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Journal Abstract Search

231 related items for PubMed ID: 18039572

  • 1. Design, synthesis, and biological activity of piperidine diamine derivatives as factor Xa inhibitor.
    Mochizuki A, Nakamoto Y, Naito H, Uoto K, Ohta T.
    Bioorg Med Chem Lett; 2008 Jan 15; 18(2):782-7. PubMed ID: 18039572
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  • 2. Synthesis and biological activity of novel 1,2-disubstituted benzene derivatives as factor Xa inhibitors.
    Koshio H, Hirayama F, Ishihara T, Shiraki R, Shigenaga T, Taniuchi Y, Sato K, Moritani Y, Iwatsuki Y, Kaku S, Katayama N, Kawasaki T, Matsumoto Y, Sakamoto S, Tsukamoto S.
    Bioorg Med Chem; 2005 Feb 15; 13(4):1305-23. PubMed ID: 15670939
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  • 3. Stereoselective synthesis and biological evaluation of 3,4-diaminocyclohexanecarboxylic acid derivatives as factor Xa inhibitors.
    Nagata T, Nagamochi M, Kobayashi S, Komoriya S, Yoshino T, Kanno H.
    Bioorg Med Chem Lett; 2008 Aug 15; 18(16):4587-92. PubMed ID: 18675545
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  • 5. Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors.
    Quan ML, Han Q, Fevig JM, Lam PY, Bai S, Knabb RM, Luettgen JM, Wong PC, Wexler RR.
    Bioorg Med Chem Lett; 2006 Apr 01; 16(7):1795-8. PubMed ID: 16434195
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  • 8. Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors.
    Yoshikawa K, Yoshino T, Yokomizo Y, Uoto K, Naito H, Kawakami K, Mochizuki A, Nagata T, Suzuki M, Kanno H, Takemura M, Ohta T.
    Bioorg Med Chem Lett; 2011 Apr 01; 21(7):2133-40. PubMed ID: 21345673
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  • 9. Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs.
    Young RJ, Borthwick AD, Brown D, Burns-Kurtis CL, Campbell M, Chan C, Charbaut M, Chung CW, Convery MA, Kelly HA, Paul King N, Kleanthous S, Mason AM, Pateman AJ, Patikis AN, Pinto IL, Pollard DR, Senger S, Shah GP, Toomey JR, Watson NS, Weston HE.
    Bioorg Med Chem Lett; 2008 Jan 01; 18(1):23-7. PubMed ID: 18054228
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  • 10. Discovery of an orally efficacious inhibitor of coagulation factor Xa which incorporates a neutral P1 ligand.
    Choi-Sledeski YM, Kearney R, Poli G, Pauls H, Gardner C, Gong Y, Becker M, Davis R, Spada A, Liang G, Chu V, Brown K, Collussi D, Leadley R, Rebello S, Moxey P, Morgan S, Bentley R, Kasiewski C, Maignan S, Guilloteau JP, Mikol V.
    J Med Chem; 2003 Feb 27; 46(5):681-4. PubMed ID: 12593648
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  • 11. Structure-activity relationships of potent and selective factor Xa inhibitors: benzimidazole derivatives with the side chain oriented to the prime site of factor Xa.
    Ueno H, Katoh S, Yokota K, Hoshi J, Hayashi M, Uchida I, Aisaka K, Hase Y, Cho H.
    Bioorg Med Chem Lett; 2004 Aug 16; 14(16):4281-6. PubMed ID: 15261287
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  • 16. Enantiopure five-membered cyclicdiamine derivatives as potent and selective inhibitors of factor Xa. Improving in vitro metabolic stability via core modifications.
    Qiao JX, Wang TC, Wang GZ, Cheney DL, He K, Rendina AR, Xin B, Luettgen JM, Knabb RM, Wexler RR, Lam PY.
    Bioorg Med Chem Lett; 2007 Sep 15; 17(18):5041-8. PubMed ID: 17643988
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  • 17. 7-fluoroindazoles as potent and selective inhibitors of factor Xa.
    Lee YK, Parks DJ, Lu T, Thieu TV, Markotan T, Pan W, McComsey DF, Milkiewicz KL, Crysler CS, Ninan N, Abad MC, Giardino EC, Maryanoff BE, Damiano BP, Player MR.
    J Med Chem; 2008 Jan 24; 51(2):282-97. PubMed ID: 18159923
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  • 19. Synthesis and biological evaluation of the metabolites of 2-(1-{3-[(6-chloronaphthalen-2-yl)sulfonyl]propanoyl}piperidin-4-yl)-5-methyl-1,2-dihydro-3H-imidazo[1,5-c]imidazol-3-one.
    Fujimoto T, Tobisu M, Konishi N, Kawamura M, Tada N, Takagi T, Kubo K.
    Bioorg Med Chem; 2009 Dec 01; 17(23):7993-8002. PubMed ID: 19861238
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