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Journal Abstract Search


569 related items for PubMed ID: 18187583

  • 1. Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells.
    Giovannetti E, Lemos C, Tekle C, Smid K, Nannizzi S, Rodriguez JA, Ricciardi S, Danesi R, Giaccone G, Peters GJ.
    Mol Pharmacol; 2008 Apr; 73(4):1290-300. PubMed ID: 18187583
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  • 2. Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells.
    Tekle C, Giovannetti E, Sigmond J, Graff JR, Smid K, Peters GJ.
    Br J Cancer; 2008 Sep 02; 99(5):750-9. PubMed ID: 18728666
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  • 3. Combined gefitinib and pemetrexed overcome the acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer.
    Wu M, Yuan Y, Pan YY, Zhang Y.
    Mol Med Rep; 2014 Aug 02; 10(2):931-8. PubMed ID: 24840891
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  • 5. Molecular mechanisms and modulation of key pathways underlying the synergistic interaction of sorafenib with erlotinib in non-small-cell-lung cancer (NSCLC) cells.
    Giovannetti E, Labots M, Dekker H, Galvani E, Lind JS, Sciarrillo R, Honeywell R, Smit EF, Verheul HM, Peters GJ.
    Curr Pharm Des; 2013 Aug 02; 19(5):927-39. PubMed ID: 22973961
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  • 6. Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non-small cell lung cancer cells.
    Li T, Ling YH, Goldman ID, Perez-Soler R.
    Clin Cancer Res; 2007 Jun 01; 13(11):3413-22. PubMed ID: 17545550
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  • 9. Effects of pemetrexed, gefitinib, and their combination on human colorectal cancer cells.
    Zhang G, Xie X, Liu T, Yang J, Jiao S.
    Cancer Chemother Pharmacol; 2013 Oct 01; 72(4):767-75. PubMed ID: 23959460
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  • 12. Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin.
    Giovannetti E, Zucali PA, Assaraf YG, Leon LG, Smid K, Alecci C, Giancola F, Destro A, Gianoncelli L, Lorenzi E, Roncalli M, Santoro A, Peters GJ.
    Br J Cancer; 2011 Nov 08; 105(10):1542-53. PubMed ID: 21970874
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  • 14. Antitumor activity of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in non-small cell lung cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels.
    Helfrich BA, Raben D, Varella-Garcia M, Gustafson D, Chan DC, Bemis L, Coldren C, Barón A, Zeng C, Franklin WA, Hirsch FR, Gazdar A, Minna J, Bunn PA.
    Clin Cancer Res; 2006 Dec 01; 12(23):7117-25. PubMed ID: 17145836
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  • 15. Roles of MKK1/2-ERK1/2 and phosphoinositide 3-kinase-AKT signaling pathways in erlotinib-induced Rad51 suppression and cytotoxicity in human non-small cell lung cancer cells.
    Ko JC, Ciou SC, Jhan JY, Cheng CM, Su YJ, Chuang SM, Lin ST, Chang CC, Lin YW.
    Mol Cancer Res; 2009 Aug 01; 7(8):1378-89. PubMed ID: 19671683
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  • 16. Establishment of pemetrexed-resistant non-small cell lung cancer cell lines.
    Zhang D, Ochi N, Takigawa N, Tanimoto Y, Chen Y, Ichihara E, Hotta K, Tabata M, Tanimoto M, Kiura K.
    Cancer Lett; 2011 Oct 28; 309(2):228-35. PubMed ID: 21742432
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  • 19. Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.
    Nannizzi S, Veal GJ, Giovannetti E, Mey V, Ricciardi S, Ottley CJ, Del Tacca M, Danesi R.
    Cancer Chemother Pharmacol; 2010 Aug 28; 66(3):547-58. PubMed ID: 20020129
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  • 20. Combining onartuzumab with erlotinib inhibits growth of non-small cell lung cancer with activating EGFR mutations and HGF overexpression.
    Sano Y, Hashimoto E, Nakatani N, Abe M, Satoh Y, Sakata K, Fujii T, Fujimoto-Ouchi K, Sugimoto M, Nagahashi S, Aoki M, Motegi H, Sasaki E, Yatabe Y.
    Mol Cancer Ther; 2015 Feb 28; 14(2):533-41. PubMed ID: 25522765
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