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Journal Abstract Search

101 related items for PubMed ID: 18178086

  • 1. Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents.
    Beck HP, Kohn T, Rubenstein S, Hedberg C, Schwandner R, Hasslinger K, Dai K, Li C, Liang L, Wesche H, Frank B, An S, Wickramasinghe D, Jaen J, Medina J, Hungate R, Shen W.
    Bioorg Med Chem Lett; 2008 Feb 01; 18(3):1037-41. PubMed ID: 18178086
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  • 3. Synthesis and structure-activity relationship studies of cytotoxic anhydrovinblastine amide derivatives.
    Shao Y, Zhang HK, Ding H, Quan HT, Lou LG, Hu LH.
    J Nat Prod; 2009 Jun 01; 72(6):1170-7. PubMed ID: 19499938
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  • 4. Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands.
    Durgam GG, Tsukahara R, Makarova N, Walker MD, Fujiwara Y, Pigg KR, Baker DL, Sardar VM, Parrill AL, Tigyi G, Miller DD.
    Bioorg Med Chem Lett; 2006 Feb 01; 16(3):633-40. PubMed ID: 16263282
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  • 5. 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.
    Spicer JA, Rewcastle GW, Kaufman MD, Black SL, Plummer MS, Denny WA, Quin J, Shahripour AB, Barrett SD, Whitehead CE, Milbank JB, Ohren JF, Gowan RC, Omer C, Camp HS, Esmaeil N, Moore K, Sebolt-Leopold JS, Pryzbranowski S, Merriman RL, Ortwine DF, Warmus JS, Flamme CM, Pavlovsky AG, Tecle H.
    J Med Chem; 2007 Oct 18; 50(21):5090-102. PubMed ID: 17880056
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  • 6. Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist.
    Heasley BH, Jarosz R, Lynch KR, Macdonald TL.
    Bioorg Med Chem Lett; 2004 Jun 07; 14(11):2735-40. PubMed ID: 15125924
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  • 7. Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
    Durgam GG, Virag T, Walker MD, Tsukahara R, Yasuda S, Liliom K, van Meeteren LA, Moolenaar WH, Wilke N, Siess W, Tigyi G, Miller DD.
    J Med Chem; 2005 Jul 28; 48(15):4919-30. PubMed ID: 16033271
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  • 8. A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a nonhydrolyzable LPA3 receptor-selective antagonist.
    Heasley BH, Jarosz R, Carter KM, Van SJ, Lynch KR, Macdonald TL.
    Bioorg Med Chem Lett; 2004 Aug 02; 14(15):4069-74. PubMed ID: 15225728
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  • 9. Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone.
    Kung PP, Funk L, Meng J, Collins M, Zhou JZ, Johnson MC, Ekker A, Wang J, Mehta P, Yin MJ, Rodgers C, Davies JF, Bayman E, Smeal T, Maegley KA, Gehring MR.
    Bioorg Med Chem Lett; 2008 Dec 01; 18(23):6273-8. PubMed ID: 18929486
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  • 10. Activation of the RAF/mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway mediates apoptosis induced by chelerythrine in osteosarcoma.
    Yang R, Piperdi S, Gorlick R.
    Clin Cancer Res; 2008 Oct 15; 14(20):6396-404. PubMed ID: 18927278
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  • 11. Phosphonothioate and fluoromethylene phosphonate analogues of cyclic phosphatidic acid: Novel antagonists of lysophosphatidic acid receptors.
    Xu Y, Jiang G, Tsukahara R, Fujiwara Y, Tigyi G, Prestwich GD.
    J Med Chem; 2006 Aug 24; 49(17):5309-15. PubMed ID: 16913720
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  • 12. Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model.
    Bilodeau MT, Balitza AE, Hoffman JM, Manley PJ, Barnett SF, Defeo-Jones D, Haskell K, Jones RE, Leander K, Robinson RG, Smith AM, Huber HE, Hartman GD.
    Bioorg Med Chem Lett; 2008 Jun 01; 18(11):3178-82. PubMed ID: 18479914
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  • 13. Betagamma subunits of G(i/o) suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced.
    Obara Y, Okano Y, Ono S, Yamauchi A, Hoshino T, Kurose H, Nakahata N.
    Cell Signal; 2008 Jul 01; 20(7):1275-83. PubMed ID: 18407464
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  • 17. Discovery of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers. 2. Identification of more aqueous soluble analogs as potential anticancer agents.
    Kemnitzer W, Kuemmerle J, Zhang HZ, Kasibhatla S, Tseng B, Drewe J, Cai SX.
    Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4410-5. PubMed ID: 19500976
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  • 18. Magnolol elicits activation of the extracellular signal-regulated kinase pathway by inducing p27KIP1-mediated G2/M-phase cell cycle arrest in human urinary bladder cancer 5637 cells.
    Lee SJ, Cho YH, Park K, Kim EJ, Jung KH, Park SS, Kim WJ, Moon SK.
    Biochem Pharmacol; 2008 Jun 15; 75(12):2289-300. PubMed ID: 18468578
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  • 19. Design of anticancer lysophosphatidic acid agonists and antagonists.
    Parrill AL.
    Future Med Chem; 2014 May 15; 6(8):871-83. PubMed ID: 24962280
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  • 20. Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.
    Harmange JC, Weiss MM, Germain J, Polverino AJ, Borg G, Bready J, Chen D, Choquette D, Coxon A, DeMelfi T, DiPietro L, Doerr N, Estrada J, Flynn J, Graceffa RF, Harriman SP, Kaufman S, La DS, Long A, Martin MW, Neervannan S, Patel VF, Potashman M, Regal K, Roveto PM, Schrag ML, Starnes C, Tasker A, Teffera Y, Wang L, White RD, Whittington DA, Zanon R.
    J Med Chem; 2008 Mar 27; 51(6):1649-67. PubMed ID: 18324761
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