  • 17. Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity.
    Böll B, Eltaib F, Reiners KS, von Tresckow B, Tawadros S, Simhadri VR, Burrows FJ, Lundgren K, Hansen HP, Engert A, von Strandmann EP.
    Clin Cancer Res; 2009 Aug 15; 15(16):5108-16. PubMed ID: 19671844
    [Abstract] [Full Text] [Related]

  • 18. Inhibition of cancer invasion and metastasis by targeting the molecular chaperone heat-shock protein 90.
    Koga F, Kihara K, Neckers L.
    Anticancer Res; 2009 Mar 15; 29(3):797-807. PubMed ID: 19414312
    [Abstract] [Full Text] [Related]

  • 19. Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
    Huth JR, Park C, Petros AM, Kunzer AR, Wendt MD, Wang X, Lynch CL, Mack JC, Swift KM, Judge RA, Chen J, Richardson PL, Jin S, Tahir SK, Matayoshi ED, Dorwin SA, Ladror US, Severin JM, Walter KA, Bartley DM, Fesik SW, Elmore SW, Hajduk PJ.
    Chem Biol Drug Des; 2007 Jul 15; 70(1):1-12. PubMed ID: 17630989
    [Abstract] [Full Text] [Related]

  • 20. Evaluation of the Hsp90 inhibitor NVP-AUY922 in multicellular tumour spheroids with respect to effects on growth and PET tracer uptake.
    Monazzam A, Razifar P, Ide S, Rugaard Jensen M, Josephsson R, Blomqvist C, Langström B, Bergström M.
    Nucl Med Biol; 2009 Apr 15; 36(3):335-42. PubMed ID: 19324279
    [Abstract] [Full Text] [Related]

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