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177 related items for PubMed ID: 1813212

  • 1. Antibody directed enzyme prodrug therapy (ADEPT): a three phase system.
    Sharma SK, Bagshawe KD, Springer CJ, Burke PJ, Rogers GT, Boden JA, Antoniw P, Melton RG, Sherwood RF.
    Dis Markers; 1991; 9(3-4):225-31. PubMed ID: 1813212
    [Abstract] [Full Text] [Related]

  • 2. Enhancement of antibody-directed enzyme prodrug therapy in colorectal xenografts by an antivascular agent.
    Pedley RB, Sharma SK, Boxer GM, Boden R, Stribbling SM, Davies L, Springer CJ, Begent RH.
    Cancer Res; 1999 Aug 15; 59(16):3998-4003. PubMed ID: 10463598
    [Abstract] [Full Text] [Related]

  • 3. Antibody directed enzyme prodrug therapy (ADEPT): clinical report.
    Bagshawe KD, Sharma SK, Springer CJ, Antoniw P, Boden JA, Rogers GT, Burke PJ, Melton RG, Sherwood RF.
    Dis Markers; 1991 Aug 15; 9(3-4):233-8. PubMed ID: 1813213
    [Abstract] [Full Text] [Related]

  • 4. ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts.
    Blakey DC, Burke PJ, Davies DH, Dowell RI, East SJ, Eckersley KP, Fitton JE, McDaid J, Melton RG, Niculescu-Duvaz IA, Pinder PE, Sharma SK, Wright AF, Springer CJ.
    Cancer Res; 1996 Jul 15; 56(14):3287-92. PubMed ID: 8764123
    [Abstract] [Full Text] [Related]

  • 5. Biodistribution of an antibody-enzyme conjugate for antibody-directed enzyme prodrug therapy in nude mice bearing a human colon adenocarcinoma xenograft.
    Stribbling SM, Martin J, Pedley RB, Boden JA, Sharma SK, Springer CJ.
    Cancer Chemother Pharmacol; 1997 Jul 15; 40(4):277-84. PubMed ID: 9225945
    [Abstract] [Full Text] [Related]

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  • 7. Antibody-directed enzyme prodrug therapy: efficacy and mechanism of action in colorectal carcinoma.
    Napier MP, Sharma SK, Springer CJ, Bagshawe KD, Green AJ, Martin J, Stribbling SM, Cushen N, O'Malley D, Begent RH.
    Clin Cancer Res; 2000 Mar 15; 6(3):765-72. PubMed ID: 10741695
    [Abstract] [Full Text] [Related]

  • 8. Antibody-directed enzyme prodrug therapy (ADEPT). A three-phase study in ovarian tumor xenografts.
    Sharma SK, Boden JA, Springer CJ, Burke PJ, Bagshawe KD.
    Cell Biophys; 1994 Mar 15; 24-25():219-28. PubMed ID: 7736526
    [Abstract] [Full Text] [Related]

  • 9. Plasma clearance of an antibody--enzyme conjugate in ADEPT by monoclonal anti-enzyme: its effect on prodrug activation in vivo.
    Rogers GT, Burke PJ, Sharma SK, Koodie R, Boden JA.
    Br J Cancer; 1995 Dec 15; 72(6):1357-63. PubMed ID: 8519645
    [Abstract] [Full Text] [Related]

  • 10. Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbB2 p185.
    Eccles SA, Court WJ, Box GA, Dean CJ, Melton RG, Springer CJ.
    Cancer Res; 1994 Oct 01; 54(19):5171-7. PubMed ID: 7923136
    [Abstract] [Full Text] [Related]

  • 11. Anti-tumour effects of an antibody-carboxypeptidase G2 conjugate in combination with phenol mustard prodrugs.
    Blakey DC, Davies DH, Dowell RI, East SJ, Burke PJ, Sharma SK, Springer CJ, Mauger AB, Melton RG.
    Br J Cancer; 1995 Nov 01; 72(5):1083-8. PubMed ID: 7577451
    [Abstract] [Full Text] [Related]

  • 12. A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug.
    Mayer A, Francis RJ, Sharma SK, Tolner B, Springer CJ, Martin J, Boxer GM, Bell J, Green AJ, Hartley JA, Cruickshank C, Wren J, Chester KA, Begent RH.
    Clin Cancer Res; 2006 Nov 01; 12(21):6509-16. PubMed ID: 17085666
    [Abstract] [Full Text] [Related]

  • 13. Antibody-directed enzyme prodrug therapy (ADEPT) with mustard prodrugs.
    Springer CJ, Niculescu-Duvaz I.
    Anticancer Drug Des; 1995 Jul 01; 10(5):361-72. PubMed ID: 7639927
    [Abstract] [Full Text] [Related]

  • 14. In vitro and in vivo comparison of a randomly coupled antibody fragment-enzyme conjugate with a site-specific conjugate.
    Werlen RC, Offord RE, Blakey DC, East SJ, Melton RG, Rose K.
    Biomed Pept Proteins Nucleic Acids; 1995 Jul 01; 1(5):251-4. PubMed ID: 9575348
    [Abstract] [Full Text] [Related]

  • 15. Ablation of human choriocarcinoma xenografts in nude mice by antibody-directed enzyme prodrug therapy (ADEPT) with three novel compounds.
    Springer CJ, Bagshawe KD, Sharma SK, Searle F, Boden JA, Antoniw P, Burke PJ, Rogers GT, Sherwood RF, Melton RG.
    Eur J Cancer; 1991 Jul 01; 27(11):1361-6. PubMed ID: 1835849
    [Abstract] [Full Text] [Related]

  • 16. Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial.
    Martin J, Stribbling SM, Poon GK, Begent RH, Napier M, Sharma SK, Springer CJ.
    Cancer Chemother Pharmacol; 1997 Jul 01; 40(3):189-201. PubMed ID: 9219501
    [Abstract] [Full Text] [Related]

  • 17. Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material.
    Webley SD, Francis RJ, Pedley RB, Sharma SK, Begent RH, Hartley JA, Hochhauser D.
    Br J Cancer; 2001 Jun 15; 84(12):1671-6. PubMed ID: 11401322
    [Abstract] [Full Text] [Related]

  • 18. Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.
    Friedlos F, Lehouritis P, Ogilvie L, Hedley D, Davies L, Bermudes D, King I, Martin J, Marais R, Springer CJ.
    Clin Cancer Res; 2008 Jul 01; 14(13):4259-66. PubMed ID: 18594008
    [Abstract] [Full Text] [Related]

  • 19. Novel inhibitors of carboxypeptidase G2 (CPG2): potential use in antibody-directed enzyme prodrug therapy.
    Khan TH, Eno-Amooquaye EA, Searle F, Browne PJ, Osborn HM, Burke PJ.
    J Med Chem; 1999 Mar 25; 42(6):951-6. PubMed ID: 10090777
    [Abstract] [Full Text] [Related]

  • 20. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.
    Schepelmann S, Ogilvie LM, Hedley D, Friedlos F, Martin J, Scanlon I, Chen P, Marais R, Springer CJ.
    Cancer Res; 2007 May 15; 67(10):4949-55. PubMed ID: 17510425
    [Abstract] [Full Text] [Related]

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