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Journal Abstract Search

202 related items for PubMed ID: 18020391

  • 1. From astemizole to a novel hit series of small-molecule somatostatin 5 receptor antagonists via GPCR affinity profiling.
    Guba W, Green LG, Martin RE, Roche O, Kratochwil N, Mauser H, Bissantz C, Christ A, Stahl M.
    J Med Chem; 2007 Dec 13; 50(25):6295-8. PubMed ID: 18020391
    [Abstract] [Full Text] [Related]

  • 2. Discovery of the first nonpeptidic, small-molecule, highly selective somatostatin receptor subtype 5 antagonists: a chemogenomics approach.
    Martin RE, Green LG, Guba W, Kratochwil N, Christ A.
    J Med Chem; 2007 Dec 13; 50(25):6291-4. PubMed ID: 18020390
    [Abstract] [Full Text] [Related]

  • 3. Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists.
    Suzuki T, Moriya M, Sakamoto T, Suga T, Kishino H, Takahashi H, Ishikawa M, Nagai K, Imai Y, Sekino E, Ito M, Iwaasa H, Ishihara A, Tokita S, Kanatani A, Sato N, Fukami T.
    Bioorg Med Chem Lett; 2009 Jun 01; 19(11):3072-7. PubMed ID: 19403308
    [Abstract] [Full Text] [Related]

  • 4. Recognition of privileged structures by G-protein coupled receptors.
    Bondensgaard K, Ankersen M, Thøgersen H, Hansen BS, Wulff BS, Bywater RP.
    J Med Chem; 2004 Feb 12; 47(4):888-99. PubMed ID: 14761190
    [Abstract] [Full Text] [Related]

  • 5. Discovery and SAR of biaryl piperidine MCH1 receptor antagonists through solid-phase encoded combinatorial synthesis.
    Guo T, Shao Y, Qian G, Rokosz LL, Stauffer TM, Hunter RC, Babu SD, Gu H, Hobbs DW.
    Bioorg Med Chem Lett; 2005 Aug 15; 15(16):3696-700. PubMed ID: 15978811
    [Abstract] [Full Text] [Related]

  • 6. Pharmacological profile of astemizole-derived compounds at the histamine H1 and H4 receptor--H1/H4 receptor selectivity.
    Wagner E, Wittmann HJ, Elz S, Strasser A.
    Naunyn Schmiedebergs Arch Pharmacol; 2014 Mar 15; 387(3):235-50. PubMed ID: 24241585
    [Abstract] [Full Text] [Related]

  • 7. G-protein-coupled receptor affinity prediction based on the use of a profiling dataset: QSAR design, synthesis, and experimental validation.
    Rolland C, Gozalbes R, Nicolaï E, Paugam MF, Coussy L, Barbosa F, Horvath D, Revah F.
    J Med Chem; 2005 Oct 20; 48(21):6563-74. PubMed ID: 16220973
    [Abstract] [Full Text] [Related]

  • 8. Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening.
    Cavasotto CN, Orry AJ, Murgolo NJ, Czarniecki MF, Kocsi SA, Hawes BE, O'Neill KA, Hine H, Burton MS, Voigt JH, Abagyan RA, Bayne ML, Monsma FJ.
    J Med Chem; 2008 Feb 14; 51(3):581-8. PubMed ID: 18198821
    [Abstract] [Full Text] [Related]

  • 9. Identification of new potent GPR119 agonists by combining virtual screening and combinatorial chemistry.
    Wellenzohn B, Lessel U, Beller A, Isambert T, Hoenke C, Nosse B.
    J Med Chem; 2012 Dec 27; 55(24):11031-41. PubMed ID: 23211099
    [Abstract] [Full Text] [Related]

  • 10. G-protein-coupled receptor-focused drug discovery using a target class platform approach.
    Heilker R, Wolff M, Tautermann CS, Bieler M.
    Drug Discov Today; 2009 Mar 27; 14(5-6):231-40. PubMed ID: 19121411
    [Abstract] [Full Text] [Related]

  • 11. Identification of substituted 4-aminopiperidines and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity.
    Kim N, Meyers KM, Mendez-Andino JL, Warshakoon NC, Ji W, Wos JA, Colson A, Mitchell MC, Davis JR, Pinney BB, Reizes O, Hu XE.
    Bioorg Med Chem Lett; 2006 Oct 15; 16(20):5445-50. PubMed ID: 16879961
    [Abstract] [Full Text] [Related]

  • 12. 2-Aminomethyl piperidines as novel urotensin-II receptor antagonists.
    Jin J, Wang Y, Wang F, Shi D, Erhard KF, Wu Z, Guida BF, Lawrence SK, Behm DJ, Disa J, Vaidya KS, Evans C, McMillan LJ, Rivero RA, Neeb MJ, Douglas SA.
    Bioorg Med Chem Lett; 2008 May 01; 18(9):2860-4. PubMed ID: 18420409
    [Abstract] [Full Text] [Related]

  • 13. Ligand identification for G-protein-coupled receptors: a lead generation perspective.
    Bleicher KH, Green LG, Martin RE, Rogers-Evans M.
    Curr Opin Chem Biol; 2004 Jun 01; 8(3):287-96. PubMed ID: 15183327
    [Abstract] [Full Text] [Related]

  • 14. Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists.
    Martin RE, Mohr P, Maerki HP, Guba W, Kuratli C, Gavelle O, Binggeli A, Bendels S, Alvarez-Sánchez R, Alker A, Polonchuk L, Christ AD.
    Bioorg Med Chem Lett; 2009 Nov 01; 19(21):6106-13. PubMed ID: 19786348
    [Abstract] [Full Text] [Related]

  • 15. Novel CXCR3 antagonists with a piperazinyl-piperidine core.
    McGuinness BF, Carroll CD, Zawacki LG, Dong G, Yang C, Hobbs DW, Jacob-Samuel B, Hall JW, Jenh CH, Kozlowski JA, Anilkumar GN, Rosenblum SB.
    Bioorg Med Chem Lett; 2009 Sep 01; 19(17):5205-8. PubMed ID: 19647429
    [Abstract] [Full Text] [Related]

  • 16. A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor.
    Clark DE, Higgs C, Wren SP, Dyke HJ, Wong M, Norman D, Lockey PM, Roach AG.
    J Med Chem; 2004 Jul 29; 47(16):3962-71. PubMed ID: 15267235
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1).
    Rowbottom MW, Vickers TD, Tamiya J, Zhang M, Dyck B, Grey J, Schwarz D, Heise CE, Hedrick M, Wen J, Tang H, Wang H, Fisher A, Aparicio A, Saunders J, Goodfellow VS.
    Bioorg Med Chem Lett; 2007 Apr 15; 17(8):2171-8. PubMed ID: 17350839
    [Abstract] [Full Text] [Related]

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  • 19. Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2.
    Caldwell JP, Matasi JJ, Fernandez X, McLeod RL, Zhang H, Fawzi A, Tulshian DB.
    Bioorg Med Chem Lett; 2009 Feb 15; 19(4):1164-7. PubMed ID: 19147350
    [Abstract] [Full Text] [Related]

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