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148 related items for PubMed ID: 18053806

  • 1. A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells.
    Miyata Y, Sato T, Imada K, Dobashi A, Yano M, Ito A.
    Biochem Biophys Res Commun; 2008 Feb 01; 366(1):168-73. PubMed ID: 18053806
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  • 2. Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin.
    Miyata Y, Sato T, Yano M, Ito A.
    Mol Cancer Ther; 2004 Jul 01; 3(7):839-47. PubMed ID: 15252145
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  • 3. Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells.
    Sato T, Koike L, Miyata Y, Hirata M, Mimaki Y, Sashida Y, Yano M, Ito A.
    Cancer Res; 2002 Feb 15; 62(4):1025-9. PubMed ID: 11861377
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  • 4. Antimetastatic effect of nobiletin through the down-regulation of CXC chemokine receptor type 4 and matrix metallopeptidase-9.
    Baek SH, Kim SM, Nam D, Lee JH, Ahn KS, Choi SH, Kim SH, Shim BS, Chang IM, Ahn KS.
    Pharm Biol; 2012 Oct 15; 50(10):1210-8. PubMed ID: 22853317
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  • 6. Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells.
    Eguchi A, Murakami A, Ohigashi H.
    FEBS Lett; 2006 May 29; 580(13):3321-8. PubMed ID: 16698017
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  • 14. 4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.
    Al Rahim M, Nakajima A, Saigusa D, Tetsu N, Maruyama Y, Shibuya M, Yamakoshi H, Tomioka Y, Iwabuchi Y, Ohizumi Y, Yamakuni T.
    Biochemistry; 2009 Aug 18; 48(32):7713-21. PubMed ID: 19601643
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  • 15. Effect of natsudaidain isolated from Citrus plants on TNF-alpha and cyclooxygenase-2 expression in RBL-2H3 cells.
    Matsui T, Ito C, Itoigawa M, Okada T, Furukawa H.
    J Pharm Pharmacol; 2009 Jan 18; 61(1):109-14. PubMed ID: 19126304
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  • 19. The effect of doxorubicin on MEK-ERK signaling predicts its efficacy in HCC.
    Choi J, Yip-Schneider M, Albertin F, Wiesenauer C, Wang Y, Schmidt CM.
    J Surg Res; 2008 Dec 18; 150(2):219-26. PubMed ID: 18468633
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  • 20. Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappaB, AP-1, and Sp1 activation.
    Hirata Y, Masuda Y, Kakutani H, Higuchi T, Takada K, Ito A, Nakagawa Y, Ishii H.
    Biochem Pharmacol; 2008 Apr 01; 75(7):1504-14. PubMed ID: 18261712
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