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Journal Abstract Search

226 related items for PubMed ID: 18178668

  • 1. BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3h-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase.
    Tiso M, Strub A, Hesslinger C, Kenney CT, Boer R, Stuehr DJ.
    Mol Pharmacol; 2008 Apr; 73(4):1244-53. PubMed ID: 18178668
    [Abstract] [Full Text] [Related]

  • 2. The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase.
    Strub A, Ulrich WR, Hesslinger C, Eltze M, Fuchss T, Strassner J, Strand S, Lehner MD, Boer R.
    Mol Pharmacol; 2006 Jan; 69(1):328-37. PubMed ID: 16223957
    [Abstract] [Full Text] [Related]

  • 3. In vivo characterization of the novel imidazopyridine BYK191023 [2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine], a potent and highly selective inhibitor of inducible nitric-oxide synthase.
    Lehner MD, Marx D, Boer R, Strub A, Hesslinger C, Eltze M, Ulrich WR, Schwoebel F, Schermuly RT, Barsig J.
    J Pharmacol Exp Ther; 2006 Apr; 317(1):181-7. PubMed ID: 16368897
    [Abstract] [Full Text] [Related]

  • 4. Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification.
    Zhu Y, Nikolic D, Van Breemen RB, Silverman RB.
    J Am Chem Soc; 2005 Jan 26; 127(3):858-68. PubMed ID: 15656623
    [Abstract] [Full Text] [Related]

  • 5. A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms.
    Wang ZQ, Wei CC, Santolini J, Panda K, Wang Q, Stuehr DJ.
    Biochemistry; 2005 Mar 29; 44(12):4676-90. PubMed ID: 15779894
    [Abstract] [Full Text] [Related]

  • 6. Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase.
    Presta A, Siddhanta U, Wu C, Sennequier N, Huang L, Abu-Soud HM, Erzurum S, Stuehr DJ.
    Biochemistry; 1998 Jan 06; 37(1):298-310. PubMed ID: 9425051
    [Abstract] [Full Text] [Related]

  • 7. Active-site structure analysis of recombinant human inducible nitric oxide synthase using imidazole.
    Chabin RM, McCauley E, Calaycay JR, Kelly TM, MacNaul KL, Wolfe GC, Hutchinson NI, Madhusudanaraju S, Schmidt JA, Kozarich JW, Wong KK.
    Biochemistry; 1996 Jul 23; 35(29):9567-75. PubMed ID: 8755738
    [Abstract] [Full Text] [Related]

  • 8. Mechanism of inducible nitric oxide synthase inactivation by aminoguanidine and L-N6-(1-iminoethyl)lysine.
    Bryk R, Wolff DJ.
    Biochemistry; 1998 Apr 07; 37(14):4844-52. PubMed ID: 9538001
    [Abstract] [Full Text] [Related]

  • 9. Analysis of substrate-induced electronic, catalytic, and structural changes in inducible NO synthase.
    Sennequier N, Stuehr DJ.
    Biochemistry; 1996 May 07; 35(18):5883-92. PubMed ID: 8639550
    [Abstract] [Full Text] [Related]

  • 10. KLYP956 is a non-imidazole-based orally active inhibitor of nitric-oxide synthase dimerization.
    Symons KT, Massari ME, Nguyen PM, Lee TT, Roppe J, Bonnefous C, Payne JE, Smith ND, Noble SA, Sablad M, Rozenkrants N, Zhang Y, Rao TS, Shiau AK, Hassig CA.
    Mol Pharmacol; 2009 Jul 07; 76(1):153-62. PubMed ID: 19364813
    [Abstract] [Full Text] [Related]

  • 11. Inhibition of nitric oxide synthase isoforms by porphyrins.
    Wolff DJ, Naddelman RA, Lubeskie A, Saks DA.
    Arch Biochem Biophys; 1996 Sep 01; 333(1):27-34. PubMed ID: 8806750
    [Abstract] [Full Text] [Related]

  • 12. Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.
    Grädler U, Fuchss T, Ulrich WR, Boer R, Strub A, Hesslinger C, Anézo C, Diederichs K, Zaliani A.
    Bioorg Med Chem Lett; 2011 Jul 15; 21(14):4228-32. PubMed ID: 21684157
    [Abstract] [Full Text] [Related]

  • 13. Cellular and enzymatic studies of N(omega)-propyl-l-arginine and S-ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea as reversible, slowly dissociating inhibitors selective for the neuronal nitric oxide synthase isoform.
    Cooper GR, Mialkowski K, Wolff DJ.
    Arch Biochem Biophys; 2000 Mar 01; 375(1):183-94. PubMed ID: 10683266
    [Abstract] [Full Text] [Related]

  • 14. Mechanism of inducible nitric-oxide synthase dimerization inhibition by novel pyrimidine imidazoles.
    Nagpal L, Haque MM, Saha A, Mukherjee N, Ghosh A, Ranu BC, Stuehr DJ, Panda K.
    J Biol Chem; 2013 Jul 05; 288(27):19685-97. PubMed ID: 23696643
    [Abstract] [Full Text] [Related]

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  • 16. Oxidation of NG-hydroxy-L-arginine by nitric oxide synthase: evidence for the involvement of the heme in catalysis.
    Pufahl RA, Marletta MA.
    Biochem Biophys Res Commun; 1993 Jun 30; 193(3):963-70. PubMed ID: 7686757
    [Abstract] [Full Text] [Related]

  • 17. How does a valine residue that modulates heme-NO binding kinetics in inducible NO synthase regulate enzyme catalysis?
    Wang ZQ, Wei CC, Stuehr DJ.
    J Inorg Biochem; 2010 Mar 30; 104(3):349-56. PubMed ID: 20006999
    [Abstract] [Full Text] [Related]

  • 18. PPA250 [3-(2,4-difluorophenyl)-6-[2-[4-(1H-imidazol-1-ylmethyl) phenoxy]ethoxy]-2-phenylpyridine], a novel orally effective inhibitor of the dimerization of inducible nitric-oxide synthase, exhibits an anti-inflammatory effect in animal models of chronic arthritis.
    Ohtsuka M, Konno F, Honda H, Oikawa T, Ishikawa M, Iwase N, Isomae K, Ishii F, Hemmi H, Sato S.
    J Pharmacol Exp Ther; 2002 Oct 30; 303(1):52-7. PubMed ID: 12235232
    [Abstract] [Full Text] [Related]

  • 19. Structural requirements for human inducible nitric oxide synthase substrates and substrate analogue inhibitors.
    Grant SK, Green BG, Stiffey-Wilusz J, Durette PL, Shah SK, Kozarich JW.
    Biochemistry; 1998 Mar 24; 37(12):4174-80. PubMed ID: 9521739
    [Abstract] [Full Text] [Related]

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