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Journal Abstract Search

491 related items for PubMed ID: 18175003

  • 1. Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites.
    Lee K, Ryu JS, Jin Y, Kim W, Kaur N, Chung SJ, Jeon YJ, Park JT, Bang JS, Lee HS, Kim TY, Lee JJ, Hong YS.
    Org Biomol Chem; 2008 Jan 21; 6(2):340-8. PubMed ID: 18175003
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
    Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J, Sydor JR, Tibbitts TT, Tong JK, Adams J, Palombella VJ.
    J Med Chem; 2006 Jul 27; 49(15):4606-15. PubMed ID: 16854066
    [Abstract] [Full Text] [Related]

  • 3. Potent cytotoxic C-11 modified geldanamycin analogues.
    Tian ZQ, Wang Z, MacMillan KS, Zhou Y, Carreras CW, Mueller T, Myles DC, Liu Y.
    J Med Chem; 2009 May 28; 52(10):3265-73. PubMed ID: 19405528
    [Abstract] [Full Text] [Related]

  • 4. Molecular characterization of macbecin as an Hsp90 inhibitor.
    Martin CJ, Gaisser S, Challis IR, Carletti I, Wilkinson B, Gregory M, Prodromou C, Roe SM, Pearl LH, Boyd SM, Zhang MQ.
    J Med Chem; 2008 May 08; 51(9):2853-7. PubMed ID: 18357975
    [Abstract] [Full Text] [Related]

  • 5. Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors.
    Li Z, Jia L, Wang J, Wu X, Hao H, Xu H, Wu Y, Shi G, Lu C, Shen Y.
    Eur J Med Chem; 2014 Oct 06; 85():359-70. PubMed ID: 25105924
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.
    Le Brazidec JY, Kamal A, Busch D, Thao L, Zhang L, Timony G, Grecko R, Trent K, Lough R, Salazar T, Khan S, Burrows F, Boehm MF.
    J Med Chem; 2004 Jul 15; 47(15):3865-73. PubMed ID: 15239664
    [Abstract] [Full Text] [Related]

  • 7. Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90.
    Sydor JR, Normant E, Pien CS, Porter JR, Ge J, Grenier L, Pak RH, Ali JA, Dembski MS, Hudak J, Patterson J, Penders C, Pink M, Read MA, Sang J, Woodward C, Zhang Y, Grayzel DS, Wright J, Barrett JA, Palombella VJ, Adams J, Tong JK.
    Proc Natl Acad Sci U S A; 2006 Nov 14; 103(46):17408-13. PubMed ID: 17090671
    [Abstract] [Full Text] [Related]

  • 8. Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin.
    McErlean CS, Proisy N, Davis CJ, Boland NA, Sharp SY, Boxall K, Slawin AM, Workman P, Moody CJ.
    Org Biomol Chem; 2007 Feb 07; 5(3):531-46. PubMed ID: 17252137
    [Abstract] [Full Text] [Related]

  • 9. Discovery of novel 17-phenylethylaminegeldanamycin derivatives as potent Hsp90 inhibitors.
    Li Z, Jia L, Wang J, Wu X, Shi G, Lu C, Shen Y.
    Chem Biol Drug Des; 2015 Feb 07; 85(2):181-8. PubMed ID: 24903735
    [Abstract] [Full Text] [Related]

  • 10. Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors.
    Li Z, Jia L, Wang J, Wu X, Hao H, Wu Y, Xu H, Wang Z, Shi G, Lu C, Shen Y.
    Eur J Med Chem; 2014 Nov 24; 87():346-63. PubMed ID: 25277067
    [Abstract] [Full Text] [Related]

  • 11. Heat shock protein 90: inhibitors in clinical trials.
    Biamonte MA, Van de Water R, Arndt JW, Scannevin RH, Perret D, Lee WC.
    J Med Chem; 2010 Jan 14; 53(1):3-17. PubMed ID: 20055425
    [No Abstract] [Full Text] [Related]

  • 12. New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus.
    Wu CZ, Moon AN, Jang JH, Lee D, Kang SY, Park JT, Ahn JS, Hwang BY, Kim YH, Lee HS, Hong YS.
    J Antibiot (Tokyo); 2011 Jun 14; 64(6):461-3. PubMed ID: 21448187
    [No Abstract] [Full Text] [Related]

  • 13. Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.
    Zapf CW, Bloom JD, McBean JL, Dushin RG, Nittoli T, Otteng M, Ingalls C, Golas JM, Liu H, Lucas J, Boschelli F, Hu Y, Vogan E, Levin JI.
    Bioorg Med Chem Lett; 2011 Jun 01; 21(11):3411-6. PubMed ID: 21515049
    [Abstract] [Full Text] [Related]

  • 14. Conformational significance of EH21A1-A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity.
    Onodera H, Kaneko M, Takahashi Y, Uochi Y, Funahashi J, Nakashima T, Soga S, Suzuki M, Ikeda S, Yamashita Y, Rahayu ES, Kanda Y, Ichimura M.
    Bioorg Med Chem Lett; 2008 Mar 01; 18(5):1588-91. PubMed ID: 18243703
    [Abstract] [Full Text] [Related]

  • 15. Rational biosynthetic engineering for optimization of geldanamycin analogues.
    Kim W, Lee D, Hong SS, Na Z, Shin JC, Roh SH, Wu CZ, Choi O, Lee K, Shen YM, Paik SG, Lee JJ, Hong YS.
    Chembiochem; 2009 May 04; 10(7):1243-51. PubMed ID: 19308924
    [Abstract] [Full Text] [Related]

  • 16. The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library.
    Eichner S, Knobloch T, Floss HG, Fohrer J, Harmrolfs K, Hermane J, Schulz A, Sasse F, Spiteller P, Taft F, Kirschning A.
    Angew Chem Int Ed Engl; 2012 Jan 16; 51(3):752-7. PubMed ID: 22135226
    [No Abstract] [Full Text] [Related]

  • 17. Expression of epidermal growth factor receptor or ErbB3 facilitates geldanamycin-induced down-regulation of ErbB2.
    Pedersen NM, Breen K, Rødland MS, Haslekås C, Stang E, Madshus IH.
    Mol Cancer Res; 2009 Feb 16; 7(2):275-84. PubMed ID: 19208749
    [Abstract] [Full Text] [Related]

  • 18. Engineered biosynthesis of geldanamycin analogs for Hsp90 inhibition.
    Patel K, Piagentini M, Rascher A, Tian ZQ, Buchanan GO, Regentin R, Hu Z, Hutchinson CR, McDaniel R.
    Chem Biol; 2004 Dec 16; 11(12):1625-33. PubMed ID: 15610846
    [Abstract] [Full Text] [Related]

  • 19. Rational design and synthesis of ansa-adenosines as potential antitumor agents.
    Muranaka K, Ichikawa S, Matsuda A.
    Nucleic Acids Symp Ser (Oxf); 2009 Dec 16; (53):5-6. PubMed ID: 19749232
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and biological evaluation of geldanamycin analogs against human cancer cells.
    Li YP, Chen JJ, Shen JJ, Cui J, Wu LZ, Wang Z, Li ZR.
    Cancer Chemother Pharmacol; 2015 Apr 16; 75(4):773-82. PubMed ID: 25681003
    [Abstract] [Full Text] [Related]

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