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Journal Abstract Search

917 related items for PubMed ID: 18083512

  • 1. Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase--structure-activity relationships and crystallographic analysis.
    Kirschberg TA, Balakrishnan M, Huang W, Hluhanich R, Kutty N, Liclican AC, McColl DJ, Squires NH, Lansdon EB.
    Bioorg Med Chem Lett; 2008 Feb 01; 18(3):1131-4. PubMed ID: 18083512
    [Abstract] [Full Text] [Related]

  • 2. Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase.
    Sweeney ZK, Acharya S, Briggs A, Dunn JP, Elworthy TR, Fretland J, Giannetti AM, Heilek G, Li Y, Kaiser AC, Martin M, Saito YD, Smith M, Suh JM, Swallow S, Wu J, Hang JQ, Zhou AS, Klumpp K.
    Bioorg Med Chem Lett; 2008 Aug 01; 18(15):4348-51. PubMed ID: 18625554
    [Abstract] [Full Text] [Related]

  • 3. Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants.
    Su DS, Lim JJ, Tinney E, Wan BL, Young MB, Anderson KD, Rudd D, Munshi V, Bahnck C, Felock PJ, Lu M, Lai MT, Touch S, Moyer G, Distefano DJ, Flynn JA, Liang Y, Sanchez R, Prasad S, Yan Y, Perlow-Poehnelt R, Torrent M, Miller M, Vacca JP, Williams TM, Anthony NJ.
    Bioorg Med Chem Lett; 2009 Sep 01; 19(17):5119-23. PubMed ID: 19631528
    [Abstract] [Full Text] [Related]

  • 4. Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
    Hopkins AL, Ren J, Milton J, Hazen RJ, Chan JH, Stuart DI, Stammers DK.
    J Med Chem; 2004 Nov 18; 47(24):5912-22. PubMed ID: 15537346
    [Abstract] [Full Text] [Related]

  • 5. Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase.
    Sweeney ZK, Harris SF, Arora SF, Javanbakht H, Li Y, Fretland J, Davidson JP, Billedeau JR, Gleason SK, Hirschfeld D, Kennedy-Smith JJ, Mirzadegan T, Roetz R, Smith M, Sperry S, Suh JM, Wu J, Tsing S, Villaseñor AG, Paul A, Su G, Heilek G, Hang JQ, Zhou AS, Jernelius JA, Zhang FJ, Klumpp K.
    J Med Chem; 2008 Dec 11; 51(23):7449-58. PubMed ID: 19007201
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1.
    Wu B, Kuhen K, Ngoc Nguyen T, Ellis D, Anaclerio B, He X, Yang K, Karanewsky D, Yin H, Wolff K, Bieza K, Caldwell J, He Y.
    Bioorg Med Chem Lett; 2006 Jul 01; 16(13):3430-3. PubMed ID: 16632349
    [Abstract] [Full Text] [Related]

  • 7. Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity.
    Heeres J, de Jonge MR, Koymans LM, Daeyaert FF, Vinkers M, Van Aken KJ, Arnold E, Das K, Kilonda A, Hoornaert GJ, Compernolle F, Cegla M, Azzam RA, Andries K, de Béthune MP, Azijn H, Pauwels R, Lewi PJ, Janssen PA.
    J Med Chem; 2005 Mar 24; 48(6):1910-8. PubMed ID: 15771435
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and biological evaluation of N4-(hetero)arylsulfonylquinoxalinones as HIV-1 reverse transcriptase inhibitors.
    Xu B, Sun Y, Guo Y, Cao Y, Yu T.
    Bioorg Med Chem; 2009 Apr 01; 17(7):2767-74. PubMed ID: 19269831
    [Abstract] [Full Text] [Related]

  • 9. Strategies for the design of HIV-1 non-nucleoside reverse transcriptase inhibitors: lessons from the development of seven representative paradigms.
    Li D, Zhan P, De Clercq E, Liu X.
    J Med Chem; 2012 Apr 26; 55(8):3595-613. PubMed ID: 22268494
    [No Abstract] [Full Text] [Related]

  • 10. Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.
    Chan JH, Freeman GA, Tidwell JH, Romines KR, Schaller LT, Cowan JR, Gonzales SS, Lowell GS, Andrews CW, Reynolds DJ, St Clair M, Hazen RJ, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Koszalka GW, Boone LR.
    J Med Chem; 2004 Feb 26; 47(5):1175-82. PubMed ID: 14971897
    [Abstract] [Full Text] [Related]

  • 11. Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 13: synthesis of fluorine-containing diaryltriazine derivatives for in vitro anti-HIV evaluation against wild-type strain.
    Xiong YZ, Chen FE, Balzarini J, De Clercq E, Pannecouque C.
    Chem Biodivers; 2009 Apr 26; 6(4):561-8. PubMed ID: 19353537
    [Abstract] [Full Text] [Related]

  • 12. A 3D QSAR study of a series of HEPT analogues: the influence of conformational mobility on HIV-1 reverse transcriptase inhibition.
    Kireev DB, Chrétien JR, Grierson DS, Monneret C.
    J Med Chem; 1997 Dec 19; 40(26):4257-64. PubMed ID: 9435895
    [Abstract] [Full Text] [Related]

  • 13. Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants.
    Cancio R, Mai A, Rotili D, Artico M, Sbardella G, Clotet-Codina I, Esté JA, Crespan E, Zanoli S, Hübscher U, Spadari S, Maga G.
    ChemMedChem; 2007 Apr 19; 2(4):445-8. PubMed ID: 17323401
    [No Abstract] [Full Text] [Related]

  • 14. Synthesis and biological activity of naphthyl-substituted (B-ring) benzophenone derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
    Ma XD, Zhang X, Dai HF, Yang SQ, Yang LM, Gu SX, Zheng YT, He QQ, Chen FE.
    Bioorg Med Chem; 2011 Aug 01; 19(15):4601-7. PubMed ID: 21719299
    [Abstract] [Full Text] [Related]

  • 15. Synthesis, HIV-RT inhibitory activity and SAR of 1-benzyl-1H-1,2,3-triazole derivatives of carbohydrates.
    da Silva Fde C, de Souza MC, Frugulhetti II, Castro HC, Souza SL, de Souza TM, Rodrigues DQ, Souza AM, Abreu PA, Passamani F, Rodrigues CR, Ferreira VF.
    Eur J Med Chem; 2009 Jan 01; 44(1):373-83. PubMed ID: 18486994
    [Abstract] [Full Text] [Related]

  • 16. Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents.
    Monforte AM, Logoteta P, Ferro S, De Luca L, Iraci N, Maga G, Clercq ED, Pannecouque C, Chimirri A.
    Bioorg Med Chem; 2009 Aug 15; 17(16):5962-7. PubMed ID: 19616956
    [Abstract] [Full Text] [Related]

  • 17. Arylazolylthioacetanilide. Part 8: Design, synthesis and biological evaluation of novel 2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)-N-arylacetamides as potent HIV-1 inhibitors.
    Zhan P, Chen X, Li X, Li D, Tian Y, Chen W, Pannecouque C, De Clercq E, Liu X.
    Eur J Med Chem; 2011 Oct 15; 46(10):5039-45. PubMed ID: 21872971
    [Abstract] [Full Text] [Related]

  • 18. 2-(Aryl)-3-furan-2-ylmethyl-thiazolidin-4-ones as selective HIV-RT inhibitors.
    Rawal RK, Prabhakar YS, Katti SB, De Clercq E.
    Bioorg Med Chem; 2005 Dec 15; 13(24):6771-6. PubMed ID: 16198576
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
    Ji L, Chen FE, De Clercq E, Balzarini J, Pannecouque C.
    J Med Chem; 2007 Apr 19; 50(8):1778-86. PubMed ID: 17381078
    [Abstract] [Full Text] [Related]

  • 20. Revealing interaction mode between HIV-1 reverse transcriptase and diaryltriazine analog inhibitor.
    Li Z, Han J, Chen HF.
    Chem Biol Drug Des; 2008 Nov 19; 72(5):350-9. PubMed ID: 19012571
    [Abstract] [Full Text] [Related]

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