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189 related items for PubMed ID: 18162716

  • 1. ERK-1/-2 and p38 kinase oppositely regulate 15-deoxy-delta(12,14)-prostaglandinJ(2)-Induced PPAR-gamma activation that mediates dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes.
    Yoon EK, Lee WK, Lee JH, Yu SM, Hwang SG, Kim SJ.
    J Korean Med Sci; 2007 Dec; 22(6):1015-21. PubMed ID: 18162716
    [Abstract] [Full Text] [Related]

  • 2. 15-deoxy-Delta 12,14-ProstaglandinJ2 regulates dedifferentiation through peroxisome proliferator-activated receptor-gamma-dependent pathway but not COX-2 expression in articular chondrocytes.
    Lee JH, Yu SM, Yoon EK, Lee WK, Jung JC, Kim SJ.
    J Korean Med Sci; 2007 Oct; 22(5):891-7. PubMed ID: 17982241
    [Abstract] [Full Text] [Related]

  • 3. Nanomolar and micromolar effects of 15-deoxy-delta 12,14-prostaglandin J2 on amnion-derived WISH epithelial cells: differential roles of peroxisome proliferator-activated receptors gamma and delta and nuclear factor kappa B.
    Berry EB, Keelan JA, Helliwell RJ, Gilmour RS, Mitchell MD.
    Mol Pharmacol; 2005 Jul; 68(1):169-78. PubMed ID: 15821150
    [Abstract] [Full Text] [Related]

  • 4. Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism.
    Grau R, Iñiguez MA, Fresno M.
    Cancer Res; 2004 Aug 01; 64(15):5162-71. PubMed ID: 15289320
    [Abstract] [Full Text] [Related]

  • 5. Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages.
    Yano M, Matsumura T, Senokuchi T, Ishii N, Murata Y, Taketa K, Motoshima H, Taguchi T, Sonoda K, Kukidome D, Takuwa Y, Kawada T, Brownlee M, Nishikawa T, Araki E.
    Circ Res; 2007 May 25; 100(10):1442-51. PubMed ID: 17463321
    [Abstract] [Full Text] [Related]

  • 6. Non-steroidal anti-inflammatory drugs inhibit nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes independent of cyclooxygenase activity.
    Yoon JB, Kim SJ, Hwang SG, Chang S, Kang SS, Chun JS.
    J Biol Chem; 2003 Apr 25; 278(17):15319-25. PubMed ID: 12588866
    [Abstract] [Full Text] [Related]

  • 7. Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytes.
    Huh YH, Kim SH, Kim SJ, Chun JS.
    J Biol Chem; 2003 Mar 14; 278(11):9691-7. PubMed ID: 12493746
    [Abstract] [Full Text] [Related]

  • 8. 15-Deoxy-delta12,14-prostaglandin-J(2) up-regulates cyclooxygenase-2 but inhibits prostaglandin-E(2) production through a thiol antioxidant-sensitive mechanism.
    Reyes-Martin P, Ramirez-Rubio S, Parra-Cid T, Bienes-Martínez R, Lucio-Cazana J.
    Pharmacol Res; 2008 May 14; 57(5):344-50. PubMed ID: 18456507
    [Abstract] [Full Text] [Related]

  • 9. Activation of p38 mitogen-activated protein kinase and activator protein-1 during the promotion of neurite extension of PC-12 cells by 15-deoxy-delta12,14-prostaglandin J2.
    Jung KM, Park KS, Oh JH, Jung SY, Yang KH, Song YS, Son DJ, Park YH, Yun YP, Lee MK, Oh KW, Hong JT.
    Mol Pharmacol; 2003 Mar 14; 63(3):607-16. PubMed ID: 12606768
    [Abstract] [Full Text] [Related]

  • 10. 15-Deoxy-Δ12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species.
    Kitz K, Windischhofer W, Leis HJ, Huber E, Kollroser M, Malle E.
    Free Radic Biol Med; 2011 Apr 01; 50(7):854-65. PubMed ID: 21236332
    [Abstract] [Full Text] [Related]

  • 11. PEP-1-SIRT2 causes dedifferentiation and COX-2 expression via the MAPK pathways in rabbit articular chondrocytes.
    Eo SH, Kim DW, Choi SY, Kim HA, Kim SJ.
    Exp Cell Res; 2015 Dec 10; 339(2):351-9. PubMed ID: 26358233
    [Abstract] [Full Text] [Related]

  • 12. Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma).
    Patel KM, Wright KL, Whittaker P, Chakravarty P, Watson ML, Ward SG.
    Cell Signal; 2005 Sep 10; 17(9):1098-110. PubMed ID: 15993751
    [Abstract] [Full Text] [Related]

  • 13. ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status.
    Kim SJ, Ju JW, Oh CD, Yoon YM, Song WK, Kim JH, Yoo YJ, Bang OS, Kang SS, Chun JS.
    J Biol Chem; 2002 Jan 11; 277(2):1332-9. PubMed ID: 11689560
    [Abstract] [Full Text] [Related]

  • 14. Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism.
    Farrajota K, Cheng S, Martel-Pelletier J, Afif H, Pelletier JP, Li X, Ranger P, Fahmi H.
    Arthritis Rheum; 2005 Jan 11; 52(1):94-104. PubMed ID: 15641079
    [Abstract] [Full Text] [Related]

  • 15. 15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-1beta-induced IKK enzymatic activity and IkappaBalpha degradation in rat chondrocytes through a PPARgamma-independent pathway.
    Boyault S, Bianchi A, Moulin D, Morin S, Francois M, Netter P, Terlain B, Bordji K.
    FEBS Lett; 2004 Aug 13; 572(1-3):33-40. PubMed ID: 15304320
    [Abstract] [Full Text] [Related]

  • 16. 15d-PGJ(2) is acting as a 'dual agent' on the regulation of COX-2 expression in human osteoarthritic chondrocytes.
    Fahmi H, Pelletier JP, Mineau F, Martel-Pelletier J.
    Osteoarthritis Cartilage; 2002 Nov 13; 10(11):845-8. PubMed ID: 12435328
    [Abstract] [Full Text] [Related]

  • 17. Cytokine-induced apoptosis inhibitor-1 causes dedifferentiation of rabbit articular chondrocytes via the ERK-1/2 and p38 kinase pathways.
    Yu SM, Yeo HJ, Choi SY, Kim SJ.
    Int J Biochem Cell Biol; 2016 Nov 13; 80():10-18. PubMed ID: 27644154
    [Abstract] [Full Text] [Related]

  • 18. 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal transduction pathway in HT-29 colon cancer cells.
    Chen ZY, Tseng CC.
    Mol Pharmacol; 2005 Nov 13; 68(5):1203-13. PubMed ID: 16077033
    [Abstract] [Full Text] [Related]

  • 19. Actin cytoskeletal architecture regulates nitric oxide-induced apoptosis, dedifferentiation, and cyclooxygenase-2 expression in articular chondrocytes via mitogen-activated protein kinase and protein kinase C pathways.
    Kim SJ, Hwang SG, Kim IC, Chun JS.
    J Biol Chem; 2003 Oct 24; 278(43):42448-56. PubMed ID: 12907684
    [Abstract] [Full Text] [Related]

  • 20. 15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues.
    Lappas M, Permezel M, Rice GE.
    Placenta; 2006 Oct 24; 27(11-12):1060-72. PubMed ID: 16434095
    [Abstract] [Full Text] [Related]

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